{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T13:34:19Z","timestamp":1791293659185,"version":"4.1.0"},"reference-count":45,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"90","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sci. Transl. Med."],"published-print":{"date-parts":[[2011,7,6]]},"abstract":"<jats:p>Deep sequencing provides new insights about T cell receptor rearrangement in humans.<\/jats:p>","DOI":"10.1126\/scitranslmed.3002536","type":"journal-article","created":{"date-parts":[[2011,7,6]],"date-time":"2011-07-06T16:10:17Z","timestamp":1309968617000},"source":"Crossref","is-referenced-by-count":140,"title":["Deep Sequencing of the Human TCR\u03b3 and TCR\u03b2 Repertoires Suggests that TCR\u03b2 Rearranges After \u03b1\u03b2 and \u03b3\u03b4 T Cell Commitment"],"prefix":"10.1126","volume":"3","author":[{"given":"Anna M.","family":"Sherwood","sequence":"first","affiliation":[{"name":"Adaptive TCR, 307 Westlake Avenue North, Seattle, WA 98109, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cindy","family":"Desmarais","sequence":"additional","affiliation":[{"name":"Adaptive TCR, 307 Westlake Avenue North, Seattle, WA 98109, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert J.","family":"Livingston","sequence":"additional","affiliation":[{"name":"Adaptive TCR, 307 Westlake Avenue North, Seattle, WA 98109, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Andriesen","sequence":"additional","affiliation":[{"name":"Adaptive TCR, 307 Westlake Avenue North, Seattle, WA 98109, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maximilian","family":"Haussler","sequence":"additional","affiliation":[{"name":"Faculty of Life Sciences, University of Manchester, Manchester M13 9PT, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher S.","family":"Carlson","sequence":"additional","affiliation":[{"name":"Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, WA 98109, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harlan","family":"Robins","sequence":"additional","affiliation":[{"name":"Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, WA 98109, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2007.01.002"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3001442"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/322145a0"},{"key":"e_1_3_1_5_2","doi-asserted-by":"crossref","first-page":"2293","DOI":"10.4049\/jimmunol.129.5.2293","article-title":"Tumor-specific antigen of murine T-lymphoma defined with monoclonal antibody.","volume":"129","author":"Allison J. P.","year":"1982","unstructured":"Allison J. P., McIntyre B. W., Bloch D., Tumor-specific antigen of murine T-lymphoma defined with monoclonal antibody. J. Immunol. 129, 2293\u20132300 (1982).","journal-title":"J. Immunol."},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.18.1.975"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.smim.2010.04.002"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1286-4579(99)80032-X"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-065X.2006.00479.x"},{"key":"e_1_3_1_10_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.181.11.7738"},{"key":"e_1_3_1_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-065X.2006.00478.x"},{"key":"e_1_3_1_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.smim.2010.04.004"},{"key":"e_1_3_1_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-006-6020-z"},{"key":"e_1_3_1_14_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1068819"},{"key":"e_1_3_1_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1286-4579(03)00074-1"},{"key":"e_1_3_1_16_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00262-006-0235-6"},{"key":"e_1_3_1_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2005.11.007"},{"key":"e_1_3_1_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2008.04.008"},{"key":"e_1_3_1_19_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20042524"},{"key":"e_1_3_1_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.smim.2010.04.006"},{"key":"e_1_3_1_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.smim.2010.04.003"},{"key":"e_1_3_1_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.smim.2010.04.001"},{"key":"e_1_3_1_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2009.03.009"},{"key":"e_1_3_1_24_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.193.6.689"},{"key":"e_1_3_1_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2005.03.014"},{"key":"e_1_3_1_26_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-04-217604"},{"key":"e_1_3_1_27_2","first-page":"196","article-title":"The