{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T02:39:34Z","timestamp":1769827174083,"version":"3.49.0"},"reference-count":67,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"730","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sci. Signal."],"published-print":{"date-parts":[[2022,4,19]]},"abstract":"<jats:p>\n            Increased production of reactive oxygen species plays an essential role in the pathogenesis of several diseases, including cardiac hypertrophy. In our search to identify redox-sensitive targets that contribute to redox signaling, we found that protein tyrosine phosphatase 1B (PTP1B) was reversibly oxidized and inactivated in hearts undergoing hypertrophy. Cardiomyocyte-specific deletion of PTP1B in mice (PTP1B cKO mice) caused a hypertrophic phenotype that was exacerbated by pressure overload. Furthermore, we showed that argonaute 2 (AGO2), a key component of the RNA-induced silencing complex, was a substrate of PTP1B in cardiomyocytes and in the heart. Our results revealed that phosphorylation at Tyr\n            <jats:sup>393<\/jats:sup>\n            and inactivation of AGO2 in PTP1B cKO mice prevented miR-208b\u2013mediated repression of thyroid hormone receptor\u2013associated protein 1 (THRAP1; also known as MED13) and contributed to thyroid hormone\u2013mediated cardiac hypertrophy. In support of this conclusion, inhibiting the synthesis of triiodothyronine (T3) with propylthiouracil rescued pressure overload\u2013induced hypertrophy and improved myocardial contractility and systolic function in PTP1B cKO mice. Together, our data illustrate that PTP1B activity is cardioprotective and that redox signaling is linked to thyroid hormone responsiveness and microRNA-mediated gene silencing in pathological hypertrophy.\n          <\/jats:p>","DOI":"10.1126\/scisignal.abn6875","type":"journal-article","created":{"date-parts":[[2022,4,19]],"date-time":"2022-04-19T17:54:21Z","timestamp":1650390861000},"source":"Crossref","is-referenced-by-count":13,"title":["Protein tyrosine phosphatase 1B regulates miR-208b-argonaute 2 association and thyroid hormone responsiveness in cardiac hypertrophy"],"prefix":"10.1126","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5991-9706","authenticated-orcid":true,"given":"G\u00e9rald","family":"Coulis","sequence":"first","affiliation":[{"name":"Department of Nanobioscience, College of Nanoscale Science and Engineering, SUNY Polytechnic Institute, Albany, NY 12203, USA."},{"name":"Montreal Heart Institute, Montreal, QC H1T 1C8, Canada."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6812-4796","authenticated-orcid":true,"given":"Avinash D.","family":"Londhe","sequence":"additional","affiliation":[{"name":"Department of Nanobioscience, College of Nanoscale Science and Engineering, SUNY Polytechnic Institute, Albany, NY 12203, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3897-9480","authenticated-orcid":true,"given":"R. Sudheer","family":"Sagabala","sequence":"additional","affiliation":[{"name":"Department of Nanobioscience, College of Nanoscale Science and Engineering, SUNY Polytechnic Institute, Albany, NY 12203, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanfen","family":"Shi","sequence":"additional","affiliation":[{"name":"Montreal Heart Institute, Montreal, QC H1T 1C8, Canada."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8864-8765","authenticated-orcid":true,"given":"David P.","family":"Labb\u00e9","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Experimental Medicine, McGill University, Montreal, QC H3G 1Y6, Canada."},{"name":"Rosalind and Morris Goodman Cancer Research Centre, McGill University, Montreal, QC H3A 1A3, Canada."},{"name":"Department of Surgery, Division of Urology, McGill University, Montreal, QC H3G 1Y6, Canada."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandre","family":"Bergeron","sequence":"additional","affiliation":[{"name":"Montreal Heart Institute, Montreal, QC H1T 1C8, Canada."},{"name":"Department of Medicine, Universit\u00e9 de Montr\u00e9al, Montreal, QC H3T 1J4, Canada."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pramod","family":"Sahadevan","sequence":"additional","affiliation":[{"name":"Montreal Heart Institute, Montreal, QC H1T 1C8, Canada."},{"name":"Department of Biochemistry and Molecular Medicine, Universit\u00e9 de Montr\u00e9al, Montr\u00e9al, QC H3C 3J7, Canada."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sherin A.","family":"Nawaito","sequence":"additional","affiliation":[{"name":"Montreal Heart Institute, Montreal, QC H1T 1C8, Canada."},{"name":"Pharmacology and Physiology, Universit\u00e9 de Montr\u00e9al, Montr\u00e9al, QC H3C 3J7, Canada."