{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T18:04:20Z","timestamp":1760983460520},"reference-count":21,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"23","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sci. Transl. Med."],"published-print":{"date-parts":[[2010,3,17]]},"abstract":"<jats:p>\n            Mutations in the\n            <jats:italic>fibrillin-1<\/jats:italic>\n            gene that cause a rare\ncongenital form of scleroderma called stiff skin syndrome shed light on\na common fibrotic condition, systemic sclerosis.\n          <\/jats:p>","DOI":"10.1126\/scitranslmed.3000949","type":"journal-article","created":{"date-parts":[[2010,3,17]],"date-time":"2010-03-17T22:12:57Z","timestamp":1268863977000},"source":"Crossref","is-referenced-by-count":5,"title":["Stiff and Tight Skin: A Rear Window into Fibrosis Without Inflammation"],"prefix":"10.1126","volume":"2","author":[{"given":"Enrico V.","family":"Avvedimento","sequence":"first","affiliation":[{"name":"Department of Biologia e Patologia Molecolare e Cellulare, Universita Federico II Medical School, Naples, Italy."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Armando","family":"Gabrielli","sequence":"additional","affiliation":[{"name":"Department of Scienze Mediche e Chirurgiche, Sez Clinica Medica, Universita Politecnica delle Marche, Ancona, Italy."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"221","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1176009"},{"key":"e_1_3_1_3_2","first-page":"23ra20","article-title":"Mutations in fibrillin-1 cause congenital scleroderma: Stiff skin syndrome.","volume":"23","author":"Loeys B. L.","year":"2010","unstructured":"Loeys B. L., Gerber E. E., Riegert-Johnson D., Iqbal S., Whiteman P., McConnell V., Chillakuri C. R., Macaya D., Coucke P. J., De Paepe A., Judge D. P., Wigley F., Davis E. C., Mardon H. J., Handford P., Keene D. R., Sakai L. Y., Dietz H. C., Mutations in fibrillin-1 cause congenital scleroderma: Stiff skin syndrome. Science Transl. Med. 23, 23ra20 (2010).","journal-title":"Science Transl. Med."},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrg2520"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra0806188"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1101\/gr.6.4.300"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.str.2009.03.014"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M209256200"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.bor.0000245719.64393.57"},{"key":"e_1_3_1_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11926-009-0017-1"},{"key":"e_1_3_1_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jid.5701101"},{"key":"e_1_3_1_12_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M502851200"},{"key":"e_1_3_1_13_2","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddg081"},{"key":"e_1_3_1_14_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1000691"},{"key":"e_1_3_1_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.21278"},{"key":"e_1_3_1_16_2","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.01199-08"},{"key":"e_1_3_1_17_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M806962200"},{"key":"e_1_3_1_18_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jid.5700786"},{"key":"e_1_3_1_19_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00320.2009"},{"key":"e_1_3_1_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.24221"},{"key":"e_1_3_1_21_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2009.120196"},{"key":"e_1_3_1_22_2","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.109.137885"}],"container-title":["Science Translational Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/scitranslmed.3000949","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,16]],"date-time":"2024-01-16T17:25:24Z","timestamp":1705425924000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/scitranslmed.3000949"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,3,17]]},"references-count":21,"journal-issue":{"issue":"23","published-print":{"date-parts":[[2010,3,17]]}},"alternative-id":["10.1126\/scitranslmed.3000949"],"URL":"https:\/\/doi.org\/10.1126\/scitranslmed.3000949","relation":{},"ISSN":["1946-6234","1946-6242"],"issn-type":[{"value":"1946-6234","type":"print"},{"value":"1946-6242","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,3,17]]}}}