{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T21:30:15Z","timestamp":1790890215781,"version":"4.1.0"},"reference-count":43,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"582","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sci. Signal."],"published-print":{"date-parts":[[2019,5,21]]},"abstract":"<jats:p>Pyroptosis requires the induction of gasdermin D expression by the transcription factor IRF2.<\/jats:p>","DOI":"10.1126\/scisignal.aax4917","type":"journal-article","created":{"date-parts":[[2019,5,21]],"date-time":"2019-05-21T23:24:22Z","timestamp":1558481062000},"source":"Crossref","is-referenced-by-count":184,"title":["IRF2 transcriptionally induces\n            <i>GSDMD<\/i>\n            expression for pyroptosis"],"prefix":"10.1126","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8129-1740","authenticated-orcid":true,"given":"Nobuhiko","family":"Kayagaki","sequence":"first","affiliation":[{"name":"Department of Physiological Chemistry, Genentech Inc., South San Francisco, CA 94080, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bettina L.","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Physiological Chemistry, Genentech Inc., South San Francisco, CA 94080, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irma B.","family":"Stowe","sequence":"additional","affiliation":[{"name":"Department of Physiological Chemistry, Genentech Inc., South San Francisco, CA 94080, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4795-6574","authenticated-orcid":true,"given":"Opher S.","family":"Kornfeld","sequence":"additional","affiliation":[{"name":"Department of Physiological Chemistry, Genentech Inc., South San Francisco, CA 94080, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen","family":"O'Rourke","sequence":"additional","affiliation":[{"name":"Department of Physiological Chemistry, Genentech Inc., South San Francisco, CA 94080, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathleen M.","family":"Mirrashidi","sequence":"additional","affiliation":[{"name":"Department of Physiological Chemistry, Genentech Inc., South San Francisco, CA 94080, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0074-0020","authenticated-orcid":true,"given":"Benjamin","family":"Haley","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology, Genentech Inc., South San Francisco, CA 94080, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colin","family":"Watanabe","sequence":"additional","affiliation":[{"name":"Department of Bioinformatics, Genentech Inc., South San Francisco, CA 94080, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1601-571X","authenticated-orcid":true,"given":"Merone","family":"Roose-Girma","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology, Genentech Inc., South San Francisco, CA 94080, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zora","family":"Modrusan","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology, Genentech Inc., South San Francisco, CA 94080, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0089-2358","authenticated-orcid":true,"given":"Sarah","family":"Kummerfeld","sequence":"additional","affiliation":[{"name":"Department of Bioinformatics, Genentech Inc., South San Francisco, CA 94080, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rohit","family":"Reja","sequence":"additional","affiliation":[{"name":"Department of Bioinformatics, Genentech Inc., South San Francisco, CA 94080, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yafei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Australian Phenomics Facility, John Curtin School of Medical Research, Australian National University, Canberra, ACT 2600, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9039-9876","authenticated-orcid":true,"given":"Vicky","family":"Cho","sequence":"additional","affiliation":[{"name":"Australian Phenomics Facility, John Curtin School of Medical Research, Australian National University, Canberra, ACT 2600, Australia."},{"name":"Department of Immunology and Infectious Disease, John Curtin School of Medical Research, Australian National University, Canberra, ACT 2600, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T. Daniel","family":"Andrews","sequence":"additional","affiliation":[{"name":"Department of Immunology and Infectious Disease, John Curtin School of Medical Research, Australian National University, Canberra, ACT 2600, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucy X.","family":"Morris","sequence":"additional","affiliation":[{"name":"Australian Phenomics Facility, John Curtin School of Medical Research, Australian National University, Canberra, ACT 2600, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5296-6155","authenticated-orcid":true,"given":"Christopher C.","family":"Goodnow","sequence":"additional","affiliation":[{"name":"Garvan Institute of Medical Research, Sydney, NSW 2010, Australia."},{"name":"Faculty of Medicine, UNSW Sydney, Sydney, NSW 2052, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8211-9245","authenticated-orcid":true,"given":"Edward M.","family":"Bertram","sequence":"additional","affiliation":[{"name":"Australian Phenomics Facility, John Curtin School of Medical Research, Australian National University, Canberra, ACT 2600, Australia."},{"name":"Department of Immunology and Infectious Disease, John Curtin School of Medical Research, Australian National University, Canberra, ACT 2600, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6983-0326","authenticated-orcid":true,"given":"Vishva M.","family":"Dixit","sequence":"additional","affiliation":[{"name":"Department of Physiological Chemistry, Genentech Inc., South San Francisco, CA 94080, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1097-2765(02)00599-3"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature10558"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2014.04.007"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/imr.12534"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature15514"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature15541"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature18590"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature18629"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1607769113"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.15252\/embj.201694696"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20172060"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.3000047"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygeno.2007.01.003"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.20636"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(01)00199-6"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature04515"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.26.021607.090400"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri1900"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature03464"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2018.02.055"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M301476200"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20161630"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1240988"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1240248"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(93)90326-L"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80434-1"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(89)90107-4"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(05)80086-8"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-immunol-032713-120231"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M207852200"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2012.07.007"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20180589"},{"key":"e_1_3_2_34_2","first-page":"4531","article-title":"Recognition DNA sequences of interferon regulatory factor 1 (IRF-1) and IRF-2, regulators of cell growth and the interferon system","volume":"13","author":"Tanaka N.","year":"1993","unstructured":"N. Tanaka, T. Kawakami, T. Taniguchi, Recognition DNA sequences of interferon regulatory factor 1 (IRF-1) and IRF-2, regulators of cell growth and the interferon system. Mol. Cell. Biol. 13, 4531\u20134538 (1993).","journal-title":"Mol. Cell. Biol."},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.170.11.5739"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1098\/rsob.120061"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth865"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-21998-3"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkv007"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature11247"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkp335"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1101\/gr.097857.109"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1101\/gr.1933104"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature13182"}],"container-title":["Science Signaling"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/scisignal.aax4917","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,16]],"date-time":"2024-01-16T12:44:07Z","timestamp":1705409047000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/scisignal.aax4917"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5,21]]},"references-count":43,"journal-issue":{"issue":"582","published-print":{"date-parts":[[2019,5,21]]}},"alternative-id":["10.1126\/scisignal.aax4917"],"URL":"https:\/\/doi.org\/10.1126\/scisignal.aax4917","relation":{},"ISSN":["1945-0877","1937-9145"],"issn-type":[{"value":"1945-0877","type":"print"},{"value":"1937-9145","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,5,21]]},"article-number":"eaax4917"}}