},{"name":"Department of Physiology, Faculty of Medicine, Suez Canal University, Ismailia, Egypt."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fatiha","family":"Sahmi","sequence":"additional","affiliation":[{"name":"Montreal Heart Institute, Montreal, QC H1T 1C8, Canada."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6197-3813","authenticated-orcid":true,"given":"Marie","family":"Josse","sequence":"additional","affiliation":[{"name":"Department of Nanobioscience, College of Nanoscale Science and Engineering, SUNY Polytechnic Institute, Albany, NY 12203, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Val\u00e9rie","family":"Vinette","sequence":"additional","affiliation":[{"name":"Rosalind and Morris Goodman Cancer Research Centre, McGill University, Montreal, QC H3A 1A3, Canada."},{"name":"Department of Biochemistry, McGill University, Montreal, QC H3G 1Y6, Canada."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie-Claude","family":"Guertin","sequence":"additional","affiliation":[{"name":"Montreal Health Innovations Coordinating Center, Montreal, QC H1T 1C8, Canada."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9253-7627","authenticated-orcid":true,"given":"G\u00e9rard","family":"Karsenty","sequence":"additional","affiliation":[{"name":"Department of Genetics and Development, Columbia University, New York, NY 10032, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0281-541X","authenticated-orcid":true,"given":"Michel L.","family":"Tremblay","sequence":"additional","affiliation":[{"name":"Rosalind and Morris Goodman Cancer Research Centre, McGill University, Montreal, QC H3A 1A3, Canada."},{"name":"Department of Biochemistry, McGill University, Montreal, QC H3G 1Y6, Canada."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8200-8983","authenticated-orcid":true,"given":"Jean-Claude","family":"Tardif","sequence":"additional","affiliation":[{"name":"Montreal Heart Institute, Montreal, QC H1T 1C8, Canada."},{"name":"Department of Medicine, Universit\u00e9 de Montr\u00e9al, Montreal, QC H3T 1J4, Canada."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruce G.","family":"Allen","sequence":"additional","affiliation":[{"name":"Montreal Heart Institute, Montreal, QC H1T 1C8, Canada."},{"name":"Department of Medicine, Universit\u00e9 de Montr\u00e9al, Montreal, QC H3T 1J4, Canada."},{"name":"Department of Biochemistry and Molecular Medicine, Universit\u00e9 de Montr\u00e9al, Montr\u00e9al, QC H3C 3J7, Canada."},{"name":"Pharmacology and Physiology, Universit\u00e9 de Montr\u00e9al, Montr\u00e9al, QC H3C 3J7, Canada."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3306-5970","authenticated-orcid":true,"given":"Benoit","family":"Boivin","sequence":"additional","affiliation":[{"name":"Department of Nanobioscience, College of Nanoscale Science and Engineering, SUNY Polytechnic Institute, Albany, NY 12203, USA."},{"name":"Montreal Heart Institute, Montreal, QC H1T 1C8, Canada."},{"name":"Department of Medicine, Universit\u00e9 de Montr\u00e9al, Montreal, QC H3T 1J4, Canada."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"221","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.111.255216"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.116.303584"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2018.01.024"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.110.232306"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2010.12.044"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.109.130351"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1096\/fj.05-3718com"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-06533-2"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1130481"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2008.03.011"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrm3801"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrm2039"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1093\/jb\/mvr104"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2016.08.018"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1042\/CS20160766"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10741-018-9676-1"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vph.2018.05.011"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.283.5407.1544"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.20.15.5479-5489.2000"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.2337\/db08-0913"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.00959-07"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0032700"