{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T06:36:40Z","timestamp":1790836600356,"version":"4.1.0"},"reference-count":121,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"597","funder":[{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["P-Nut, ANR-16-CE13-0002"],"award-info":[{"award-number":["P-Nut, ANR-16-CE13-0002"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002915","name":"Fondation pour la Recherche M\u00e9dicale","doi-asserted-by":"publisher","award":["SPF20150934065"],"award-info":[{"award-number":["SPF20150934065"]}],"id":[{"id":"10.13039\/501100002915","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004097","name":"Fondation ARC pour la Recherche sur le Cancer","doi-asserted-by":"publisher","award":["PJA20181208080"],"award-info":[{"award-number":["PJA20181208080"]}],"id":[{"id":"10.13039\/501100004097","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Ligue Contre le Cancer - Comit\u00e9 de Paris","award":["TAZK20115"],"award-info":[{"award-number":["TAZK20115"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sci. Signal."],"published-print":{"date-parts":[[2019,9,3]]},"abstract":"<jats:p>An evolutionarily conserved family of phosphatases enables cells to resist the toxic metabolic effects of 2-deoxyglucose.<\/jats:p>","DOI":"10.1126\/scisignal.aaw8000","type":"journal-article","created":{"date-parts":[[2019,9,3]],"date-time":"2019-09-03T23:19:07Z","timestamp":1567552747000},"source":"Crossref","is-referenced-by-count":33,"title":["The induction of HAD-like phosphatases by multiple signaling pathways confers resistance to the metabolic inhibitor 2-deoxyglucose"],"prefix":"10.1126","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2255-4859","authenticated-orcid":true,"given":"Quentin","family":"Defenouill\u00e8re","sequence":"first","affiliation":[{"name":"Institut Jacques Monod, UMR 7592 Centre National de la Recherche Scientifique\/Universit\u00e9 Paris-Diderot, Sorbonne Paris Cit\u00e9, 75205, Paris Cedex 13, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agathe","family":"Verraes","sequence":"additional","affiliation":[{"name":"Institut Jacques Monod, UMR 7592 Centre National de la Recherche Scientifique\/Universit\u00e9 Paris-Diderot, Sorbonne Paris Cit\u00e9, 75205, Paris Cedex 13, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1814-9861","authenticated-orcid":true,"given":"Clotilde","family":"Laussel","sequence":"additional","affiliation":[{"name":"Institut Jacques Monod, UMR 7592 Centre National de la Recherche Scientifique\/Universit\u00e9 Paris-Diderot, Sorbonne Paris Cit\u00e9, 75205, Paris Cedex 13, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Friedrich","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Strasbourg, CNRS, GMGM UMR 7156, 67000 Strasbourg, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Schacherer","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Strasbourg, CNRS, GMGM UMR 7156, 67000 Strasbourg, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2536-8595","authenticated-orcid":true,"given":"S\u00e9bastien","family":"L\u00e9on","sequence":"additional","affiliation":[{"name":"Institut Jacques Monod, UMR 7592 Centre National de la Recherche Scientifique\/Universit\u00e9 Paris-Diderot, Sorbonne Paris Cit\u00e9, 75205, Paris Cedex 13, France."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2008.05.005"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1174229"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1209597"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrd4145"},{"key":"e_1_3_2_6_2","first-page":"71","article-title":"Selective depletion of tumor ATP by 2-deoxyglucose and insulin, detected by 31P magnetic resonance spectroscopy","volume":"52","author":"Karczmar G. S.","year":"1992","unstructured":"G. S. Karczmar, J. M. Arbeit, B. J. Toy, A. Speder, M. W. Weiner, Selective depletion of tumor ATP by 2-deoxyglucose and insulin, detected by 31P magnetic resonance spectroscopy. Cancer Res. 52, 71\u201376 (1992).","journal-title":"Cancer Res."},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/0300-9084(92)90070-U"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)65384-0"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)64988-9"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2014.09.003"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/pros.21172"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.4103\/0973-1482.55136"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00280-012-2045-1"},{"key":"e_1_3_2_14_2","first-page":"164","article-title":"Expression of glucose transporters in cancers","volume":"1835","author":"Szablewski L.","year":"2013","unstructured":"L. Szablewski, Expression of glucose transporters in cancers. Biochim. Biophys. Acta 1835, 164\u2013169 (2013).","journal-title":"Biochim. Biophys. Acta"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1158\/1535-7163.MCT-07-0310"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1004085"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.4.11.1109"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00280-010-1391-0"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1186\/2049-3002-2-9"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20141562"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)93917-7"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbabio.2010.08.010"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.3526554"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1990.tb07479.x"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.16.9.4790"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1111\/1574-6976.12065"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00265579"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00382091"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1128\/jb.170.6.2870-2872.1988"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1093\/genetics\/115.2.247"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0803090105"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1534\/genetics.114.169060"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0926-6593(66)80094-2"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00315774"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1128\/EC.00256-06"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1128\/jb.173.6.2045-2052.1991"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9861(77)90544-6"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)63169-2"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/0304-4165(64)90046-7"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(77)81014-4"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1002\/yea.320111303"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1002\/yea.320100907"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1016\/0304-4165(64)90045-5"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1128\/jb.95.3.1169-1172.1968"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M104418200"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.2741\/2854"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1995.tb00282.x"},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.01183-14"},{"key":"e_1_3_2_49_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.182.18.5121-5126.2000"},{"key":"e_1_3_2_50_2","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/cdg353"},{"key":"e_1_3_2_51_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(82)90241-0"},{"key":"e_1_3_2_52_2","doi-asserted-by":"publisher","DOI":"10.1038\/332462a0"},{"key":"e_1_3_2_53_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81360-4"},{"key":"e_1_3_2_54_2","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a013169"},{"key":"e_1_3_2_55_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkj013"},{"key":"e_1_3_2_56_2","doi-asserted-by":"publisher","DOI":"10.1534\/genetics.111.128264"},{"key":"e_1_3_2_57_2","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.e03-02-0113"},{"key":"e_1_3_2_58_2","doi-asserted-by":"publisher","DOI":"10.1128\/EC.00222-08"},{"key":"e_1_3_2_59_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2010.06.006"},{"key":"e_1_3_2_60_2","doi-asserted-by":"publisher","DOI":"10.1158\/1541-7786.MCR-05-0181"},{"key":"e_1_3_2_61_2","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.e08-08-0809"},{"key":"e_1_3_2_62_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-1033.1975.tb04157.x"},{"key":"e_1_3_2_63_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-1033.1978.tb12630.x"},{"key":"e_1_3_2_64_2","doi-asserted-by":"publisher","DOI":"10.1128\/jb.107.1.121-129.1971"},{"key":"e_1_3_2_65_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrc2676"},{"key":"e_1_3_2_66_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00294-003-0381-8"},{"key":"e_1_3_2_67_2","doi-asserted-by":"publisher","DOI":"10.1002\/yea.1628"},{"key":"e_1_3_2_68_2","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.18.11.6273"},{"key":"e_1_3_2_69_2","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20140734"},{"key":"e_1_3_2_70_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1005491"},{"key":"e_1_3_2_71_2","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.03307"},{"key":"e_1_3_2_72_2","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.e10-06-0513"},{"key":"e_1_3_2_73_2","doi-asserted-by":"publisher","DOI":"10.1002\/prot.21956"},{"key":"e_1_3_2_74_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.89.16.7290"},{"key":"e_1_3_2_75_2","doi-asserted-by":"publisher","DOI":"10.1006\/jmbi.1999.3494"},{"key":"e_1_3_2_76_2","doi-asserted-by":"publisher","DOI":"10.1093\/genetics\/107.1.19"},{"key":"e_1_3_2_77_2","doi-asserted-by":"publisher","DOI":"10.1128\/jb.166.3.1123-1127.1986"},{"key":"e_1_3_2_78_2","doi-asserted-by":"publisher","DOI":"10.1093\/genetics\/137.1.49"},{"key":"e_1_3_2_79_2","first-page":"64","article-title":"Assay for adhesion and agar invasion in S. cerevisiae","author":"Guldal C. G.","year":"2006","unstructured":"C. G. Guldal, J. Broach, Assay for adhesion and agar invasion in S. cerevisiae. J. Vis. Exp., 64 (2006).","journal-title":"J. Vis. Exp."