{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T16:42:19Z","timestamp":1793464939702,"version":"4.5.0"},"reference-count":42,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"36","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sci. Transl. Med."],"published-print":{"date-parts":[[2010,6,16]]},"abstract":"<jats:p>Transfected stem cells transplanted into patients with HIV infection resulted in sustained RNA expression of introduced genes in blood cells for up to 2 years.<\/jats:p>","DOI":"10.1126\/scitranslmed.3000931","type":"journal-article","created":{"date-parts":[[2010,6,16]],"date-time":"2010-06-16T22:11:39Z","timestamp":1276726299000},"source":"Crossref","is-referenced-by-count":337,"title":["RNA-Based Gene Therapy for HIV with Lentiviral Vector\u2013Modified CD34\n            <sup>+<\/sup>\n            Cells in Patients Undergoing Transplantation for AIDS-Related Lymphoma"],"prefix":"10.1126","volume":"2","author":[{"given":"David L.","family":"DiGiusto","sequence":"first","affiliation":[{"name":"Department of Hematology and Hematopoietic Cell Transplantation, City of Hope, Duarte, CA 91010, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amrita","family":"Krishnan","sequence":"additional","affiliation":[{"name":"Department of Hematology and Hematopoietic Cell Transplantation, City of Hope, Duarte, CA 91010, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lijing","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Hematology and Hematopoietic Cell Transplantation, City of Hope, Duarte, CA 91010, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haitang","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Molecular and Cellular Biology, City of Hope, Duarte, CA 91010, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shirley","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Virology, City of Hope, Duarte, CA 91010, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anitha","family":"Rao","sequence":"additional","affiliation":[{"name":"Department of Hematology and Hematopoietic Cell Transplantation, City of Hope, Duarte, CA 91010, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu","family":"Mi","sequence":"additional","affiliation":[{"name":"Clinical Immunobiology Correlative Studies Laboratory, City of Hope, Duarte, CA 91010, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priscilla","family":"Yam","sequence":"additional","affiliation":[{"name":"Department of Virology, City of Hope, Duarte, CA 91010, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sherri","family":"Stinson","sequence":"additional","affiliation":[{"name":"General Clinical Research Center, City of Hope, Duarte, CA 91010, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Kalos","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Alvarnas","sequence":"additional","affiliation":[{"name":"Department of Hematology and Hematopoietic Cell Transplantation, City of Hope, Duarte, CA 91010, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon F.","family":"Lacey","sequence":"additional","affiliation":[{"name":"Clinical Immunobiology Correlative Studies Laboratory, City of Hope, Duarte, CA 91010, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiing-Kuan","family":"Yee","sequence":"additional","affiliation":[{"name":"Department of Virology, City of Hope, Duarte, CA 91010, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingjie","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Neurology, Washington University School of Medicine, St. Louis, MO 63110, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Larry","family":"Couture","sequence":"additional","affiliation":[{"name":"Department of Virology, City of Hope, Duarte, CA 91010, USA."},{"name":"Center for Applied Technology Development, City of Hope, Duarte, CA 91010, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Hsu","sequence":"additional","affiliation":[{"name":"Center for Applied Technology Development, City of Hope, Duarte, CA 91010, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen J.","family":"Forman","sequence":"additional","affiliation":[{"name":"Department of Hematology and Hematopoietic Cell Transplantation, City of Hope, Duarte, CA 91010, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John J.","family":"Rossi","sequence":"additional","affiliation":[{"name":"Department of Molecular and Cellular Biology, City of Hope, Duarte, CA 91010, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John A.","family":"Zaia","sequence":"additional","affiliation":[{"name":"Department of Virology, City of Hope, Duarte, CA 91010, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1165706"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1086\/500453"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/335395a0"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0802905"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.89.20.9870"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.71.6.4707-4716.1997"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1089\/hum.2007.095"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2005.02.019"},{"key":"e_1_3_2_10_2","first-page":"717","article-title":"Sustained retroviral gene marking and expression in lymphoid and myeloid cells derived from transduced hematopoietic progenitor cells.","volume":"3","author":"Plavec I.","year":"1996","unstructured":"Plavec I., Voytovich A., Moss K., Webster D., Hanley M. B., Escaich S., Ho K. E., B\u00f6hnlein E., DiGiusto D. L., Sustained retroviral gene marking and expression in lymphoid and myeloid cells derived from transduced hematopoietic progenitor cells. Gene Ther. 3, 717\u2013724 (1996).","journal-title":"Gene Ther."},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymthe.2005.05.014"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/jgm.520"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/gt.2008.147"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.mt.6300157"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/jgm.1238"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/nbt1367"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-04-014829"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1038\/mt.sj.6300124"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V99.2.698"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymthe.2005.02.024"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1089\/104303404322886101"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm.1932"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-04-1532"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymthe.2005.10.009"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.gt.3301893"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1038\/mt.2009.16"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V87.11.4618.bloodjournal87114618"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V84.2.421.421"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1525-0016(03)00165-5"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymthe.2005.07.524"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1171242"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.272.5259.263"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.73.5.3649-3660.1999"},{"key":"e_1_3_2_34_2","first-page":"99","article-title":"Production of lentiviruses displaying \u201cearly-acting\u201d cytokines for selective gene transfer into hematopoietic stem cells.","volume":"434","author":"Verhoeyen E.","year":"2008","unstructured":"Verhoeyen E., N\u00e8gre D., Cosset F. L., Production of lentiviruses displaying \u201cearly-acting\u201d cytokines for selective gene transfer into hematopoietic stem cells. Methods Mol. Biol. 434, 99\u2013112 (2008).","journal-title":"Methods Mol. Biol."},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1525-0016(03)00005-4"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymthe.2006.05.015"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1525-0016(03)00140-0"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-06-2335"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-05-1572"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.gt.3301781"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1038\/gt.2009.133"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1006\/mthe.2002.0558"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199309303291402"}],"container-title":["Science Translational Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/scitranslmed.3000931","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,16]],"date-time":"2024-01-16T17:32:11Z","timestamp":1705426331000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/scitranslmed.3000931"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,6,16]]},"references-count":42,"journal-issue":{"issue":"36","published-print":{"date-parts":[[2010,6,16]]}},"alternative-id":["10.1126\/scitranslmed.3000931"],"URL":"https:\/\/doi.org\/10.1126\/scitranslmed.3000931","relation":{},"ISSN":["1946-6234","1946-6242"],"issn-type":[{"value":"1946-6234","type":"print"},{"value":"1946-6242","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,6,16]]}}}