human T-cell receptor \u03b3 variable pseudogene V10 is a distinctive marker of human speciation.","volume":"43","author":"Zhang X. M.","year":"1996","unstructured":"Zhang X. M., Cathala G., Soua Z., Lefranc M. P., Huck S., The human T-cell receptor \u03b3 variable pseudogene V10 is a distinctive marker of human speciation. Immunogenetics 43, 196\u2013203 (1996).","journal-title":"Immunogenetics"},{"key":"e_1_3_1_28_2","unstructured":"M.-P. Lefranc G. Lefranc The T Cell Receptor FactBook (Academic Press London UK 2001)."},{"key":"e_1_3_1_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.humimm.2010.06.014"},{"key":"e_1_3_1_30_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.173.6.1311"},{"key":"e_1_3_1_31_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1000231"},{"key":"e_1_3_1_32_2","doi-asserted-by":"crossref","first-page":"286","DOI":"10.4049\/jimmunol.161.1.286","article-title":"Crucial role of TCR\u03b3 chain junctional region in prenyl pyrophosphate antigen recognition by \u03b3\u03b4 T cells.","volume":"161","author":"Bukowski J. F.","year":"1998","unstructured":"Bukowski J. F., Morita C. T., Band H., Brenner M. B., Crucial role of TCR\u03b3 chain junctional region in prenyl pyrophosphate antigen recognition by \u03b3\u03b4 T cells. J. Immunol. 161, 286\u2013293 (1998).","journal-title":"J. Immunol."},{"key":"e_1_3_1_33_2","doi-asserted-by":"publisher","DOI":"10.1186\/1742-4690-2-S1-P149"},{"key":"e_1_3_1_34_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M708067200"},{"key":"e_1_3_1_35_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20090348"},{"key":"e_1_3_1_36_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni.1887"},{"key":"e_1_3_1_37_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.176.3.1543"},{"key":"e_1_3_1_38_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.172.9.5544"},{"key":"e_1_3_1_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2009.02.008"},{"key":"e_1_3_1_40_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.170.5.1521"},{"key":"e_1_3_1_41_2","doi-asserted-by":"crossref","first-page":"2873","DOI":"10.4049\/jimmunol.157.7.2873","article-title":"Extrathymic origin of human \u03b3\u03b4 T cells during fetal development.","volume":"157","author":"McVay L. D.","year":"1996","unstructured":"McVay L. D., Carding S. R., Extrathymic origin of human \u03b3\u03b4 T cells during fetal development. J. Immunol. 157, 2873\u20132882 (1996).","journal-title":"J. Immunol."},{"key":"e_1_3_1_42_2","doi-asserted-by":"crossref","first-page":"5851","DOI":"10.4049\/jimmunol.160.12.5851","article-title":"The generation of human \u03b3\u03b4 T cell repertoires during fetal development.","volume":"160","author":"McVay L. D.","year":"1998","unstructured":"McVay L. D., Jaswal S. S., Kennedy C., Hayday A., Carding S. R., The generation of human \u03b3\u03b4 T cell repertoires during fetal development. J. Immunol. 160, 5851\u20135860 (1998).","journal-title":"J. Immunol."},{"key":"e_1_3_1_43_2","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0b013e32832ff1ff"},{"key":"e_1_3_1_44_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/bth945"},{"key":"e_1_3_1_45_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2105-8-280"},{"key":"e_1_3_1_46_2","doi-asserted-by":"publisher","DOI":"10.1101\/gr.229202"}],"container-title":["Science Translational Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/scitranslmed.3002536","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,16]],"date-time":"2024-01-16T12:10:04Z","timestamp":1705407004000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/scitranslmed.3002536"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,7,6]]},"references-count":45,"journal-issue":{"issue":"90","published-print":{"date-parts":[[2011,7,6]]}},"alternative-id":["10.1126\/scitranslmed.3002536"],"URL":"https:\/\/doi.org\/10.1126\/scitranslmed.3002536","relation":{},"ISSN":["1946-6234","1946-6242"],"issn-type":[{"value":"1946-6234","type":"print"},{"value":"1946-6242","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,7,6]]}}}