{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T21:26:11Z","timestamp":1790630771599,"version":"4.1.0"},"reference-count":61,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"492","funder":[{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["award313908"],"award-info":[{"award-number":["award313908"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["HL135821"],"award-info":[{"award-number":["HL135821"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["award313909"],"award-info":[{"award-number":["award313909"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["HL126913"],"award-info":[{"award-number":["HL126913"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["award313910"],"award-info":[{"award-number":["award313910"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["HL094465"],"award-info":[{"award-number":["HL094465"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001674","name":"Fondation Leducq","doi-asserted-by":"publisher","award":["award313911"],"award-info":[{"award-number":["award313911"]}],"id":[{"id":"10.13039\/501100001674","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001674","name":"Fondation Leducq","doi-asserted-by":"publisher","award":["SphingoNet"],"award-info":[{"award-number":["SphingoNet"]}],"id":[{"id":"10.13039\/501100001674","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["award313912"],"award-info":[{"award-number":["award313912"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["postdoctoral fellowship"],"award-info":[{"award-number":["postdoctoral fellowship"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sci. Signal."],"published-print":{"date-parts":[[2017,8,15]]},"abstract":"<jats:p>Cardiovascular diseases could be treated by chaperones that deliver the lipid mediator S1P that promotes endothelial function.<\/jats:p>","DOI":"10.1126\/scisignal.aal2722","type":"journal-article","created":{"date-parts":[[2017,8,15]],"date-time":"2017-08-15T14:20:23Z","timestamp":1502806823000},"source":"Crossref","is-referenced-by-count":118,"title":["An engineered S1P chaperone attenuates hypertension and ischemic injury"],"prefix":"10.1126","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7818-4151","authenticated-orcid":false,"given":"Steven L.","family":"Swendeman","sequence":"first","affiliation":[{"name":"Vascular Biology Program, Boston Children\u2019s Hospital, Boston, MA 02115, USA."},{"name":"Department of Surgery, Harvard Medical School, Boston, MA 02115, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuquan","family":"Xiong","sequence":"additional","affiliation":[{"name":"Vascular Biology Program, Boston Children\u2019s Hospital, Boston, MA 02115, USA."},{"name":"Department of Surgery, Harvard Medical School, Boston, MA 02115, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Cantalupo","sequence":"additional","affiliation":[{"name":"Center for Vascular Biology, Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, Cornell University, New York, NY 10065, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Yuan","sequence":"additional","affiliation":[{"name":"Vascular Biology Program, Boston Children\u2019s Hospital, Boston, MA 02115, USA."},{"name":"Department of Surgery, Harvard Medical School, Boston, MA 02115, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1944-8086","authenticated-orcid":false,"given":"Nathalie","family":"Burg","sequence":"additional","affiliation":[{"name":"Center for Vascular Biology, Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, Cornell University, New York, NY 10065, USA."},{"name":"Hospital for Special Surgery, New York, NY 10021, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Hisano","sequence":"additional","affiliation":[{"name":"Vascular Biology Program, Boston Children\u2019s Hospital, Boston, MA 02115, USA."},{"name":"Department of Surgery, Harvard Medical School, Boston, MA 02115, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0454-0699","authenticated-orcid":false,"given":"Andreane","family":"Cartier","sequence":"additional","affiliation":[{"name":"Vascular Biology Program, Boston Children\u2019s Hospital, Boston, MA 02115, USA."},{"name":"Department of Surgery, Harvard Medical School, Boston, MA 02115, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine H.","family":"Liu","sequence":"additional","affiliation":[{"name":"Center for Vascular Biology, Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, Cornell University, New York, NY 10065, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4122-3425","authenticated-orcid":false,"given":"Eric","family":"Engelbrecht","sequence":"additional","affiliation":[{"name":"Vascular Biology Program, Boston Children\u2019s Hospital, Boston, MA 02115, USA."},{"name":"Department of Surgery, Harvard Medical School, Boston, MA 02115, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8499-2278","authenticated-orcid":false,"given":"Victoria","family":"Blaho","sequence":"additional","affiliation":[{"name":"Center for Vascular Biology, Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, Cornell University, New York, NY 10065, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Zhang","sequence":"additional","affiliation":[{"name":"Center for Vascular Biology, Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, Cornell University, New York, NY 10065, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4092-1416","authenticated-orcid":false,"given":"Keisuke","family":"Yanagida","sequence":"additional","affiliation":[{"name":"Vascular Biology Program, Boston Children\u2019s Hospital, Boston, MA 02115, USA."},{"name":"Department of Surgery, Harvard Medical School, Boston, MA 02115, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvain","family":"Galvani","sequence":"additional","affiliation":[{"name":"Vascular Biology Program, Boston Children\u2019s Hospital, Boston, MA 02115, USA."},{"name":"Department of Surgery, Harvard Medical School, Boston, MA 02115, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideru","family":"Obinata","sequence":"additional","affiliation":[{"name":"Gunma University Initiative for Advanced Research, Gunma 371-8511, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jane E.","family":"Salmon","sequence":"additional","affiliation":[{"name":"Hospital for Special Surgery, New York, NY 10021, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2711-7423","authenticated-orcid":false,"given":"Teresa","family":"Sanchez","sequence":"additional","affiliation":[{"name":"Center for Vascular Biology, Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, Cornell University, New York, NY 10065, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annarita","family":"Di Lorenzo","sequence":"additional","affiliation":[{"name":"Center for Vascular Biology, Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, Cornell University, New York, NY 10065, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8355-4065","authenticated-orcid":false,"given":"Timothy","family":"Hla","sequence":"additional","affiliation":[{"name":"Vascular Biology Program, Boston Children\u2019s Hospital, Boston, MA 02115, USA."