{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T22:12:34Z","timestamp":1792534354087,"version":"4.5.0"},"reference-count":86,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"580","funder":[{"DOI":"10.13039\/100000052","name":"NIH Office of the Director","doi-asserted-by":"publisher","award":["OD020142"],"award-info":[{"award-number":["OD020142"]}],"id":[{"id":"10.13039\/100000052","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["K99DK101585"],"award-info":[{"award-number":["K99DK101585"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["P30DK034989"],"award-info":[{"award-number":["P30DK034989"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["P01DK057751"],"award-info":[{"award-number":["P01DK057751"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["P30DK090744"],"award-info":[{"award-number":["P30DK090744"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["R24DK106743"],"award-info":[{"award-number":["R24DK106743"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["P30DK079310"],"award-info":[{"award-number":["P30DK079310"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000738","name":"U.S. Department of Veterans Affairs","doi-asserted-by":"publisher","award":["VA-ORD I01 BX00968"],"award-info":[{"award-number":["VA-ORD I01 BX00968"]}],"id":[{"id":"10.13039\/100000738","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["UL1TR001102"],"award-info":[{"award-number":["UL1TR001102"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000070","name":"National Institute of Biomedical Imaging and Bioengineering","doi-asserted-by":"publisher","award":["F31EB018718"],"award-info":[{"award-number":["F31EB018718"]}],"id":[{"id":"10.13039\/100000070","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["P30DK106912"],"award-info":[{"award-number":["P30DK106912"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sci. Signal."],"published-print":{"date-parts":[[2019,5,7]]},"abstract":"<jats:p>Enhanced mitochondrial function enhances cyst formation in an inherited kidney disease caused by loss of polycystin 2.<\/jats:p>","DOI":"10.1126\/scisignal.aat7397","type":"journal-article","created":{"date-parts":[[2019,5,7]],"date-time":"2019-05-07T23:15:20Z","timestamp":1557270920000},"source":"Crossref","is-referenced-by-count":94,"title":["Polycystin 2 regulates mitochondrial Ca\n            <sup>2+<\/sup>\n            signaling, bioenergetics, and dynamics through mitofusin 2"],"prefix":"10.1126","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9867-2408","authenticated-orcid":true,"given":"Ivana Y.","family":"Kuo","sequence":"first","affiliation":[{"name":"Department of Pharmacology, Yale University School of Medicine, New Haven, CT 06510, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5046-3578","authenticated-orcid":true,"given":"Allison L.","family":"Brill","sequence":"additional","affiliation":[{"name":"Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, CT 06510, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernanda O.","family":"Lemos","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Yale University School of Medicine, New Haven, CT 06510, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8376-0619","authenticated-orcid":true,"given":"Jason Y.","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Surgery, Harvard Medical School, Brigham and Women's Hospital, MA 02132, USA."},{"name":"VA Boston Healthcare System, West Roxbury, MA 02132, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0429-0597","authenticated-orcid":true,"given":"Jeffrey L.","family":"Falcone","sequence":"additional","affiliation":[{"name":"Department of Surgery, Harvard Medical School, Brigham and Women's Hospital, MA 02132, USA."},{"name":"VA Boston Healthcare System, West Roxbury, MA 02132, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erica P.","family":"Kimmerling","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, Tufts University. Medford, MA 02155, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiqiang","family":"Cai","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Yale University School of Medicine. New Haven, CT 06510, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1943-017X","authenticated-orcid":true,"given":"Ke","family":"Dong","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Yale University School of Medicine. New Haven, CT 06510, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9245-7774","authenticated-orcid":true,"given":"David L.","family":"Kaplan","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, Tufts University. Medford, MA 02155, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darren P.","family":"Wallace","sequence":"additional","affiliation":[{"name":"Department of Medicine and the Jared Grantham Kidney Institute, University of Kansas Medical Center, Kansas City, KS 66160, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aldebaran M.","family":"Hofer","sequence":"additional","affiliation":[{"name":"Department of Surgery, Harvard Medical School, Brigham and Women's Hospital, MA 02132, USA."},{"name":"VA Boston Healthcare System, West Roxbury, MA 02132, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9657-9704","authenticated-orcid":true,"given":"Barbara E.","family":"Ehrlich","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Yale University School of Medicine, New Haven, CT 06510, USA."},{"name":"Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, CT 