{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T05:49:20Z","timestamp":1784180960904,"version":"3.55.0"},"reference-count":59,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"413","license":[{"start":{"date-parts":[[2017,2,2]],"date-time":"2017-02-02T00:00:00Z","timestamp":1485993600000},"content-version":"vor","delay-in-days":366,"URL":"http:\/\/www.sciencemag.org\/about\/science-licenses-journal-article-reuse"}],"funder":[{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["R01 CA155160"],"award-info":[{"award-number":["R01 CA155160"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["CA174643"],"award-info":[{"award-number":["CA174643"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["UL1TR001117"],"award-info":[{"award-number":["UL1TR001117"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sci. Signal."],"published-print":{"date-parts":[[2016,2,2]]},"abstract":"<jats:p>ABL kinase inhibitors could prevent breast cancer cells from breaking down bone to promote metastasis.<\/jats:p>","DOI":"10.1126\/scisignal.aad3210","type":"journal-article","created":{"date-parts":[[2016,2,2]],"date-time":"2016-02-02T20:58:01Z","timestamp":1454446681000},"source":"Crossref","is-referenced-by-count":53,"title":["ABL kinases promote breast cancer osteolytic metastasis by modulating tumor-bone interactions through TAZ and STAT5 signaling"],"prefix":"10.1126","volume":"9","author":[{"given":"Jun","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, NC 27710, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clay","family":"Rouse","sequence":"additional","affiliation":[{"name":"Division of Laboratory Animal Resources, Duke University School of Medicine, Durham, NC 27710, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeff S.","family":"Jasper","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, NC 27710, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann Marie","family":"Pendergast","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, NC 27710, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.039859"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.3139re6"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-230X(02)85003-5"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.22.012703.104753"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrc3563"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1177\/1947601912458586"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0095663"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2012.284"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1210543"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1210714"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrc3055"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-13-1590"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10555-006-9035-x"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-12-0095"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1593\/neo.07112"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature11412"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tem.2014.10.001"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature08021"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1535-6108(03)00132-6"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1304188110"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M110.147330"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2010.12.022"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2011.11.004"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M109.026633"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature08675"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra030831"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2012.10.005"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2009.05.017"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrc821"},{"key":"e_1_3_2_31_2","first-page":"2704","article-title":"Ewing\u2019s sarcoma family tumors are sensitive to tumor necrosis factor-related apoptosis-inducing ligand and express death receptor 4 and death receptor 5","volume":"61","author":"Mitsiades N.","year":"2001","unstructured":"Mitsiades N., Poulaki V., Mitsiades C., Tsokos M., Ewing\u2019s sarcoma family tumors are sensitive to tumor necrosis factor-related apoptosis-inducing ligand and express death receptor 4 and death receptor 5. Cancer Res. 61, 2704\u20132712 (2001).","journal-title":"Cancer Res."},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80209-3"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1101\/gad.1824809"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.90.24.11924"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.182.5.1461"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.cr.7290266"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.24781"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0506580102"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0049401"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2011.09.048"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2012.11.027"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0909333107"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncb3216"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2007.12.022"},{"key":"e_1_3_2_45_2","first-page":"104","article-title":"The role of Stat5 transcription factors as tumor suppressors or oncogenes","volume":"1815","author":"Ferbeyre G.","year":"2011","unstructured":"Ferbeyre G., Moriggl R., The role of Stat5 transcription factors as tumor suppressors or oncogenes. Biochim. Biophys. Acta 1815, 104\u2013114 (2011).","journal-title":"Biochim. Biophys. Acta"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V94.3.1108.415k07_1108_1112"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.1677\/ERC-09-0328"},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2012.10.023"},{"key":"e_1_3_2_49_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1205484"},{"key":"e_1_3_2_50_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2379"},{"key":"e_1_3_2_51_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.10833"},{"key":"e_1_3_2_52_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2010.02.026"},{"key":"e_1_3_2_53_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2012.06.014"},{"key":"e_1_3_2_54_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0054211"},{"key":"e_1_3_2_55_2","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.2542"},{"key":"e_1_3_2_56_2","doi-asserted-by":"publisher","DOI":"10.1593\/neo.122044"},{"key":"e_1_3_2_57_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-004-3974-0"},{"key":"e_1_3_2_58_2","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdn352"},{"key":"e_1_3_2_59_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.trecan.2015.07.004"},{"key":"e_1_3_2_60_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0085231"}],"container-title":["Science Signaling"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/scisignal.aad3210","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,16]],"date-time":"2024-01-16T10:37:14Z","timestamp":1705401434000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/scisignal.aad3210"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,2,2]]},"references-count":59,"journal-issue":{"issue":"413","published-print":{"date-parts":[[2016,2,2]]}},"alternative-id":["10.1126\/scisignal.aad3210"],"URL":"https:\/\/doi.org\/10.1126\/scisignal.aad3210","relation":{},"ISSN":["1945-0877","1937-9145"],"issn-type":[{"value":"1945-0877","type":"print"},{"value":"1937-9145","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,2,2]]}}}