{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T18:44:39Z","timestamp":1776797079045,"version":"3.51.2"},"reference-count":8,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"934","content-domain":{"domain":["www.science.org"],"crossmark-restriction":true},"short-container-title":["Sci. Signal."],"published-print":{"date-parts":[[2026,4,21]]},"abstract":"<jats:p>\n                    Ca\n                    <jats:sup>2+<\/jats:sup>\n                    flux is a key trigger of NLRP3 inflammasome activation, but bone-resorbing osteoclasts operate in a Ca\n                    <jats:sup>2+<\/jats:sup>\n                    -rich environment created during bone resorption. In this issue of\n                    <jats:italic toggle=\"yes\">Science Signaling<\/jats:italic>\n                    , Kaur\n                    <jats:italic toggle=\"yes\">et\u00a0al.<\/jats:italic>\n                    reveal that osteoclasts prevent inflammasome activation by limiting Ca\n                    <jats:sup>2+<\/jats:sup>\n                    influx through the membrane protein Tmem178, thereby protecting bone from excessive resorption driven by inflammatory signaling.\n                  <\/jats:p>","DOI":"10.1126\/scisignal.aeg1707","type":"journal-article","created":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T17:58:12Z","timestamp":1776794292000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":0,"title":["Keeping inflammasomes in check during bone resorption"],"prefix":"10.1126","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7717-7272","authenticated-orcid":true,"given":"Caroline","family":"Schmidt","sequence":"first","affiliation":[{"name":"Division of Rheumatology, Department of Endocrinology, Nephrology, Rheumatology, Leipzig University, Leipzig, Germany."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8106-4924","authenticated-orcid":true,"given":"Ulf","family":"Wagner","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Department of Endocrinology, Nephrology, Rheumatology, Leipzig University, Leipzig, Germany."},{"name":"LeiCeM - Leipzig Center of Metabolism, Leipzig University, Leipzig, Germany."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"221","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-07014-0"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1097-2765(02)00599-3"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.aea2753"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1117765109"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-17749-6"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41366-022-01135-x"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2021.07.005"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1511285112"}],"container-title":["Science Signaling"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/scisignal.aeg1707","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T17:58:19Z","timestamp":1776794299000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/scisignal.aeg1707"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,21]]},"references-count":8,"journal-issue":{"issue":"934","published-print":{"date-parts":[[2026,4,21]]}},"alternative-id":["10.1126\/scisignal.aeg1707"],"URL":"https:\/\/doi.org\/10.1126\/scisignal.aeg1707","relation":{},"ISSN":["1945-0877","1937-9145"],"issn-type":[{"value":"1945-0877","type":"print"},{"value":"1937-9145","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,21]]},"assertion":[{"value":"2026-03-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-02","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-21","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"eaeg1707"}}