{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T17:17:11Z","timestamp":1790788631971,"version":"4.1.0"},"reference-count":62,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"627","funder":[{"DOI":"10.13039\/100011713","name":"Worldwide Cancer Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100011713","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Spanish Ministry of Economy and Competitiveness"},{"DOI":"10.13039\/501100001665","name":"French National Research Agency","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"crossref"}]},{"name":"PEPS CNRS"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sci. Signal."],"published-print":{"date-parts":[[2020,4,14]]},"abstract":"<jats:p>Optimal B cell responses depend on balanced signaling between DAG and phosphatidic acid, which is regulated by diacylglycerol kinase \u03b6.<\/jats:p>","DOI":"10.1126\/scisignal.aaw8214","type":"journal-article","created":{"date-parts":[[2020,4,14]],"date-time":"2020-04-14T19:15:16Z","timestamp":1586891716000},"source":"Crossref","is-referenced-by-count":35,"title":["Diacylglycerol kinase \u03b6 promotes actin cytoskeleton remodeling and mechanical forces at the B cell immune synapse"],"prefix":"10.1126","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5227-7429","authenticated-orcid":true,"given":"Sara V.","family":"Merino-Cort\u00e9s","sequence":"first","affiliation":[{"name":"Department of Immunology and Oncology, Centro Nacional de Biotecnolog\u00eda (CNB)-CSIC, Madrid, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sofia R.","family":"Gardeta","sequence":"additional","affiliation":[{"name":"Department of Immunology and Oncology, Centro Nacional de Biotecnolog\u00eda (CNB)-CSIC, Madrid, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Roman-Garcia","sequence":"additional","affiliation":[{"name":"Department of Immunology and Oncology, Centro Nacional de Biotecnolog\u00eda (CNB)-CSIC, Madrid, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6880-3107","authenticated-orcid":true,"given":"Ana","family":"Mart\u00ednez-Ria\u00f1o","sequence":"additional","affiliation":[{"name":"Department of Cell Biology and Immunology, Centro de Biolog\u00eda Molecular Severo Ochoa (CBMSO), CSIC-UAM, Madrid, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0665-1210","authenticated-orcid":true,"given":"Judith","family":"Pineau","sequence":"additional","affiliation":[{"name":"Institut Curie, PSL Research University, INSERM U932, Paris, France."},{"name":"Universit\u00e9 de Paris, 75006, Paris, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2727-8910","authenticated-orcid":true,"given":"Rosa","family":"Liebana","sequence":"additional","affiliation":[{"name":"Department of Immunology and Oncology, Centro Nacional de Biotecnolog\u00eda (CNB)-CSIC, Madrid, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2762-6241","authenticated-orcid":true,"given":"Isabel","family":"Merida","sequence":"additional","affiliation":[{"name":"Department of Immunology and Oncology, Centro Nacional de Biotecnolog\u00eda (CNB)-CSIC, Madrid, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8220-4482","authenticated-orcid":true,"given":"Ana-Maria Lennon","family":"Dumenil","sequence":"additional","affiliation":[{"name":"Institut Curie, PSL Research University, INSERM U932, Paris, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3014-0181","authenticated-orcid":true,"given":"Paolo","family":"Pierobon","sequence":"additional","affiliation":[{"name":"Institut Curie, PSL Research University, INSERM U932, Paris, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8230-1469","authenticated-orcid":true,"given":"Julien","family":"Husson","sequence":"additional","affiliation":[{"name":"Laboratoire d\u2019Hydrodynamique (LadHyx), Ecole polytechnique, CNRS, Institut Polytechnique de Paris, Paris, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Balbino","family":"Alarcon","sequence":"additional","affiliation":[{"name":"Department of Cell Biology and Immunology, Centro de Biolog\u00eda Molecular Severo Ochoa (CBMSO), CSIC-UAM, Madrid, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2148-1926","authenticated-orcid":true,"given":"Yolanda R.","family":"Carrasco","sequence":"additional","affiliation":[{"name":"Department of Immunology and Oncology, Centro Nacional de Biotecnolog\u00eda (CNB)-CSIC, Madrid, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.aaa0974"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2016.00140"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.2004189"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1300684"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(04)00105-0"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.285.5425.221"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/25764"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2006.02.013"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.e11-03-0247"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.2004373"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0908326107"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.25.16.7289-7302.2005"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.e03-03-0190"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201109112"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)78159-9"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.M028597"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature05185"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.aaf7714"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.2005287"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcb.2016.10.005"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.e17-06-0385"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1237572"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20131324"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.e07-12-1248"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.aai9192"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.061051"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2015.00251"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni.3458"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2011.07.008"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.e12-01-0026"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201010059"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.138.6.1265"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1170179"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20011758"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(03)00675-5"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1038\/16711"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.274.39.27359"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/cdg457"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.E14-09-1373"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni.1734"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni.2033"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms10969"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri.2017.74"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201406121"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcb.2006.03.007"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0019680"},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2016.01.021"},{"key":"e_1_3_2_49_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2017.11.023"},{"key":"e_1_3_2_50_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1103028"},{"key":"e_1_3_2_51_2","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-13-2627"},{"key":"e_1_3_2_52_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni958"},{"key":"e_1_3_2_53_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni1400"},{"key":"e_1_3_2_54_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1073560"},{"key":"e_1_3_2_55_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200602142"},{"key":"e_1_3_2_56_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1711.1998.00709.x"},{"key":"e_1_3_2_57_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-01-332106"},{"key":"e_1_3_2_58_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00270.2001"},{"key":"e_1_3_2_59_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms6749"},{"key":"e_1_3_2_60_2","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.1233"},{"key":"e_1_3_2_61_2","doi-asserted-by":"publisher","DOI":"10.1038\/srep21529"},{"key":"e_1_3_2_62_2","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.e16-06-0414"},{"key":"e_1_3_2_63_2","doi-asserted-by":"publisher","DOI":"10.1103\/PhysRevLett.87.148102"}],"container-title":["Science Signaling"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1126\/scisignal.aaw8214","content-type":"unspecified","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/scisignal.aaw8214","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,16]],"date-time":"2024-01-16T06:15:44Z","timestamp":1705385744000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/scisignal.aaw8214"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4,14]]},"references-count":62,"journal-issue":{"issue":"627","published-print":{"date-parts":[[2020,4,14]]}},"alternative-id":["10.1126\/scisignal.aaw8214"],"URL":"https:\/\/doi.org\/10.1126\/scisignal.aaw8214","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.737753129.793574142","asserted-by":"object"}]},"ISSN":["1945-0877","1937-9145"],"issn-type":[{"value":"1945-0877","type":"print"},{"value":"1937-9145","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,4,14]]},"article-number":"eaaw8214"}}