},{"name":"Department of Surgery, Harvard Medical School, Boston, MA 02115, USA."},{"name":"Center for Vascular Biology, Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, Cornell University, New York, NY 10065, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","first-page":"87","article-title":"Endothelial dysfunction in atherosclerosis","volume":"89","author":"Harrison D. G.","year":"1994","unstructured":"D. G. Harrison, Endothelial dysfunction in atherosclerosis. Basic Res. Cardiol. 89 (suppl. 1), 87\u2013102 (1994).","journal-title":"Basic Res. Cardiol."},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri2171"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00966.2005"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2009.09.009"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrcardio.2015.124"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/MOL.0000000000000161"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2937"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1159\/000334664"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehi186"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.g4379"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.R800034-JLR200"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1096\/fj.201500064"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1103187108"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.aaa2581"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature14462"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm1211"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M704576200"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.12831"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1097\/MOL.0000000000000142"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tem.2008.11.003"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2796.2009.02095.x"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2008.02.007"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2010.09.062"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.279.5356.1552"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI200418004"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M103782200"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M605823200"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.4331\/wjbc.v1.i11.327"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1210\/me.2005-0209"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI71194"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.20088"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.107.165845"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-immunol-020711-075011"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20121090"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3934"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbalip.2008.06.008"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2014.06.028"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvw004"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2015.07.057"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.105.607135"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.115.012427"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.112.667832"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.22186"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2015.00243"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvp137"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.1097\/FJC.0b013e318157a5fe"},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms8893"},{"key":"e_1_3_2_49_2","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.116.233205"},{"key":"e_1_3_2_50_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1416166111"},{"key":"e_1_3_2_51_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.115.016371"},{"key":"e_1_3_2_52_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e31820d5ec1"},{"key":"e_1_3_2_53_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.274.44.31286"},{"key":"e_1_3_2_54_2","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.3047"},{"key":"e_1_3_2_55_2","first-page":"51329","article-title":"A murine model of myocardial ischemia-reperfusion injury through ligation of the left anterior descending artery","author":"Xu Z.","year":"2014","unstructured":"Z. Xu, J. Alloush, E. Beck, N. Weisleder, A murine model of myocardial ischemia-reperfusion injury through ligation of the left anterior descending artery. J. Vis. Exp. 51329 (2014).","journal-title":"J. Vis. Exp."},{"key":"e_1_3_2_56_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms4315"},{"key":"e_1_3_2_57_2","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.85484"},{"key":"e_1_3_2_58_2","first-page":"100","article-title":"Middle cerebral artery occlusion in rats: A neurological and pathological evaluation of a reproducible model","volume":"31","author":"Menzies S. A.","year":"1992","unstructured":"S. A. Menzies, J. T. Hoff, A. L. Betz, Middle cerebral artery occlusion in rats: A neurological and pathological evaluation of a reproducible model. Neurosurgery 31, 100\u2013106 (1992).","journal-title":"Neurosurgery"},{"key":"e_1_3_2_59_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.27.9.1616"},{"key":"e_1_3_2_60_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.31.7.1679"},{"key":"e_1_3_2_61_2","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.1990.47"},{"key":"e_1_3_2_62_2","doi-asserted-by":"publisher","DOI":"10.4172\/2155-9562.1000146"}],"container-title":["Science Signaling"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1126\/scisignal.aal2722","content-type":"unspecified","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/scisignal.aal2722","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,16]],"date-time":"2024-01-16T07:19:54Z","timestamp":1705389594000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/scisignal.aal2722"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8,15]]},"references-count":61,"journal-issue":{"issue":"492","published-print":{"date-parts":[[2017,8,15]]}},"alternative-id":["10.1126\/scisignal.aal2722"],"URL":"https:\/\/doi.org\/10.1126\/scisignal.aal2722","relation":{},"ISSN":["1945-0877","1937-9145"],"issn-type":[{"value":"1945-0877","type":"print"},{"value":"1937-9145","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,8,15]]},"article-number":"eaal2722"}}