{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T03:47:18Z","timestamp":1791604038912,"version":"4.3.4"},"reference-count":54,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"182","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sci. Signal."],"published-print":{"date-parts":[[2011,7,19]]},"abstract":"<jats:p>Deacetylation of Akt and its activating kinase PDK1 promotes cell growth in physiological and pathological settings.<\/jats:p>","DOI":"10.1126\/scisignal.2001465","type":"journal-article","created":{"date-parts":[[2011,7,20]],"date-time":"2011-07-20T00:24:15Z","timestamp":1311121455000},"source":"Crossref","is-referenced-by-count":308,"title":["The Deacetylase SIRT1 Promotes Membrane Localization and Activation of Akt and PDK1 During Tumorigenesis and Cardiac Hypertrophy"],"prefix":"10.1126","volume":"4","author":[{"given":"Nagalingam R.","family":"Sundaresan","sequence":"first","affiliation":[{"name":"Department of Surgery, Committee on Cellular and Molecular Physiology, University of Chicago, 5841 South Maryland Avenue, Chicago, IL 60637, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vinodkumar B.","family":"Pillai","sequence":"additional","affiliation":[{"name":"Department of Surgery, Committee on Cellular and Molecular Physiology, University of Chicago, 5841 South Maryland Avenue, Chicago, IL 60637, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Don","family":"Wolfgeher","sequence":"additional","affiliation":[{"name":"Department of Molecular Genetics and Cell Biology, University of Chicago, Chicago, IL 60637, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sadhana","family":"Samant","sequence":"additional","affiliation":[{"name":"Department of Surgery, Committee on Cellular and Molecular Physiology, University of Chicago, 5841 South Maryland Avenue, Chicago, IL 60637, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prabhakaran","family":"Vasudevan","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Committee on Developmental Biology, University of Chicago, Chicago, IL 60637, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vishwas","family":"Parekh","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Committee on Developmental Biology, University of Chicago, Chicago, IL 60637, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hariharasundaram","family":"Raghuraman","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, University of Chicago, Chicago, IL 60637, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John M.","family":"Cunningham","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Committee on Developmental Biology, University of Chicago, Chicago, IL 60637, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madhu","family":"Gupta","sequence":"additional","affiliation":[{"name":"Department of Physiology and Biophysics, University of Illinois, Chicago, IL 60607, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahesh P.","family":"Gupta","sequence":"additional","affiliation":[{"name":"Department of Surgery, Committee on Cellular and Molecular Physiology, University of Chicago, 5841 South Maryland Avenue, Chicago, IL 60637, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81883-8"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2007.06.009"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-9822(06)00122-9"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.271.36.21920"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1106148"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.biophys.27.1.503"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1175371"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature08197"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrm1616"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20070140"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M609554200"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature06261"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-9822(02)00972-7"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M501250200"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(04)00126-6"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.279.5351.710"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.277.5325.567"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature05933"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1175065"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-9822(98)70274-X"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.172376399"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M204572200"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.615138"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellsig.2010.02.008"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.108.193102"},{"key":"e_1_3_2_27_2","first-page":"104","article-title":"IGF-I and longevity","volume":"62","author":"Janssen J. A. M. J. L.","year":"2004","unstructured":"Janssen J. A. M. J. L., Lamberts S. W. J., IGF-I and longevity. Horm. Res. 62, 104\u2013109 (2004).","journal-title":"Horm. Res."},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.emboj.7600045"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrd2060"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2008.05.004"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2008.06.004"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.e07-09-0965"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2005.06.007"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.e05-01-0033"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1094637"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.211430998"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.5.147"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0002020"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrd1902"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000267723.65696.4a"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1101\/gad.435107"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.105.595231"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M200347200"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1139\/Y08-099"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2009.02.006"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.109.215483"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2008.08.014"},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.01339.2007"},{"key":"e_1_3_2_49_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI42933"},{"key":"e_1_3_2_50_2","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.00121-09"},{"key":"e_1_3_2_51_2","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.00426-08"},{"key":"e_1_3_2_52_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M710277200"},{"key":"e_1_3_2_53_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M109.077271"},{"key":"e_1_3_2_54_2","first-page":"2758","article-title":"Sirt3 blocks the cardiac hypertrophic response by augmenting Foxo3a-dependent antioxidant defense mechanisms in mice","volume":"119","author":"Sundaresan N. R.","year":"2009","unstructured":"Sundaresan N. R., Gupta M., Kim G., Rajamohan S. B., Isbatan A., Gupta M. P., Sirt3 blocks the cardiac hypertrophic response by augmenting Foxo3a-dependent antioxidant defense mechanisms in mice. J. Clin. Invest. 119, 2758\u20132771 (2009).","journal-title":"J. Clin. Invest."},{"key":"e_1_3_2_55_2","doi-asserted-by":"publisher","DOI":"10.1042\/bj20031229"}],"container-title":["Science Signaling"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/scisignal.2001465","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,16]],"date-time":"2024-01-16T05:47:56Z","timestamp":1705384076000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/scisignal.2001465"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,7,19]]},"references-count":54,"journal-issue":{"issue":"182","published-print":{"date-parts":[[2011,7,19]]}},"alternative-id":["10.1126\/scisignal.2001465"],"URL":"https:\/\/doi.org\/10.1126\/scisignal.2001465","relation":{},"ISSN":["1945-0877","1937-9145"],"issn-type":[{"value":"1945-0877","type":"print"},{"value":"1937-9145","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,7,19]]}}}