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Signal."],"published-print":{"date-parts":[[2026,10,20]]},"abstract":"<jats:p>\n                    Brain vasculature is essential for central nervous system function. Here, we found a cerebrovascular signaling axis in which the arginine methyltransferase PRMT5 in endothelial cells promoted proper inhibitory synaptogenesis and motor coordination in male mice. Cerebrovascular endothelial cell\u2013specific deletion of\n                    <jats:italic toggle=\"yes\">Prmt5<\/jats:italic>\n                    in mice led to excessive inhibitory synaptic input onto Purkinje cells and progressive motor deficits. Mechanistically,\n                    <jats:italic toggle=\"yes\">Prmt5<\/jats:italic>\n                    deficiency epigenetically increased the expression of the gene encoding the secreted angiocrine ANGPTL4 through reduced symmetric dimethylation of Arg\n                    <jats:sup>8<\/jats:sup>\n                    in histone H3 and Arg\n                    <jats:sup>3<\/jats:sup>\n                    in histone H4, which coincided with increased acetylation of Lys\n                    <jats:sup>9<\/jats:sup>\n                    in histone H3, at the\n                    <jats:italic toggle=\"yes\">Angptl4<\/jats:italic>\n                    promoter.\n                    <jats:italic toggle=\"yes\">Angptl4<\/jats:italic>\n                    deletion in brain endothelium normalized inhibitory synaptic input onto Purkinje cells and partially restored motor coordination in mice with a conditional\n                    <jats:italic toggle=\"yes\">Prmt5<\/jats:italic>\n                    deficiency. Together, these findings define the endothelial PRMT5-ANGPTL4 axis as a key regulator of cerebellar inhibitory circuitry and motor function, highlighting cerebrovascular mechanisms as potential therapeutic targets for motor coordination disorders.\n                  <\/jats:p>","DOI":"10.1126\/scisignal.aed6605","type":"journal-article","created":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T17:58:22Z","timestamp":1792519102000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":0,"title":["A PRMT5-ANGPTL4 axis in brain endothelial cells regulates cerebellar inhibitory synaptogenesis and motor coordination"],"prefix":"10.1126","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-6769-1067","authenticated-orcid":true,"given":"Jinjin","family":"Lu","sequence":"first","affiliation":[{"name":"State Key Laboratory of Medical Proteomics, National Center for Protein Sciences (Beijing), Beijing 102206, 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