{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T02:58:02Z","timestamp":1789700282615,"version":"4.0.1"},"reference-count":62,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"364","license":[{"start":{"date-parts":[[2016,2,17]],"date-time":"2016-02-17T00:00:00Z","timestamp":1455667200000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/www.sciencemag.org\/about\/science-licenses-journal-article-reuse"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council (NHMRC)","doi-asserted-by":"publisher","award":["626918"],"award-info":[{"award-number":["626918"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000950","name":"Cancer Council of South Australia","doi-asserted-by":"publisher","award":["508105"],"award-info":[{"award-number":["508105"]}],"id":[{"id":"10.13039\/501100000950","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000950","name":"Cancer Council of South Australia","doi-asserted-by":"publisher","award":["399320"],"award-info":[{"award-number":["399320"]}],"id":[{"id":"10.13039\/501100000950","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100003517","name":"Kid';s Cancer Project","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100003517","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"NHMRC","doi-asserted-by":"publisher","award":["535903"],"award-info":[{"award-number":["535903"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sci. Signal."],"published-print":{"date-parts":[[2015,2,17]]},"abstract":"<jats:p>Without the protein phosphatase PTPN14, tumor cells secrete more prometastatic factors and send more growth-promoting receptors to the surface.<\/jats:p>","DOI":"10.1126\/scisignal.2005547","type":"journal-article","created":{"date-parts":[[2015,2,17]],"date-time":"2015-02-17T16:39:04Z","timestamp":1424191144000},"source":"Crossref","is-referenced-by-count":57,"title":["The tyrosine phosphatase PTPN14 (Pez) inhibits metastasis by altering protein trafficking"],"prefix":"10.1126","volume":"8","author":[{"given":"Leila","family":"Belle","sequence":"first","affiliation":[{"name":"Centre for Cancer Biology, an Alliance between SA Pathology and University of South Australia, Adelaide, South Australia 5000, Australia."},{"name":"Discipline of Biochemistry, School of Molecular and Biomedical Science, The University of Adelaide, Adelaide, South Australia 5005, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naveid","family":"Ali","sequence":"additional","affiliation":[{"name":"Cancer Research Program, Garvan Institute of Medical Research, Darlinghurst, New South Wales 2010, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Lonic","sequence":"additional","affiliation":[{"name":"Centre for Cancer Biology, an Alliance between SA Pathology and University of South Australia, Adelaide, South Australia 5000, Australia."},{"name":"Department of Medicine, The University of Adelaide, Adelaide, South Australia 5005, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaochun","family":"Li","sequence":"additional","affiliation":[{"name":"Centre for Cancer Biology, an Alliance between SA Pathology and University of South Australia, Adelaide, South Australia 5000, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James L.","family":"Paltridge","sequence":"additional","affiliation":[{"name":"Centre for Cancer Biology, an Alliance between SA Pathology and University of South Australia, Adelaide, South Australia 5000, Australia."},{"name":"Discipline of Biochemistry, School of Molecular and Biomedical Science, The University of Adelaide, Adelaide, South Australia 5005, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suraya","family":"Roslan","sequence":"additional","affiliation":[{"name":"Centre for Cancer Biology, an Alliance between SA Pathology and University of South Australia, Adelaide, South Australia 5000, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Herrmann","sequence":"additional","affiliation":[{"name":"Cancer Research Program, The Kinghorn Cancer Centre, Garvan Institute of Medical Research, Darlinghurst, New South Wales 2010, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James R.","family":"W. Conway","sequence":"additional","affiliation":[{"name":"Cancer Research Program, The Kinghorn Cancer Centre, Garvan Institute of Medical Research, Darlinghurst, New South Wales 2010, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Freya K.","family":"Gehling","sequence":"additional","affiliation":[{"name":"Centre for Cancer Biology, an Alliance between SA Pathology and University of South Australia, Adelaide, South Australia 5000, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew G.","family":"Bert","sequence":"additional","affiliation":[{"name":"Centre for Cancer Biology, an Alliance between SA Pathology and University of South Australia, Adelaide, South Australia 5000, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lesley A.","family":"Crocker","sequence":"additional","affiliation":[{"name":"Centre for Cancer Biology, an Alliance between SA Pathology and University of South Australia, Adelaide, South Australia 5000, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Tsykin","sequence":"additional","affiliation":[{"name":"Centre for Cancer Biology, an Alliance between SA Pathology and University of South Australia, Adelaide, South Australia 5000, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gelareh","family":"Farshid","sequence":"additional","affiliation":[{"name":"Division of Tissue Pathology, SA Pathology, Adelaide, South Australia 5000, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory J.","family":"Goodall","sequence":"additional","affiliation":[{"name":"Centre for Cancer Biology, an Alliance between SA Pathology and University of South Australia, Adelaide, South Australia 5000, Australia."},{"name":"Department of Medicine, The University of Adelaide, Adelaide, South Australia 5005, Australia."},{"name":"School and Molecular and Biomedical Science, The University of Adelaide, Adelaide, South Australia 5005, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Timpson","sequence":"additional","affiliation":[{"name":"Cancer Research Program, The Kinghorn Cancer Centre, Garvan Institute of Medical Research, Darlinghurst, New South Wales 2010, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roger J.","family":"Daly","sequence":"additional","affiliation":[{"name":"Cancer Research Program, Garvan Institute of Medical Research, Darlinghurst, New South Wales 2010, Australia."},{"name":"Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria 3800, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yeesim","family":"Khew-Goodall","sequence":"additional","affiliation":[{"name":"Centre for Cancer Biology, an Alliance between SA Pathology and University of South Australia, Adelaide, South Australia 5000, Australia."