{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T07:22:56Z","timestamp":1792480976044,"version":"4.5.0"},"reference-count":61,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"468","license":[{"start":{"date-parts":[[2018,2,28]],"date-time":"2018-02-28T00:00:00Z","timestamp":1519776000000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/www.sciencemag.org\/about\/science-licenses-journal-article-reuse"}],"funder":[{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["award289505"],"award-info":[{"award-number":["award289505"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["RO1 HL122547,RO1 HL 102368,RO1 HL114775,RO1 HL 094677,RO1 HL 135886"],"award-info":[{"award-number":["RO1 HL122547,RO1 HL 102368,RO1 HL114775,RO1 HL 094677,RO1 HL 135886"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005310","name":"Klarman Family Foundation","doi-asserted-by":"publisher","award":["award289506"],"award-info":[{"award-number":["award289506"]}],"id":[{"id":"10.13039\/100005310","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sci. Signal."],"published-print":{"date-parts":[[2017,2,28]]},"abstract":"<jats:p>The mTORC1 inhibitor DDiT4L prevents the increase in heart size caused by stress.<\/jats:p>","DOI":"10.1126\/scisignal.aaf5967","type":"journal-article","created":{"date-parts":[[2017,3,1]],"date-time":"2017-03-01T00:04:38Z","timestamp":1488326678000},"source":"Crossref","is-referenced-by-count":59,"title":["DDiT4L promotes autophagy and inhibits pathological cardiac hypertrophy in response to stress"],"prefix":"10.1126","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3190-4796","authenticated-orcid":false,"given":"Bridget","family":"Simonson","sequence":"first","affiliation":[{"name":"Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA 02114, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vinita","family":"Subramanya","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Institute, Beth Israel Deaconess Medical Center, Boston, MA 02115, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mun Chun","family":"Chan","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA 02114, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aifeng","family":"Zhang","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA 02114, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannabeth","family":"Franchino","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Institute, Beth Israel Deaconess Medical Center, Boston, MA 02115, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1540-7447","authenticated-orcid":false,"given":"Filomena","family":"Ottaviano","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Institute, Beth Israel Deaconess Medical Center, Boston, MA 02115, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manoj K.","family":"Mishra","sequence":"additional","affiliation":[{"name":"Department of Physiology, Pennsylvania Muscle Institute, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashley C.","family":"Knight","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Institute, Beth Israel Deaconess Medical Center, Boston, MA 02115, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3557-4915","authenticated-orcid":false,"given":"Danielle","family":"Hunt","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Institute, Beth Israel Deaconess Medical Center, Boston, MA 02115, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6655-3298","authenticated-orcid":false,"given":"Ionita","family":"Ghiran","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Institute, Beth Israel Deaconess Medical Center, Boston, MA 02115, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tejvir S.","family":"Khurana","sequence":"additional","affiliation":[{"name":"Department of Physiology, Pennsylvania Muscle Institute, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria I.","family":"Kontaridis","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Institute, Beth Israel Deaconess Medical Center, Boston, MA 02115, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony","family":"Rosenzweig","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA 02114, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4521-4606","authenticated-orcid":false,"given":"Saumya","family":"Das","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA 02114, USA."},{"name":"Cardiovascular Research Institute, Beth Israel Deaconess Medical Center, Boston, MA 02115, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/cdd.2008.163"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10741-012-9367-2"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.114.302022"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibs.2013.01.004"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.110.977066"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0054221"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M112.423640"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00338.2010"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.113.003638"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.111.078212"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI44972"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.C400557200"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00464.2008"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1101\/gad.322704"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1101\/gad.1256804"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.113.000649"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.112.115592"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M200347200"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI23073"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0606383103"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrm1983"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20041888"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI27523"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3322"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1157535"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2010.02.024"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2014.01.005"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellsig.2006.12.014"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M109.047688"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.2001.280.4.H1782"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.2005262"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000065442.64694.9F"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.113.000016"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvr144"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2010.11.036"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000261924.76669.36"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI71171"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI43008"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.soc.2013.06.008"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1007\/s13238-014-0021-8"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.115.020502"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2014.03.016"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1042\/CS20130260"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymeth.2014.11.014"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M109.080796"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.4161\/auto.27344"},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms5004"},{"key":"e_1_3_2_49_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00711.2014"},{"key":"e_1_3_2_50_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.21197"},{"key":"e_1_3_2_51_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1934654100"},{"key":"e_1_3_2_52_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.cdd.4402095"},{"key":"e_1_3_2_53_2","doi-asserted-by":"publisher","DOI":"10.1021\/bi902135e"},{"key":"e_1_3_2_54_2","first-page":"773","article-title":"Plasma membrane translocation of REDD1 governed by GPCRs contributes to mTORC1 activation","volume":"127","author":"Michel G.","year":"2014","unstructured":"G. Michel, H. W. D. Matthes, M. Hachet-Haas, K. El Baghdadi, J. de Mey, R. Pepperkok, J. C. Simpson, J.-L. Galzi, S. Lecat, Plasma membrane translocation of REDD1 governed by GPCRs contributes to mTORC1 activation. J. Cell Sci. 127, 773\u2013787 (2014).","journal-title":"J. Cell Sci."},{"key":"e_1_3_2_55_2","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2007.135"},{"key":"e_1_3_2_56_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1137325"},{"key":"e_1_3_2_57_2","first-page":"Unit 4.12","article-title":"Construction of normalized RNA-seq libraries for next-generation sequencing using the crab duplex-specific nuclease","volume":"4","author":"Christodoulou D. C.","year":"2011","unstructured":"D. C. Christodoulou, J. M. Gorham, D. S. Herman, J. G. Seidman, Construction of normalized RNA-seq libraries for next-generation sequencing using the crab duplex-specific nuclease. Curr. Protoc. Mol. Biol. Chapter 4, Unit 4.12 (2011).","journal-title":"Curr. Protoc. Mol. Biol."},{"key":"e_1_3_2_58_2","doi-asserted-by":"publisher","DOI":"10.1101\/gr.7.10.986"},{"key":"e_1_3_2_59_2","doi-asserted-by":"publisher","DOI":"10.1038\/nn.2477"},{"key":"e_1_3_2_60_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2013.12.014"},{"key":"e_1_3_2_61_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2013.04.023"},{"key":"e_1_3_2_62_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M506096200"}],"container-title":["Science Signaling"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/scisignal.aaf5967","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,16]],"date-time":"2024-01-16T12:39:16Z","timestamp":1705408756000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/scisignal.aaf5967"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,2,28]]},"references-count":61,"journal-issue":{"issue":"468","published-print":{"date-parts":[[2017,2,28]]}},"alternative-id":["10.1126\/scisignal.aaf5967"],"URL":"https:\/\/doi.org\/10.1126\/scisignal.aaf5967","relation":{},"ISSN":["1945-0877","1937-9145"],"issn-type":[{"value":"1945-0877","type":"print"},{"value":"1937-9145","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,2,28]]},"article-number":"eaaf5967"}}