{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T03:02:47Z","timestamp":1791428567531,"version":"4.3.3"},"reference-count":122,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"793","content-domain":{"domain":["www.science.org"],"crossmark-restriction":true},"short-container-title":["Sci. Signal."],"published-print":{"date-parts":[[2023,7,11]]},"abstract":"<jats:p>\n                    Uncontrolled inflammation is linked to poor outcomes in sepsis and wound healing, both of which proceed through distinct inflammatory and resolution phases. Eicosanoids are a class of bioactive lipids that recruit neutrophils and other innate immune cells. The interaction of ceramide 1-phosphate (C1P) with the eicosanoid biosynthetic enzyme cytosolic phospholipase A\n                    <jats:sub>2<\/jats:sub>\n                    (cPLA\n                    <jats:sub>2<\/jats:sub>\n                    ) reduces the production of a subtype of eicosanoids called oxoeicosanoids. We investigated the effect of shifting the balance in eicosanoid biosynthesis on neutrophil polarization and function. Knockin mice expressing a cPLA\n                    <jats:sub>2<\/jats:sub>\n                    mutant lacking the C1P binding site (\n                    <jats:italic>\n                      cPLA\n                      <jats:sub>2<\/jats:sub>\n                    <\/jats:italic>\n                    \u03b1\n                    <jats:italic>\n                      <jats:sup>KI\/KI<\/jats:sup>\n                    <\/jats:italic>\n                    mice) showed enhanced and sustained neutrophil infiltration into wounds and the peritoneum during the inflammatory phase of wound healing and sepsis, respectively. The mice exhibited improved wound healing and reduced susceptibility to sepsis, which was associated with an increase in anti-inflammatory N2-type neutrophils demonstrating proresolution behaviors and a decrease in proinflammatory N1-type neutrophils. The N2 polarization of\n                    <jats:italic>\n                      cPLA\n                      <jats:sub>2<\/jats:sub>\n                    <\/jats:italic>\n                    \u03b1\n                    <jats:italic>\n                      <jats:sup>KI\/KI<\/jats:sup>\n                    <\/jats:italic>\n                    neutrophils resulted from increased oxoeicosanoid biosynthesis and autocrine signaling through the oxoeicosanoid receptor OXER1 and partially depended on OXER1-dependent inhibition of the pentose phosphate pathway (PPP). Thus, C1P binding to cPLA\n                    <jats:sub>2<\/jats:sub>\n                    \u03b1 suppresses neutrophil N2 polarization, thereby impairing wound healing and the response to sepsis.\n                  <\/jats:p>","DOI":"10.1126\/scisignal.add6527","type":"journal-article","created":{"date-parts":[[2023,7,11]],"date-time":"2023-07-11T13:58:21Z","timestamp":1689083901000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":21,"title":["Skewing cPLA\n                    <sub>2<\/sub>\n                    \u03b1 activity toward oxoeicosanoid production promotes neutrophil N2 polarization, wound healing, and the response to sepsis"],"prefix":"10.1126","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2868-2934","authenticated-orcid":true,"given":"Kenneth D.","family":"Maus","sequence":"first","affiliation":[{"name":"Department of Cell Biology, Microbiology, and Molecular Biology, University of South Florida, Tampa, FL 33620, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5698-3400","authenticated-orcid":true,"given":"Daniel J.","family":"Stephenson","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Hematology and Oncology, University of Virginia, Charlottesville, VA 22903, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3232-6155","authenticated-orcid":true,"given":"H. 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