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.06279-11"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2014.07.018"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2011.08.036"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-017-02252-2"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000215985.18538.c4"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrm1983"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2010.04.005"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1085\/jgp.50.6.197"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.2000.278.2.H412"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2004.09.044"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2007.07.045"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.111.247437"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13578-017-0141-y"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.4161\/23723556.2014.975633"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1102513"},{"key":"e_1_3_3_39_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature09783"},{"key":"e_1_3_3_40_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature12080"},{"key":"e_1_3_3_41_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.94.5.1680"},{"key":"e_1_3_3_42_2","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-15-1501"},{"key":"e_1_3_3_43_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkx1067"},{"key":"e_1_3_3_44_2","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.05005"},{"key":"e_1_3_3_45_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1139089"},{"key":"e_1_3_3_46_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI36154"},{"key":"e_1_3_3_47_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng1963"},{"key":"e_1_3_3_48_2","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-06-4610"},{"key":"e_1_3_3_49_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2016.09.002"},{"key":"e_1_3_3_50_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2009.10.013"},{"key":"e_1_3_3_51_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.embor.7400070"},{"key":"e_1_3_3_52_2","doi-asserted-by":"publisher","DOI":"10.1038\/nsmb.1673"},{"key":"e_1_3_3_53_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.64.5.937"},{"key":"e_1_3_3_54_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0607700103"},{"key":"e_1_3_3_55_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.111.243410"},{"key":"e_1_3_3_56_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.86.4.386"},{"key":"e_1_3_3_57_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.50.4.491"},{"key":"e_1_3_3_58_2","doi-asserted-by":"publisher","DOI":"10.2144\/00291bm09"},{"key":"e_1_3_3_59_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkp112"},{"key":"e_1_3_3_60_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.88.18.8277"},{"key":"e_1_3_3_61_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00238.2001"},{"key":"e_1_3_3_62_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2009.02.025"},{"key":"e_1_3_3_63_2","doi-asserted-by":"publisher","DOI":"10.1006\/jmcc.2000.1150"},{"key":"e_1_3_3_64_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2019.05.014"},{"key":"e_1_3_3_65_2","doi-asserted-by":"publisher","DOI":"10.1021\/pr700801p"},{"key":"e_1_3_3_66_2","doi-asserted-by":"publisher","DOI":"10.1002\/cpch.84"},{"key":"e_1_3_3_67_2","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(76)90527-3"},{"key":"e_1_3_3_68_2","first-page":"413","article-title":"Validation of a multiplex reverse transcription and pre-amplification method using TaqMan microRNA assays","volume":"5","author":"Le Carr\u00e9 J.","year":"2014","unstructured":"J. Le Carr\u00e9, S. Lamon, B. L\u00e9ger, Validation of a multiplex reverse transcription and pre-amplification method using TaqMan microRNA assays. Front. Genet. 5, 413 (2014).","journal-title":"Front. Genet."}],"container-title":["Science Signaling"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/scisignal.abn6875","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,16]],"date-time":"2024-01-16T12:22:39Z","timestamp":1705407759000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/scisignal.abn6875"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4,19]]},"references-count":67,"journal-issue":{"issue":"730","published-print":{"date-parts":[[2022,4,19]]}},"alternative-id":["10.1126\/scisignal.abn6875"],"URL":"https:\/\/doi.org\/10.1126\/scisignal.abn6875","relation":{},"ISSN":["1945-0877","1937-9145"],"issn-type":[{"value":"1945-0877","type":"print"},{"value":"1937-9145","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,4,19]]},"article-number":"eabn6875"}}