{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T08:49:14Z","timestamp":1790844554233,"version":"4.1.0"},"reference-count":56,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"637","funder":[{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R01HL091905"],"award-info":[{"award-number":["R01HL091905"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R01HL137852"],"award-info":[{"award-number":["R01HL137852"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R01HL139585"],"award-info":[{"award-number":["R01HL139585"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R01HL146054"],"award-info":[{"award-number":["R01HL146054"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R01HL122770"],"award-info":[{"award-number":["R01HL122770"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["P20GM130459"],"award-info":[{"award-number":["P20GM130459"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["P20GM103440"],"award-info":[{"award-number":["P20GM103440"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["P30GM110767"],"award-info":[{"award-number":["P30GM110767"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["P01DK041315"],"award-info":[{"award-number":["P01DK041315"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["RFNS110044"],"award-info":[{"award-number":["RFNS110044"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["R61NS115132"],"award-info":[{"award-number":["R61NS115132"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sci. Signal."],"published-print":{"date-parts":[[2020,6,23]]},"abstract":"<jats:p>\n            Ca\n            <jats:sup>2+<\/jats:sup>\n            sparks that control arterial contractility and blood pressure require the lysosomal channel TRPML1.\n          <\/jats:p>","DOI":"10.1126\/scisignal.aba1015","type":"journal-article","created":{"date-parts":[[2020,6,23]],"date-time":"2020-06-23T23:19:41Z","timestamp":1592954381000},"source":"Crossref","is-referenced-by-count":41,"title":["TRPML1 channels initiate Ca\n            <sup>2+<\/sup>\n            sparks in vascular smooth muscle cells"],"prefix":"10.1126","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2086-5453","authenticated-orcid":true,"given":"Pratish","family":"Thakore","sequence":"first","affiliation":[{"name":"Department of Pharmacology, Center for Molecular and Cellular Signaling in the Cardiovascular System, University of Nevada, Reno School of Medicine, Reno, NV 89557-0318, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2408-0909","authenticated-orcid":true,"given":"Harry A. T.","family":"Pritchard","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Center for Molecular and Cellular Signaling in the Cardiovascular System, University of Nevada, Reno School of Medicine, Reno, NV 89557-0318, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7388-4159","authenticated-orcid":true,"given":"Caoimhin S.","family":"Griffin","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Center for Molecular and Cellular Signaling in the Cardiovascular System, University of Nevada, Reno School of Medicine, Reno, NV 89557-0318, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9052-039X","authenticated-orcid":true,"given":"Evan","family":"Yamasaki","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Center for Molecular and Cellular Signaling in the Cardiovascular System, University of Nevada, Reno School of Medicine, Reno, NV 89557-0318, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4762-844X","authenticated-orcid":true,"given":"Bernard T.","family":"Drumm","sequence":"additional","affiliation":[{"name":"Department of Physiology and Cell Biology, University of Nevada, Reno School of Medicine, Reno, NV 89557-0318, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8967-9643","authenticated-orcid":true,"given":"Conor","family":"Lane","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Center for Molecular and Cellular Signaling in the Cardiovascular System, University of Nevada, Reno School of Medicine, Reno, NV 89557-0318, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenton M.","family":"Sanders","sequence":"additional","affiliation":[{"name":"Department of Physiology and Cell Biology, University of Nevada, Reno School of Medicine, Reno, NV 89557-0318, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4138-0105","authenticated-orcid":true,"given":"Yumei","family":"Feng Earley","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Center for Molecular and Cellular Signaling in the Cardiovascular System, University of Nevada, Reno School of Medicine, Reno, NV 89557-0318, USA."},{"name":"Department of Physiology and Cell Biology, University of Nevada, Reno School of Medicine, Reno, NV 89557-0318, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9560-2941","authenticated-orcid":true,"given":"Scott","family":"Earley","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Center for Molecular and Cellular Signaling in the Cardiovascular System, University of Nevada, Reno School of Medicine, Reno, NV 