{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T22:24:05Z","timestamp":1792189445220,"version":"4.4.0"},"reference-count":36,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"14","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sci. Transl. Med."],"published-print":{"date-parts":[[2010,1,13]]},"abstract":"<jats:p>Treating monkeys with single doses of an antiretroviral drug before and after exposure to SHIV provides protection against infection, a schedule that may prove practical in humans.<\/jats:p>","DOI":"10.1126\/scitranslmed.3000391","type":"journal-article","created":{"date-parts":[[2010,1,13]],"date-time":"2010-01-13T23:09:37Z","timestamp":1263424177000},"source":"Crossref","is-referenced-by-count":130,"title":["Intermittent Prophylaxis with Oral Truvada Protects Macaques from Rectal SHIV Infection"],"prefix":"10.1126","volume":"2","author":[{"given":"J. Gerardo","family":"Garc\u00eda-Lerma","sequence":"first","affiliation":[{"name":"Division of HIV\/AIDS Prevention, National Center for HIV, Hepatitis, STD, and Prevention, Centers for Disease Control and Prevention, 1600 Clifton Road, Atlanta, GA 30329, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mian-er","family":"Cong","sequence":"additional","affiliation":[{"name":"Division of HIV\/AIDS Prevention, National Center for HIV, Hepatitis, STD, and Prevention, Centers for Disease Control and Prevention, 1600 Clifton Road, Atlanta, GA 30329, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Mitchell","sequence":"additional","affiliation":[{"name":"Division of HIV\/AIDS Prevention, National Center for HIV, Hepatitis, STD, and Prevention, Centers for Disease Control and Prevention, 1600 Clifton Road, Atlanta, GA 30329, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ae S.","family":"Youngpairoj","sequence":"additional","affiliation":[{"name":"Division of HIV\/AIDS Prevention, National Center for HIV, Hepatitis, STD, and Prevention, Centers for Disease Control and Prevention, 1600 Clifton Road, Atlanta, GA 30329, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Zheng","sequence":"additional","affiliation":[{"name":"Division of HIV\/AIDS Prevention, National Center for HIV, Hepatitis, STD, and Prevention, Centers for Disease Control and Prevention, 1600 Clifton Road, Atlanta, GA 30329, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvina","family":"Masciotra","sequence":"additional","affiliation":[{"name":"Division of HIV\/AIDS Prevention, National Center for HIV, Hepatitis, STD, and Prevention, Centers for Disease Control and Prevention, 1600 Clifton Road, Atlanta, GA 30329, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy","family":"Martin","sequence":"additional","affiliation":[{"name":"Division of HIV\/AIDS Prevention, National Center for HIV, Hepatitis, STD, and Prevention, Centers for Disease Control and Prevention, 1600 Clifton Road, Atlanta, GA 30329, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zsuzsanna","family":"Kuklenyik","sequence":"additional","affiliation":[{"name":"Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA 30329, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Holder","sequence":"additional","affiliation":[{"name":"Division of HIV\/AIDS Prevention, National Center for HIV, Hepatitis, STD, and Prevention, Centers for Disease Control and Prevention, 1600 Clifton Road, Atlanta, GA 30329, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Lipscomb","sequence":"additional","affiliation":[{"name":"Division of HIV\/AIDS Prevention, National Center for HIV, Hepatitis, STD, and Prevention, Centers for Disease Control and Prevention, 1600 Clifton Road, Atlanta, GA 30329, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chou-Pong","family":"Pau","sequence":"additional","affiliation":[{"name":"Division of HIV\/AIDS Prevention, National Center for HIV, Hepatitis, STD, and Prevention, Centers for Disease Control and Prevention, 1600 Clifton Road, Atlanta, GA 30329, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John R.","family":"Barr","sequence":"additional","affiliation":[{"name":"Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA 30329, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Debra L.","family":"Hanson","sequence":"additional","affiliation":[{"name":"Division of HIV\/AIDS Prevention, National Center for HIV, Hepatitis, STD, and Prevention, Centers for Disease Control and Prevention, 1600 Clifton Road, Atlanta, GA 30329, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ron","family":"Otten","sequence":"additional","affiliation":[{"name":"Division of HIV\/AIDS Prevention, National Center for HIV, Hepatitis, STD, and Prevention, Centers for Disease Control and Prevention, 1600 Clifton Road, Atlanta, GA 30329, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lynn","family":"Paxton","sequence":"additional","affiliation":[{"name":"Division of HIV\/AIDS Prevention, National Center for HIV, Hepatitis, STD, and Prevention, Centers for Disease Control and Prevention, 1600 Clifton Road, Atlanta, GA 30329, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas M.","family":"Folks","sequence":"additional","affiliation":[{"name":"Division of HIV\/AIDS Prevention, National Center for HIV, Hepatitis, STD, and Prevention, Centers for Disease Control and Prevention, 1600 Clifton Road, Atlanta, GA 30329, USA."},{"name":"Southwest National Primate Research Center, Southwest Foundation for Biomedical Research, San Antonio, TX 78245, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walid","family":"Heneine","sequence":"additional","affiliation":[{"name":"Division of HIV\/AIDS Prevention, National Center for HIV, Hepatitis, STD, and Prevention, Centers for Disease Control and Prevention, 1600 Clifton Road, Atlanta, GA 30329, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","unstructured":"UNAIDS\/WHO Report on the global HIV\/AIDS epidemic 2008 (UNAIDS Geneva 2008); www.unaids.org\/en\/KnowledgeCentre\/HIVData\/GlobalReport\/2008."},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0908492"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)60885-5"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm0209-126"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199711203372101"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0801941"},{"key":"e_1_3_2_8_2","first-page":"CD003510","article-title":"Antiretrovirals for reducing the risk of mother-to-child transmission of HIV infection.","author":"Volmink J.","year":"2007","unstructured":"Volmink J., Siegfried N. L., van der Merwe L., Brocklehurst P., Antiretrovirals for reducing the risk of mother-to-child transmission of HIV infection. Cochrane Database Syst. Rev. CD003510 (2007). http:\/\/www.cochrane.org\/reviews\/en\/ab003510.html.","journal-title":"Cochrane Database Syst. Rev."},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.0050028"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1086\/507306"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.qai.0000224972.60339.7c"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0802203105"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature07831"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.79.14.9217-9227.2005"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0b013e328270385a"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-146-8-200704170-00010"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1086\/426452"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20082831"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.qai.0000167155.44980.e8"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.49.5.1907-1914.2005"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1089\/aid.2004.20.1173"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri1706"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.74.13.6087-6095.2000"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1002\/jlb.56.3.273"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1012108719462"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1086\/517436"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1086\/429411"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a009331"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1086\/510909"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1097\/QAI.0b013e318189a753"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0b013e3283060ea4"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2003.08.021"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.284.5415.816"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1086\/386333"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1089\/aid.2006.22.912"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature04055"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1093\/chromsci\/47.5.365"}],"container-title":["Science Translational Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/scitranslmed.3000391","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,16]],"date-time":"2024-01-16T18:13:24Z","timestamp":1705428804000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/scitranslmed.3000391"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,1,13]]},"references-count":36,"journal-issue":{"issue":"14","published-print":{"date-parts":[[2010,1,13]]}},"alternative-id":["10.1126\/scitranslmed.3000391"],"URL":"https:\/\/doi.org\/10.1126\/scitranslmed.3000391","relation":{},"ISSN":["1946-6234","1946-6242"],"issn-type":[{"value":"1946-6234","type":"print"},{"value":"1946-6242","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,1,13]]}}}