{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T05:56:55Z","timestamp":1788328615862,"version":"build-2803163510"},"reference-count":49,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"953","funder":[{"DOI":"10.13039\/100000050","name":"NHLBI","doi-asserted-by":"crossref","award":["R35HL155008"],"award-info":[{"award-number":["R35HL155008"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000050","name":"NHLBI","doi-asserted-by":"crossref","award":["R35HL150778"],"award-info":[{"award-number":["R35HL150778"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["www.science.org"],"crossmark-restriction":true},"short-container-title":["Sci. Signal."],"published-print":{"date-parts":[[2026,9,1]]},"abstract":"<jats:p>\n                    Neurovascular coupling (NVC), which is initiated by the brain\u2019s dense capillary network, matches blood flow to neuronal activity. We found that ORAI1 channels and their regulator STIM1, the main drivers of store-operated Ca\n                    <jats:sup>2+<\/jats:sup>\n                    entry, were essential for communication from capillaries, which detect neuronal metabolic need, to upstream arterioles, which dilate to increase regional flow. Endothelial cell\u2013specific knockout of either\n                    <jats:italic toggle=\"yes\">Stim1<\/jats:italic>\n                    or\n                    <jats:italic toggle=\"yes\">Orai1<\/jats:italic>\n                    disrupted capillary Ca\n                    <jats:sup>2+<\/jats:sup>\n                    signals, impaired sustained capillary-driven arteriole dilation, and reduced increases in blood flow in the somatosensory cortex evoked by whisker stimulation, indicating that ORAI1 and STIM1 sustain cerebral blood flow during prolonged neuronal stimulation. Moreover, mice with endothelial cell\u2013specific deficiency of\n                    <jats:italic toggle=\"yes\">Stim1<\/jats:italic>\n                    or\n                    <jats:italic toggle=\"yes\">Orai1<\/jats:italic>\n                    showed cognitive impairment, whereas mice with endothelial cell\u2013specific deficiency of\n                    <jats:italic toggle=\"yes\">Orai3<\/jats:italic>\n                    showed anxiety-like behaviors. These in vivo results link impaired capillary-to-arteriole signaling to isoform-specific behavioral aberrations. These findings demonstrate that intravascular communication mediated by ORAI channels and STIM1 is fundamental for NVC and brain health.\n                  <\/jats:p>","DOI":"10.1126\/scisignal.aef0939","type":"journal-article","created":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T17:58:28Z","timestamp":1788285508000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":1,"title":["ORAI Ca\n                    <sup>2+<\/sup>\n                    channels and STIM1 drive capillary-to-arteriole communication in neurovascular coupling"],"prefix":"10.1126","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6827-7095","authenticated-orcid":true,"given":"Boris","family":"Lavanderos","sequence":"first","affiliation":[{"name":"Department of Pharmacology and Physiology, University of Rochester Medical Center, Rochester, NY 14642, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8218-256X","authenticated-orcid":true,"given":"Alfredo","family":"Sanchez-Solano","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Physiology, University of Rochester Medical Center, Rochester, NY 14642, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0313-2119","authenticated-orcid":true,"given":"Wanchun","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Physiology, University of Rochester Medical Center, Rochester, NY 14642, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2086-5453","authenticated-orcid":true,"given":"Pratish","family":"Thakore","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, University of Nevada, Reno, Reno, NV 89557, 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