{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T13:12:33Z","timestamp":1792501953139,"version":"4.5.0"},"reference-count":42,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"29","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sci. Transl. Med."],"published-print":{"date-parts":[[2010,4,28]]},"abstract":"<jats:p>The lungs of just-born piglets with cystic fibrosis fail to efficiently eliminate bacteria, suggesting that lung problems in cystic fibrosis patients may be secondary to impaired antibacterial defense mechanisms.<\/jats:p>","DOI":"10.1126\/scitranslmed.3000928","type":"journal-article","created":{"date-parts":[[2010,4,28]],"date-time":"2010-04-28T22:18:51Z","timestamp":1272493131000},"source":"Crossref","is-referenced-by-count":429,"title":["Cystic Fibrosis Pigs Develop Lung Disease and Exhibit Defective Bacterial Eradication at Birth"],"prefix":"10.1126","volume":"2","author":[{"given":"David A.","family":"Stoltz","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David K.","family":"Meyerholz","sequence":"additional","affiliation":[{"name":"Department of Pathology, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandro A.","family":"Pezzulo","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shyam","family":"Ramachandran","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark P.","family":"Rogan","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Greg J.","family":"Davis","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert A.","family":"Hanfland","sequence":"additional","affiliation":[{"name":"Department of Surgery, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chris","family":"Wohlford-Lenane","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cassie L.","family":"Dohrn","sequence":"additional","affiliation":[{"name":"Department of Pathology, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer A.","family":"Bartlett","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"IV","given":"George A.","family":"Nelson","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eugene H.","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter J.","family":"Taft","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula S.","family":"Ludwig","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mira","family":"Estin","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emma E.","family":"Hornick","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janice L.","family":"Launspach","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa","family":"Samuel","sequence":"additional","affiliation":[{"name":"Division of Animal Sciences, University of Missouri, Columbia, MO 65211, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatiana","family":"Rokhlina","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip H.","family":"Karp","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA."},{"name":"Howard Hughes Medical Institute, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lynda S.","family":"Ostedgaard","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aliye","family":"Uc","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy D.","family":"Starner","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander R.","family":"Horswill","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kim A.","family":"Brogden","sequence":"additional","affiliation":[{"name":"Department of Periodontics and Dows Institute for Dental Research, College of Dentistry, University of Iowa, Iowa City, IA 52242, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Randall S.","family":"Prather","sequence":"additional","affiliation":[{"name":"Division of Animal Sciences, University of Missouri, Columbia, MO 65211, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra S.","family":"Richter","sequence":"additional","affiliation":[{"name":"Department of Pathology, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joel","family":"Shilyansky","sequence":"additional","affiliation":[{"name":"Department of Surgery, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr.","given":"Paul B.","family":"McCray","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Zabner","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J.","family":"Welsh","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA."},{"name":"Howard Hughes Medical Institute, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA."},{"name":"Department of Molecular Physiology and Biophysics, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.2475911"},{"key":"e_1_3_2_3_2","unstructured":"M. J. Welsh B. W. Ramsey F. Accurso G. R. Cutting Cystic fibrosis in The Metabolic and Molecular Basis of Inherited Disease C. R. Scriver A. L. Beaudet W. S. Sly D. Valle B. Childs B. Vogelstein Eds. (McGraw-Hill New York 2001) pp. 5121\u20135189."},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.1999.79.1.S3"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra043184"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80570-X"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1186\/1465-9921-4-8"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-981649"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.1999.79.1.S193"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI34773"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1163600"},{"key":"e_1_3_2_12_2","first-page":"303","article-title":"Quantitative evaluation of the development of tracheal submucosal glands in infants with cystic fibrosis and control infants.","volume":"106","author":"Sturgess J.","year":"1982","unstructured":"Sturgess J., Imrie J., Quantitative evaluation of the development of tracheal submucosal glands in infants with cystic fibrosis and control infants. Am. J. Pathol. 106, 303\u2013311 (1982).","journal-title":"Am. J. Pathol."},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(81)80240-7"},{"key":"e_1_3_2_14_2","first-page":"1075","article-title":"Early pulmonary inflammation in infants with cystic fibrosis.","volume":"151","author":"Khan T. Z.","year":"1995","unstructured":"Khan T. Z., Wagener J. S., Bost T., Martinez J., Accurso F. J., Riches D. W., Early pulmonary inflammation in infants with cystic fibrosis. Am. J. Respir. Crit. Care Med. 151, 1075\u20131082 (1995).","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.1950200203"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1099-0496(199812)26:6<371::AID-PPUL1>3.0.CO;2-N"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200206-627OC"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00403.2005"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.2001.281.1.L71"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0402030101"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1165\/ajrcmb.23.2.4214"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-199202000-00014"},{"key":"e_1_3_2_23_2","first-page":"251","article-title":"Hemorrhagic gastroesophageal ulceration by pulmonary infection in extrahepatic cholestatic pigs.","volume":"25","author":"Trobo J. I.","year":"1994","unstructured":"Trobo J. I., Lorente L., Aller M. A., Dur\u00e1n M. C., Betriu C., Arias J., Hemorrhagic gastroesophageal ulceration by pulmonary infection in extrahepatic cholestatic pigs. J. Med. 25, 251\u2013254 (1994).","journal-title":"J. Med."},{"key":"e_1_3_2_24_2","unstructured":"B. E. Straw Diseases of swine (C.H.I.P.S. Texas ed. 9 2006)."},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1001\/archpedi.1938.01980140114013"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2010.090849"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.09-0132"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0709804104"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(76)80023-8"},{"key":"e_1_3_2_30_2","first-page":"94","article-title":"Observations in cystic fibrosis of the pancreas. 3. Pulmonary lesions.","volume":"122","author":"Esterly J. R.","year":"1968","unstructured":"Esterly J. R., Oppenheimer E. H., Observations in cystic fibrosis of the pancreas. 3. Pulmonary lesions. Johns Hopkins Med. J. 122, 94\u2013101 (1968).","journal-title":"Johns Hopkins Med. J."},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.20294"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI34599"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.1144"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1099\/mic.0.2006\/004077-0"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcf.2007.06.006"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/0076-6879(91)04029-N"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI118573"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.10448"},{"key":"e_1_3_2_39_2","unstructured":"Gene Pattern Broad Institute http:\/\/www.broadinstitute.org\/cancer\/software\/genepattern\/."},{"key":"e_1_3_2_40_2","unstructured":"Partek: Turning data into discovery http:\/\/www.partek.com\/."},{"key":"e_1_3_2_41_2","unstructured":"Gene Set Enrichment Analysis http:\/\/www.broadinstitute.org\/gsea\/."},{"key":"e_1_3_2_42_2","unstructured":"Ingenuity Systems http:\/\/www.ingenuity.com\/."},{"key":"e_1_3_2_43_2","unstructured":"DAVID Bioinformatics Resources 6.7 http:\/\/david.abcc.ncifcrf.gov\/."}],"container-title":["Science Translational Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/scitranslmed.3000928","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,16]],"date-time":"2024-01-16T17:31:24Z","timestamp":1705426284000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/scitranslmed.3000928"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,4,28]]},"references-count":42,"journal-issue":{"issue":"29","published-print":{"date-parts":[[2010,4,28]]}},"alternative-id":["10.1126\/scitranslmed.3000928"],"URL":"https:\/\/doi.org\/10.1126\/scitranslmed.3000928","relation":{},"ISSN":["1946-6234","1946-6242"],"issn-type":[{"value":"1946-6234","type":"print"},{"value":"1946-6242","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,4,28]]}}}