{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T10:44:38Z","timestamp":1778323478427,"version":"3.51.4"},"reference-count":54,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"430","license":[{"start":{"date-parts":[[2017,5,31]],"date-time":"2017-05-31T00:00:00Z","timestamp":1496188800000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/www.sciencemag.org\/about\/science-licenses-journal-article-reuse"}],"funder":[{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["DA008863"],"award-info":[{"award-number":["DA008863"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["NS026880"],"award-info":[{"award-number":["NS026880"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["DA026434"],"award-info":[{"award-number":["DA026434"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sci. Signal."],"published-print":{"date-parts":[[2016,5,31]]},"abstract":"<jats:p>Stimulation of the receptor GPR171 with a small-molecule ligand results in hyperphagia and weight gain in mice.<\/jats:p>","DOI":"10.1126\/scisignal.aac8035","type":"journal-article","created":{"date-parts":[[2016,5,31]],"date-time":"2016-05-31T18:43:32Z","timestamp":1464720212000},"source":"Crossref","is-referenced-by-count":32,"title":["Identification of a small-molecule ligand that activates the neuropeptide receptor GPR171 and increases food intake"],"prefix":"10.1126","volume":"9","author":[{"given":"Jonathan H.","family":"Wardman","sequence":"first","affiliation":[{"name":"Department of Pharmacology and Systems Therapeutics, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ivone","family":"Gomes","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Systems Therapeutics, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erin N.","family":"Bobeck","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Systems Therapeutics, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer A.","family":"Stockert","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Systems Therapeutics, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abhijeet","family":"Kapoor","sequence":"additional","affiliation":[{"name":"Department of Structural and Chemical Biology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paola","family":"Bisignano","sequence":"additional","affiliation":[{"name":"Department of Structural and Chemical Biology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Achla","family":"Gupta","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Systems Therapeutics, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mihaly","family":"Mezei","sequence":"additional","affiliation":[{"name":"Department of Structural and Chemical Biology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sanjai","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biochemistry, Queens College, Flushing, NY 11367, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marta","family":"Filizola","sequence":"additional","affiliation":[{"name":"Department of Structural and Chemical Biology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lakshmi A.","family":"Devi","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Systems Therapeutics, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1039\/c003317k"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2005.03138.x"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1677\/joe.0.1800357"},{"key":"e_1_3_2_5_2","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1111\/j.1471-4159.2010.06706.x","article-title":"The propeptide precursor proSAAS is involved in fetal neuropeptide processing and body weight regulation","volume":"113","author":"Morgan D. J.","year":"2010","unstructured":"Morgan D. J., Wei S., Gomes I., Czyzyk T., Mzhavia N., Pan H., Devi L. A., Fricker L. D., Pintar J. E., The propeptide precursor proSAAS is involved in fetal neuropeptide processing and body weight regulation. J. Neurochem. 113, 1275\u20131284 (2010).","journal-title":"J. Neurochem."},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0028152"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1312938110"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.5483\/BMBRep.2015.48.4.272"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2013.11.002"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnbeh.2014.00057"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI46229"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2013.09.009"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/nn.2739"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ympev.2014.01.022"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.exphem.2012.09.007"},{"key":"e_1_3_2_16_2","unstructured":"I. Gomes J. H. Wardman S. D. J. Stockton L. A. Devi in Neuropeptide Receptors L. Devi D. F. Lloyd Eds. (Morgan & Claypool Life Sciences Princeton NJ 2013) vol. 4 pp. 1\u2013153."},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11302-004-5071-6"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature13288"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature13083"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature14287"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1043-9471(05)80049-7"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1006\/jmbi.1994.1052"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcc.540150503"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(86)91341-7"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M602516200"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-291X(05)80157-3"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0700859"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.aad0694"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.2174\/156802607780906636"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1002\/emmm.201000100"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1242\/dmm.009621"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.2174\/1568026615666150701112853"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1038\/nchembio.662"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature15699"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1115524"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2006.01.003"},{"key":"e_1_3_2_37_2","doi-asserted-by":"crossref","unstructured":"Pajouhesh H. Lenz G. R. Medicinal chemical properties of successful central nervous system drugs. 2 541\u2013553 (2005).","DOI":"10.1602\/neurorx.2.4.541"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.4137\/PMC.S13384"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M609254200"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymeth.2004.07.003"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2164-8-338"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gku469"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkn072"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1006\/jmbi.1993.1626"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1110\/ps.062416606"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.1021\/jp003919d"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-987X(199604)17:5\/6<587::AID-JCC4>3.0.CO;2-Q"},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.1006\/jsbi.1996.0022"},{"key":"e_1_3_2_49_2","unstructured":"M. A. Totrov R. Abagyan in Drug-Receptor Thermodynamics: Introduction and Applications . R. B. Raffa Ed. (John Wiley & Sons Ltd. New York 2001) pp. 603\u2013624."},{"key":"e_1_3_2_50_2","doi-asserted-by":"publisher","DOI":"10.1021\/jm0300173"},{"key":"e_1_3_2_51_2","doi-asserted-by":"publisher","DOI":"10.1096\/fj.09-132142"},{"key":"e_1_3_2_52_2","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.2000807"},{"key":"e_1_3_2_53_2","first-page":"157","article-title":"Opioid receptor oligomerization. Detection and functional characterization of interacting receptors","volume":"84","author":"Gomes I.","year":"2003","unstructured":"Gomes I., Filipovska J., Devi L. A., Opioid receptor oligomerization. Detection and functional characterization of interacting receptors. Methods Mol. Med. 84, 157\u2013183 (2003).","journal-title":"Methods Mol. Med."},{"key":"e_1_3_2_54_2","doi-asserted-by":"publisher","DOI":"10.1038\/emboj.2011.139"},{"key":"e_1_3_2_55_2","unstructured":"G. Paxinos K. B. J. Franklin The Mouse Brain in Stereotaxic Coordinates (Academic Press San Diego CA 2001)."}],"container-title":["Science Signaling"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/scisignal.aac8035","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,16]],"date-time":"2024-01-16T11:59:02Z","timestamp":1705406342000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/scisignal.aac8035"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,5,31]]},"references-count":54,"journal-issue":{"issue":"430","published-print":{"date-parts":[[2016,5,31]]}},"alternative-id":["10.1126\/scisignal.aac8035"],"URL":"https:\/\/doi.org\/10.1126\/scisignal.aac8035","relation":{},"ISSN":["1945-0877","1937-9145"],"issn-type":[{"value":"1945-0877","type":"print"},{"value":"1937-9145","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,5,31]]}}}