},{"name":"Discipline of Biochemistry, School of Molecular and Biomedical Science, The University of Adelaide, Adelaide, South Australia 5005, Australia."},{"name":"Department of Medicine, The University of Adelaide, Adelaide, South Australia 5005, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2011.02.013"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcancer.2011.01.002"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature04186"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2753"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jprot.2010.07.001"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1074\/mcp.M112.020933"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2012.02.022"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1021\/pr200584y"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.382"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncb2396"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncb2431"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1995.1591"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200705035"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2012.01.019"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2010.08.008"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1096096"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1133427"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng.903"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.e02-09-0577"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2012.147"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2012.220"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.274.18.12905"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0061916"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1101\/gad.192955.112"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2012.231"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.e11-02-0103"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2006.10.008"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature03799"},{"key":"e_1_3_2_30_2","first-page":"e3089","article-title":"Organotypic collagen I assay: A malleable platform to assess cell behaviour in a 3-dimensional context","author":"Timpson P.","year":"2011","unstructured":"Timpson P., McGhee E. J., Erami Z., Nobis M., Quinn J. A., Edward M., Anderson K. I., Organotypic collagen I assay: A malleable platform to assess cell behaviour in a 3-dimensional context. J. Vis. Exp., e3089 (2011).","journal-title":"J. Vis. Exp."},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrc2618"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrc2621"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20061548"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1534-5807(01)00008-9"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M304324200"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0801174105"},{"key":"e_1_3_2_37_2","doi-asserted-by":"crossref","first-page":"5887","DOI":"10.1242\/jcs.113688","article-title":"RIN1 orchestrates the activation of Rab5 GTPases and ABL tyrosine kinases to determine the fate of EGFR","volume":"125","author":"Balaji K.","year":"2012","unstructured":"Balaji K., Mooser C., Janson C. M., Bliss J. M., Hojjat H., Colicelli J., RIN1 orchestrates the activation of Rab5 GTPases and ABL tyrosine kinases to determine the fate of EGFR. J. Cell Sci. 125, 5887\u20135896 (2012).","journal-title":"J. Cell Sci."},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1100\/tsw.2010.214"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymgme.2006.04.017"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.e07-05-0411"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-13-0131"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2013.59"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1007\/s13277-012-0402-7"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1007\/s13277-012-0409-0"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1007\/s13277-011-0311-1"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.acthis.2011.08.008"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2005.03.049"},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M804002200"},{"key":"e_1_3_2_49_2","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2013.370"},{"key":"e_1_3_2_50_2","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-10-0911"},{"key":"e_1_3_2_51_2","doi-asserted-by":"publisher","DOI":"10.1021\/pr101065j"},{"key":"e_1_3_2_52_2","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.2019"},{"key":"e_1_3_2_53_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2012.04.005"},{"key":"e_1_3_2_54_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2011.08.028"},{"key":"e_1_3_2_55_2","doi-asserted-by":"crossref","first-page":"5887","DOI":"10.1242\/jcs.113688","article-title":"RIN1 orchestrates the activation of Rab5 GTPases and ABL tyrosine kinases to determine EGFR fate","volume":"125","author":"Balaji K.","year":"2012","unstructured":"Balaji K., Mooser C., Janson C. M., Bliss J. M., Hojjat H., Colicelli J., RIN1 orchestrates the activation of Rab5 GTPases and ABL tyrosine kinases to determine EGFR fate. J. Cell Sci. 125, 5887\u20135896 (2012).","journal-title":"J. Cell Sci."},{"key":"e_1_3_2_56_2","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.e10-07-0637"},{"key":"e_1_3_2_57_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1432-1327.1999.00441.x"},{"key":"e_1_3_2_58_2","doi-asserted-by":"publisher","DOI":"10.1042\/bj3590497"},{"key":"e_1_3_2_59_2","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1993.tb05715.x"},{"key":"e_1_3_2_60_2","doi-asserted-by":"publisher","DOI":"10.1021\/bi900492d"},{"key":"e_1_3_2_61_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M109.064923"},{"key":"e_1_3_2_62_2","doi-asserted-by":"publisher","DOI":"10.1210\/endo.139.12.6379"},{"key":"e_1_3_2_63_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M002367200"}],"container-title":["Science Signaling"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/scisignal.2005547","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,16]],"date-time":"2024-01-16T06:19:58Z","timestamp":1705385998000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/scisignal.2005547"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,2,17]]},"references-count":62,"journal-issue":{"issue":"364","published-print":{"date-parts":[[2015,2,17]]}},"alternative-id":["10.1126\/scisignal.2005547"],"URL":"https:\/\/doi.org\/10.1126\/scisignal.2005547","relation":{},"ISSN":["1945-0877","1937-9145"],"issn-type":[{"value":"1945-0877","type":"print"},{"value":"1937-9145","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,2,17]]}}}