89557-0318, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceca.2014.10.008"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/9.17.2471"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/79095"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellimm.2005.07.001"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00424-009-0716-5"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0709096104"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature07311"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms1037"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2009.12.056"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddn174"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms12109"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2008.09.041"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7793.1998.199br.x"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.270.5236.633"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7793.1998.211br.x"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.115.3.599"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1152\/physiolgenomics.00054.2002"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1113\/JP274310"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(88)80026-6"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.1257"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpj.2010.08.012"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1021\/nl1027638"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2014.079"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1085\/jgp.201611709"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1804593115"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature24036"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0086847"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms5681"},{"key":"e_1_3_2_30_2","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1124\/jpet.108.139295","article-title":"N-((1S)-1-{[4-((2S)-2-{[(2,4-dichlorophenyl)sulfonyl]amino}-3-hydroxypropanoyl)-1-piperazinyl]carbonyl}-3-methylbutyl)-1-benzothiophene-2-carboxamide (GSK1016790A), a novel and potent transient receptor potential vanilloid 4 channel agonist induces urinary bladder contraction and hyperactivity: Part I","volume":"326","author":"Thorneloe K. S.","year":"2008","unstructured":"K. S. Thorneloe, A. C. Sulpizio, Z. Lin, D. Figueroa, A. K. Clouse, G. McCafferty, T. P. Chendrimada, E. S. Lashinger, E. Gordon, L. Evans, B. A. Misajet, D. J. Demarini, J. H. Nation, L. N. Casillas, R. W. Marquis, B. J. Votta, S. A. Sheardown, X. Xu, D. P. Brooks, N. J. Laping, T. D. Westfall, N-((1S)-1-{[4-((2S)-2-{[(2,4-dichlorophenyl)sulfonyl]amino}-3-hydroxypropanoyl)-1-piperazinyl]carbonyl}-3-methylbutyl)-1-benzothiophene-2-carboxamide (GSK1016790A), a novel and potent transient receptor potential vanilloid 4 channel agonist induces urinary bladder contraction and hyperactivity: Part I. J. Pharmacol. Exp. Ther. 326, 432\u2013442 (2008).","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000194321.60300.d6"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1085\/jgp.201311050"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.113.02041"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jhh.1000676"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1038\/35038011"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.87.11.e53"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/0896-6273(95)90321-6"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000100068.43006.36"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI200318684"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI200420347"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2008.09.001"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20150219"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201603081"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms1735"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000155951.62152.2e"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(74)80671-2"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.1111\/jnc.14462"},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00318.2009"},{"key":"e_1_3_2_49_2","doi-asserted-by":"publisher","DOI":"10.1086\/521954"},{"key":"e_1_3_2_50_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02179146"},{"key":"e_1_3_2_51_2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2013.267989"},{"key":"e_1_3_2_52_2","doi-asserted-by":"publisher","DOI":"10.1006\/meth.2001.1262"},{"key":"e_1_3_2_53_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00101.2010"},{"key":"e_1_3_2_54_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymeth.2016.09.016"},{"key":"e_1_3_2_55_2","doi-asserted-by":"publisher","DOI":"10.1186\/gb-2006-7-10-r100"},{"key":"e_1_3_2_56_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2818.2003.01239.x"},{"key":"e_1_3_2_57_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2818.2006.01706.x"}],"container-title":["Science Signaling"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1126\/scisignal.aba1015","content-type":"unspecified","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/scisignal.aba1015","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,16]],"date-time":"2024-01-16T12:10:24Z","timestamp":1705407024000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/scisignal.aba1015"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6,23]]},"references-count":56,"journal-issue":{"issue":"637","published-print":{"date-parts":[[2020,6,23]]}},"alternative-id":["10.1126\/scisignal.aba1015"],"URL":"https:\/\/doi.org\/10.1126\/scisignal.aba1015","relation":{},"ISSN":["1945-0877","1937-9145"],"issn-type":[{"value":"1945-0877","type":"print"},{"value":"1937-9145","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,6,23]]},"article-number":"eaba1015"}}