},{"key":"e_1_3_2_80_2","doi-asserted-by":"publisher","DOI":"10.1093\/genetics\/94.4.871"},{"key":"e_1_3_2_81_2","doi-asserted-by":"publisher","DOI":"10.1002\/yea.320110506"},{"key":"e_1_3_2_82_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M605449200"},{"key":"e_1_3_2_83_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/25.17.3389"},{"key":"e_1_3_2_84_2","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20100174"},{"key":"e_1_3_2_85_2","doi-asserted-by":"publisher","DOI":"10.1093\/glycob\/cwj050"},{"key":"e_1_3_2_86_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-4658.2012.08633.x"},{"key":"e_1_3_2_87_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2006.06.049"},{"key":"e_1_3_2_88_2","doi-asserted-by":"publisher","DOI":"10.1016\/0016-0032(52)90852-1"},{"key":"e_1_3_2_89_2","doi-asserted-by":"publisher","DOI":"10.1016\/0016-0032(53)91167-3"},{"key":"e_1_3_2_90_2","first-page":"599","article-title":"The effect of 2-desoxy-D-glucose on glycolysis and respiration of tumor and normal tissues","volume":"14","author":"Woodward G. E.","year":"1954","unstructured":"G. E. Woodward, M. T. Hudson, The effect of 2-desoxy-D-glucose on glycolysis and respiration of tumor and normal tissues. Cancer Res. 14, 599\u2013605 (1954).","journal-title":"Cancer Res."},{"key":"e_1_3_2_91_2","doi-asserted-by":"publisher","DOI":"10.1016\/0016-0032(52)90177-4"},{"key":"e_1_3_2_92_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2005.07.001"},{"key":"e_1_3_2_93_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80835-1"},{"key":"e_1_3_2_94_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1356-9597.2001.00495.x"},{"key":"e_1_3_2_95_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-1033.1974.tb03828.x"},{"key":"e_1_3_2_96_2","doi-asserted-by":"publisher","DOI":"10.1002\/iub.1251"},{"key":"e_1_3_2_97_2","doi-asserted-by":"publisher","DOI":"10.1016\/0304-4165(68)90310-3"},{"key":"e_1_3_2_98_2","doi-asserted-by":"publisher","DOI":"10.1042\/bj3550625"},{"key":"e_1_3_2_99_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-6976.2008.00117.x"},{"key":"e_1_3_2_100_2","doi-asserted-by":"publisher","DOI":"10.1128\/jb.111.2.419-429.1972"},{"key":"e_1_3_2_101_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-5793(00)01480-0"},{"key":"e_1_3_2_102_2","doi-asserted-by":"publisher","DOI":"10.15698\/mic2018.05.630"},{"key":"e_1_3_2_103_2","doi-asserted-by":"publisher","DOI":"10.1101\/gad.9.7.821"},{"key":"e_1_3_2_104_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature02026"},{"key":"e_1_3_2_105_2","doi-asserted-by":"publisher","DOI":"10.2144\/000113672"},{"key":"e_1_3_2_106_2","doi-asserted-by":"publisher","DOI":"10.1016\/0378-1119(87)90376-3"},{"key":"e_1_3_2_107_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00438-001-0604-y"},{"key":"e_1_3_2_108_2","doi-asserted-by":"publisher","DOI":"10.1016\/0378-1119(95)00037-7"},{"key":"e_1_3_2_109_2","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.1511"},{"key":"e_1_3_2_110_2","doi-asserted-by":"publisher","DOI":"10.1021\/pr101065j"},{"key":"e_1_3_2_111_2","doi-asserted-by":"publisher","DOI":"10.1074\/mcp.M113.031591"},{"key":"e_1_3_2_112_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymeth.2010.12.016"},{"key":"e_1_3_2_113_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btp324"},{"key":"e_1_3_2_114_2","doi-asserted-by":"publisher","DOI":"10.1101\/gr.107524.110"},{"key":"e_1_3_2_115_2","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.1754"},{"key":"e_1_3_2_116_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkw880"},{"key":"e_1_3_2_117_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(17)40280-8"},{"key":"e_1_3_2_118_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btm404"},{"key":"e_1_3_2_119_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0061(19980130)14:2<115::AID-YEA204>3.0.CO;2-2"},{"key":"e_1_3_2_120_2","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.1181"},{"key":"e_1_3_2_121_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2958.2002.03198.x"},{"key":"e_1_3_2_122_2","doi-asserted-by":"publisher","DOI":"10.1101\/gad.8.12.1434"}],"container-title":["Science Signaling"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1126\/scisignal.aaw8000","content-type":"unspecified","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/scisignal.aaw8000","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,16]],"date-time":"2024-01-16T12:36:18Z","timestamp":1705408578000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/scisignal.aaw8000"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9,3]]},"references-count":121,"journal-issue":{"issue":"597","published-print":{"date-parts":[[2019,9,3]]}},"alternative-id":["10.1126\/scisignal.aaw8000"],"URL":"https:\/\/doi.org\/10.1126\/scisignal.aaw8000","relation":{},"ISSN":["1945-0877","1937-9145"],"issn-type":[{"value":"1945-0877","type":"print"},{"value":"1937-9145","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,9,3]]},"article-number":"eaaw8000"}}