06510, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.1990.70.2.391"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2010.06.007"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcb.2008.12.002"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2009.04.010"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2008.308"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2010.11.023"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrm3440"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceb.2013.02.010"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature10234"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature10230"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M506623200"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1300677110"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.2337\/db13-1751"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrneph.2015.46"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3092"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0146654"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2015030231"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.e16-08-0597"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1038\/emboj.2008.307"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.ASN.0000029587.47950.25"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.274.40.28557"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncb754"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceca.2012.03.002"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M109.090662"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2013040398"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature07534"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.112.266585"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1021\/sb300050j"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddg190"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2010.07576.x"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.051636098"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1038\/35014006"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1038\/358325a0"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2818.2012.03683.x"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chembiol.2006.03.007"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2009.08.045"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkv1003"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1412323111"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00035.2006"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3495(00)76289-8"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1504880112"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceca.2014.11.002"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbabio.2009.01.005"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2016.02.022"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI27794"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2007060688"},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.2000.00991.x"},{"key":"e_1_3_2_49_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00692.2011"},{"key":"e_1_3_2_50_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2007.08.036"},{"key":"e_1_3_2_51_2","doi-asserted-by":"publisher","DOI":"10.18632\/aging.100790"},{"key":"e_1_3_2_52_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0403954101"},{"key":"e_1_3_2_53_2","doi-asserted-by":"publisher","DOI":"10.1016\/0889-1605(85)90132-6"},{"key":"e_1_3_2_54_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2010.06.029"},{"key":"e_1_3_2_55_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1415933111"},{"key":"e_1_3_2_56_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2013.09.003"},{"key":"e_1_3_2_57_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2013.04.023"},{"key":"e_1_3_2_58_2","doi-asserted-by":"publisher","DOI":"10.1093\/abbs\/gmv035"},{"key":"e_1_3_2_59_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1606786113"},{"key":"e_1_3_2_60_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature16500"},{"key":"e_1_3_2_61_2","doi-asserted-by":"publisher","DOI":"10.14814\/phy2.13437"},{"key":"e_1_3_2_62_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0046293"},{"key":"e_1_3_2_63_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI67273"},{"key":"e_1_3_2_64_2","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.e10-05-0407"},{"key":"e_1_3_2_65_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI76972"},{"key":"e_1_3_2_66_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M113.501205"},{"key":"e_1_3_2_67_2","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2012111089"},{"key":"e_1_3_2_68_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-20856-6"},{"key":"e_1_3_2_69_2","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.00337-17"},{"key":"e_1_3_2_70_2","doi-asserted-by":"publisher","DOI":"10.3390\/diseases5010001"},{"key":"e_1_3_2_71_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M405079200"},{"key":"e_1_3_2_72_2","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2005060645"},{"key":"e_1_3_2_73_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1302455110"},{"key":"e_1_3_2_74_2","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.01360210"},{"key":"e_1_3_2_75_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0509694103"},{"key":"e_1_3_2_76_2","doi-asserted-by":"publisher","DOI":"10.1186\/1755-8417-2-6"},{"key":"e_1_3_2_77_2","doi-asserted-by":"publisher","DOI":"10.1159\/000314380"},{"key":"e_1_3_2_78_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature09968"},{"key":"e_1_3_2_79_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3735"},{"key":"e_1_3_2_80_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0120097"},{"key":"e_1_3_2_81_2","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-416618-9.00008-X"},{"key":"e_1_3_2_82_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature12354"},{"key":"e_1_3_2_83_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymeth.2008.09.024"},{"key":"e_1_3_2_84_2","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-391857-4.00009-4"},{"key":"e_1_3_2_85_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.93.18.9893"},{"key":"e_1_3_2_86_2","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddn045"},{"key":"e_1_3_2_87_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm.1865"}],"container-title":["Science Signaling"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1126\/scisignal.aat7397","content-type":"unspecified","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/scisignal.aat7397","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,16]],"date-time":"2024-01-16T13:15:38Z","timestamp":1705410938000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/scisignal.aat7397"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5,7]]},"references-count":86,"journal-issue":{"issue":"580","published-print":{"date-parts":[[2019,5,7]]}},"alternative-id":["10.1126\/scisignal.aat7397"],"URL":"https:\/\/doi.org\/10.1126\/scisignal.aat7397","relation":{},"ISSN":["1945-0877","1937-9145"],"issn-type":[{"value":"1945-0877","type":"print"},{"value":"1937-9145","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,5,7]]},"article-number":"eaat7397"}}