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Oncogenic tyrosine kinase signaling in leukemia cells stimulated NF-\u03baB\u2013mediated\n                    <jats:italic toggle=\"yes\">CD25<\/jats:italic>\n                    expression, whereas PKC\u03b4-mediated phosphorylation of CD25 suppressed oncogenic tyrosine kinase signaling through inhibitory phosphatases, such as PTPN6. Interactome analyses and mass spectrometry\u2013based global phosphoproteomic analyses showed that\n                    <jats:italic toggle=\"yes\">CD25<\/jats:italic>\n                    deletion abolished the phosphatase activity of PTPN6, resulting in enhanced activation of tyrosine kinases and NF-\u03baB. Four injections of a CD25 antibody-drug conjugate induced complete remission in mice transplanted with PDX refractory leukemia. These findings highlight the dependency of tyrosine kinase\u2013driven leukemias on robust feedback control and the role of PKC\u03b4 and CD25 in assembling its components.\n                  <\/jats:p>","DOI":"10.1126\/scisignal.adw5054","type":"journal-article","created":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T18:58:21Z","timestamp":1770749901000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":0,"title":["Dynamic feedback control of oncogenic tyrosine kinase signaling in acute leukemia"],"prefix":"10.1126","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7952-5544","authenticated-orcid":true,"given":"Jaewoong","family":"Lee","sequence":"first","affiliation":[{"name":"Center of Molecular and Cellular Oncology, Yale University, New Haven, CT 06511, USA."},{"name":"Department of Immunobiology, Yale University, New Haven, CT 06511, USA."},{"name":"School of Biosystems and Biomedical Sciences, College 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