{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T05:24:10Z","timestamp":1783056250971,"version":"3.54.6"},"reference-count":56,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"392","license":[{"start":{"date-parts":[[2016,9,1]],"date-time":"2016-09-01T00:00:00Z","timestamp":1472688000000},"content-version":"vor","delay-in-days":366,"URL":"http:\/\/www.sciencemag.org\/about\/science-licenses-journal-article-reuse"}],"funder":[{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["CA099997"],"award-info":[{"award-number":["CA099997"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["AI28847"],"award-info":[{"award-number":["AI28847"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["P50 CA97274"],"award-info":[{"award-number":["P50 CA97274"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["DK050824"],"award-info":[{"award-number":["DK050824"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["P30CA086862"],"award-info":[{"award-number":["P30CA086862"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["T32 AI007260"],"award-info":[{"award-number":["T32 AI007260"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sci. Signal."],"published-print":{"date-parts":[[2015,9]]},"abstract":"<jats:p>TRAF3 tamps down B cell responsiveness to IL-6 to prevent excessive generation of antibody-producing cells.<\/jats:p>","DOI":"10.1126\/scisignal.aaa5157","type":"journal-article","created":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T18:38:59Z","timestamp":1441132739000},"source":"Crossref","is-referenced-by-count":48,"title":["The adaptor protein TRAF3 inhibits interleukin-6 receptor signaling in B cells to limit plasma cell development"],"prefix":"10.1126","volume":"8","author":[{"given":"Wai W.","family":"Lin","sequence":"first","affiliation":[{"name":"Graduate Immunology Program, University of Iowa, Iowa City, IA 52242, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zuoan","family":"Yi","sequence":"additional","affiliation":[{"name":"Department of Microbiology, University of Iowa, Iowa City, IA 52242, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura L.","family":"Stunz","sequence":"additional","affiliation":[{"name":"Department of Microbiology, University of Iowa, Iowa City, IA 52242, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian J.","family":"Maine","sequence":"additional","affiliation":[{"name":"Department of Immunology and Microbial Sciences, The Scripps Research Institute, La Jolla, CA 92037, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda A.","family":"Sherman","sequence":"additional","affiliation":[{"name":"Department of Immunology and Microbial Sciences, The Scripps Research Institute, La Jolla, CA 92037, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gail A.","family":"Bishop","sequence":"additional","affiliation":[{"name":"Graduate Immunology Program, University of Iowa, Iowa City, IA 52242, USA."},{"name":"Department of Microbiology, University of Iowa, Iowa City, IA 52242, USA."},{"name":"Department of Internal Medicine, University of Iowa, Iowa City, IA 52242, USA."},{"name":"Veterans Affairs Medical Center, Iowa City, IA 52246, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cytogfr.2013.12.002"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1000290"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni.2944"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20100703"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2008.01.009"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2007.07.012"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2011.309"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-08-3701"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.3816\/CLM.2009.n.009"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2015.03.059"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng.892"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2007.07.004"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2007.07.003"},{"key":"e_1_3_2_15_2","doi-asserted-by":"crossref","first-page":"556","DOI":"10.4049\/jimmunol.155.2.556","article-title":"Cellular interaction in germinal centers. Roles of CD40 ligand and B7-2 in established germinal centers","volume":"155","author":"Han S.","year":"1995","unstructured":"Han S., Hathcock K., Zheng B., Kepler T. B., Hodes R., Kelsoe G., Cellular interaction in germinal centers. Roles of CD40 ligand and B7-2 in established germinal centers. J. Immunol. 155, 556\u2013567 (1995).","journal-title":"J. Immunol."},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20061254"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/imr.12011"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V97.6.1817"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.173.3.705"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(03)00208-5"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.86.19.7547"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1038\/332083a0"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V77.12.2794.2794"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1159\/000354194"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2009.10.015"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.8511589"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1042\/bj20030407"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri1226"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1301559"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.smim.2007.12.002"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-immunol-032713-120249"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI66963"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI45790"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1092138"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-01-403162"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI57158"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/dxh396"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2009.10.008"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20091777"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2013.06.013"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2014.11.003"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri3581"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2008.11.038"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20061548"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1002\/1521-4141(2000)30:8<2412::AID-IMMU2412>3.0.CO;2-J"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-9822(02)00697-8"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.22.16.5662-5668.2002"},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri1572"},{"key":"e_1_3_2_49_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.180.7.4805"},{"key":"e_1_3_2_50_2","doi-asserted-by":"publisher","DOI":"10.1038\/368339a0"},{"key":"e_1_3_2_51_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V86.4.1243.bloodjournal8641243"},{"key":"e_1_3_2_52_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1208421"},{"key":"e_1_3_2_53_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20081571"},{"key":"e_1_3_2_54_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1302418"},{"key":"e_1_3_2_55_2","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2014.260"},{"key":"e_1_3_2_56_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20031255"},{"key":"e_1_3_2_57_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2013.00477"}],"container-title":["Science Signaling"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/scisignal.aaa5157","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,16]],"date-time":"2024-01-16T10:42:03Z","timestamp":1705401723000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/scisignal.aaa5157"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,9]]},"references-count":56,"journal-issue":{"issue":"392","published-print":{"date-parts":[[2015,9]]}},"alternative-id":["10.1126\/scisignal.aaa5157"],"URL":"https:\/\/doi.org\/10.1126\/scisignal.aaa5157","relation":{},"ISSN":["1945-0877","1937-9145"],"issn-type":[{"value":"1945-0877","type":"print"},{"value":"1937-9145","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,9]]}}}