{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T11:17:00Z","timestamp":1789471020792,"version":"build-2803163510"},"reference-count":47,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"859","content-domain":{"domain":["www.science.org"],"crossmark-restriction":true},"short-container-title":["Sci. Signal."],"published-print":{"date-parts":[[2024,10,22]]},"abstract":"<jats:p>\n                    Ghrelin is an orexigenic peptide released by gastric ghrelin cells that contributes to obesity and hepatic steatosis. The mechanosensitive ion channel Piezo1 in gastric ghrelin cells inhibits the synthesis and secretion of ghrelin in response to gastric mechanical stretch. We sought to modulate hepatic lipid metabolism by manipulating Piezo1 in gastric ghrelin cells. Mice with a ghrelin cell\u2013specific deficiency of\n                    <jats:italic>Piezo1<\/jats:italic>\n                    (\n                    <jats:italic>\n                      Ghrl-Piezo1\n                      <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    <\/jats:italic>\n                    ) had hyperghrelinemia and hepatic steatosis when fed a low-fat or high-fat diet. In these mice, hepatic lipid accumulation was associated with changes in gene expression and in protein abundance and activity expected to increase hepatic fatty acid synthesis and decrease lipid \u03b2-oxidation. Pharmacological inhibition of the ghrelin receptor improved hepatic steatosis in\n                    <jats:italic>\n                      Ghrl-Piezo1\n                      <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    <\/jats:italic>\n                    mice, thus confirming that the phenotype of these mice was due to overproduction of ghrelin caused by inactivation of Piezo1. Gastric implantation of silicone beads to induce mechanical stretch of the stomach inhibited ghrelin synthesis and secretion, thereby helping to suppress fatty liver development induced by a high-fat diet in wild-type mice but not in\n                    <jats:italic>\n                      Ghrl-Piezo1\n                      <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    <\/jats:italic>\n                    mice. Our study elucidates the mechanism by which Piezo1 in gastric ghrelin cells regulate hepatic lipid accumulation, providing insights into potential treatments for fatty liver.\n                  <\/jats:p>","DOI":"10.1126\/scisignal.adq9463","type":"journal-article","created":{"date-parts":[[2024,10,22]],"date-time":"2024-10-22T13:58:08Z","timestamp":1729605488000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":9,"title":["Mechanosensing by Piezo1 in gastric ghrelin cells contributes to hepatic lipid homeostasis in mice"],"prefix":"10.1126","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-2201-9476","authenticated-orcid":true,"given":"Jinshan","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Physiology, School of Medicine, Jinan University, 601 Huangpu Avenue West, Tianhe District, Guangzhou, Guangdong 510632, China."},{"name":"Department of Metabolic and Bariatric Surgery, First Affiliated Hospital of Jinan University, 613 Huangpu Avenue West, Tianhe District, Guangzhou, Guangdong 510630, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yawen","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Physiology, School of Medicine, Jinan University, 601 Huangpu Avenue West, Tianhe District, Guangzhou, Guangdong 510632, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaohong","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Physiology, School of Medicine, Jinan University, 601 Huangpu Avenue West, Tianhe District, Guangzhou, Guangdong 510632, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengxue","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Physiology, School of Medicine, Jinan University, 601 Huangpu Avenue West, Tianhe District, Guangzhou, Guangdong 510632, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luyang","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Physiology, School of Medicine, Jinan University, 601 Huangpu Avenue West, Tianhe District, Guangzhou, Guangdong 510632, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ke","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Physiology, School of Medicine, Jinan University, 601 Huangpu Avenue West, Tianhe District, Guangzhou, Guangdong 510632, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Chen","sequence":"additional","affiliation":[{"name":"Biotherapy Center; 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