{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T19:33:11Z","timestamp":1791315191076,"version":"4.3.1"},"reference-count":39,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"212","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sci. Signal."],"published-print":{"date-parts":[[2012,2,21]]},"abstract":"<jats:p>Blocking autophagy reduces the extent of lung damage and decreases mortality in mice infected with the H5N1 strain of avian influenza.<\/jats:p>","DOI":"10.1126\/scisignal.2001931","type":"journal-article","created":{"date-parts":[[2012,2,21]],"date-time":"2012-02-21T21:25:38Z","timestamp":1329859538000},"source":"Crossref","is-referenced-by-count":138,"title":["Inhibition of Autophagy Ameliorates Acute Lung Injury Caused by Avian Influenza A H5N1 Infection"],"prefix":"10.1126","volume":"5","author":[{"given":"Yang","family":"Sun","sequence":"first","affiliation":[{"name":"State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Peking Union Medical College, Tsinghua University, Beijing 100005, P. R. China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenggang","family":"Li","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Peking Union Medical College, Tsinghua University, Beijing 100005, P. R. China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuelong","family":"Shu","sequence":"additional","affiliation":[{"name":"State Key Laboratory for Molecular Virology and Genetic Engineering, National Institute for Viral Disease Control and Prevention, China CDC, Changbai 155, Changping District, Beijing 102206, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangwu","family":"Ju","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Peking Union Medical College, Tsinghua University, Beijing 100005, P. R. China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen","family":"Zou","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Peking Union Medical College, Tsinghua University, Beijing 100005, P. R. China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongliang","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Peking Union Medical College, Tsinghua University, Beijing 100005, P. R. China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuan","family":"Rao","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Peking Union Medical College, Tsinghua University, Beijing 100005, P. R. China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Guo","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Peking Union Medical College, Tsinghua University, Beijing 100005, P. R. China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haolin","family":"Liu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Peking Union Medical College, Tsinghua University, Beijing 100005, P. R. China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenlong","family":"Nan","sequence":"additional","affiliation":[{"name":"Genetic Engineering Laboratory, Institute of Military Veterinary, Academy of Military Medical Sciences, Changchun 130062, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Zhao","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Peking Union Medical College, Tsinghua University, Beijing 100005, P. R. China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiwu","family":"Yan","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Peking Union Medical College, Tsinghua University, Beijing 100005, P. R. China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Tang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Peking Union Medical College, Tsinghua University, Beijing 100005, P. R. China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Zhao","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Peking Union Medical College, Tsinghua University, Beijing 100005, P. R. China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Yang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Peking Union Medical College, Tsinghua University, Beijing 100005, P. R. China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kangtai","family":"Liu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Peking Union Medical College, Tsinghua University, Beijing 100005, P. R. China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shunxin","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Peking Union Medical College, Tsinghua University, Beijing 100005, P. R. China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huijun","family":"Lu","sequence":"additional","affiliation":[{"name":"Genetic Engineering Laboratory, Institute of Military Veterinary, Academy of Military Medical Sciences, Changchun 130062, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Li","sequence":"additional","affiliation":[{"name":"Genetic Engineering Laboratory, Institute of Military Veterinary, Academy of Military Medical Sciences, Changchun 130062, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Tan","sequence":"additional","affiliation":[{"name":"Genetic Engineering Laboratory, Institute of Military Veterinary, Academy of Military Medical Sciences, Changchun 130062, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rongbao","family":"Gao","sequence":"additional","affiliation":[{"name":"State Key Laboratory for Molecular Virology and Genetic Engineering, National Institute for Viral Disease Control and Prevention, China CDC, Changbai 155, Changping District, Beijing 102206, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingdong","family":"Song","sequence":"additional","affiliation":[{"name":"State Key Laboratory for Molecular Virology and Genetic Engineering, National Institute for Viral Disease Control and Prevention, China CDC, Changbai 155, Changping District, Beijing 102206, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang","family":"Gao","sequence":"additional","affiliation":[{"name":"MOE Key Laboratory of Model Animal for Disease Study, Model Animal Research Center of Nanjing University, 22 Hankou Road, Nanjing 210093, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinlun","family":"Tian","sequence":"additional","affiliation":[{"name":"Peking Union Medical College Hospital, No.1 Shuaifuyuan, Beijing 100005, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingzhi","family":"Qin","sequence":"additional","affiliation":[{"name":"Peking Union Medical College Hospital, No.1 Shuaifuyuan, Beijing 100005, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai-Feng","family":"Xu","sequence":"additional","affiliation":[{"name":"Peking Union Medical College Hospital, No.1 Shuaifuyuan, Beijing 100005, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dangsheng","family":"Li","sequence":"additional","affiliation":[{"name":"Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ningyi","family":"Jin","sequence":"additional","affiliation":[{"name":"Genetic Engineering Laboratory, Institute of Military Veterinary, Academy of Military Medical Sciences, Changchun 130062, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengyu","family":"Jiang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Peking Union Medical College, Tsinghua University, Beijing 100005, P. R. China."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)60627-3"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1086\/506430"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0002985"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2008.05.019"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11427-009-0059-7"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11427-009-0061-0"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/cr.2009.124"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2008.02.043"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2008.070791"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2004.02.005"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/19.21.5720"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.4161\/auto.2744"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.4161\/auto.4600"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.4161\/auto.5.3.7406"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2009.09.005"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1101\/gad.1599207"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1038\/446745a"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrm1666"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.79.6.1889"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-1033.1997.0240a.x"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M413934200"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0704014104"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.4161\/auto.6555"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biochi.2007.08.014"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2005.08.003"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrm2245"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02082-06"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.21444"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxlet.2007.12.009"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1021\/jf072423r"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1210641"},{"key":"e_1_3_2_33_2","first-page":"187","article-title":"Dexamethasone inhibits paclitaxel-induced cytotoxic activity through retinoblastoma protein dephosphorylation in non-small cell lung cancer cells.","volume":"30","author":"Morita M.","year":"2007","unstructured":"Morita M., Suyama H., Igishi T., Shigeoka Y., Kodani M., Hashimoto K., Takeda K., Sumikawa T., Shimizu E., Dexamethasone inhibits paclitaxel-induced cytotoxic activity through retinoblastoma protein dephosphorylation in non-small cell lung cancer cells. Int. J. Oncol. 30, 187\u2013192 (2007).","journal-title":"Int. J. Oncol."},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-695X.2007.00293.x"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jviromet.2008.08.016"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200511-1751OC"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.3201\/eid1305.060572"},{"key":"e_1_3_2_38_2","first-page":"180","article-title":"The differential expression of the human lung carcinoma cells infected with high pathogenic avian influenza virus A\/Anhui\/1\/2005 (H5N1).","volume":"22","author":"Hu X. F.","year":"2008","unstructured":"Hu X. F., Liu Q. Z., Li C., Dong J., Zhou J. F., Wang M., Shu Y. L., Liu H. T., Liang M. F., Li D. X., The differential expression of the human lung carcinoma cells infected with high pathogenic avian influenza virus A\/Anhui\/1\/2005 (H5N1). Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi 22, 180\u2013182 (2008).","journal-title":"Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1093\/jmcb\/mjp002"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2011.27"}],"container-title":["Science Signaling"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/scisignal.2001931","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,16]],"date-time":"2024-01-16T10:52:44Z","timestamp":1705402364000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/scisignal.2001931"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,2,21]]},"references-count":39,"journal-issue":{"issue":"212","published-print":{"date-parts":[[2012,2,21]]}},"alternative-id":["10.1126\/scisignal.2001931"],"URL":"https:\/\/doi.org\/10.1126\/scisignal.2001931","relation":{},"ISSN":["1945-0877","1937-9145"],"issn-type":[{"value":"1945-0877","type":"print"},{"value":"1937-9145","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,2,21]]}}}