{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T21:10:02Z","timestamp":1790975402034,"version":"4.1.0"},"reference-count":54,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"125","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sci. Transl. Med."],"published-print":{"date-parts":[[2012,3,14]]},"abstract":"<jats:p>A new drug blocks platelet aggregation by interacting with the integrin receptor differently from current drugs that cause adverse side effects.<\/jats:p>","DOI":"10.1126\/scitranslmed.3003576","type":"journal-article","created":{"date-parts":[[2012,3,14]],"date-time":"2012-03-14T14:58:33Z","timestamp":1331737113000},"source":"Crossref","is-referenced-by-count":87,"title":["Structure-Guided Design of a High-Affinity Platelet Integrin \u03b1\n                    <sub>IIb<\/sub>\n                    \u03b2\n                    <sub>3<\/sub>\n                    Receptor Antagonist That Disrupts Mg\n                    <sup>2+<\/sup>\n                    Binding to the MIDAS"],"prefix":"10.1126","volume":"4","author":[{"given":"Jieqing","family":"Zhu","sequence":"first","affiliation":[{"name":"Immune Disease Institute, Children\u2019s Hospital Boston, and Department of Pathology, Harvard Medical School, Boston, MA 02115, USA."},{"name":"BloodCenter of Wisconsin, Medical College of Wisconsin, Milwaukee, WI 53201, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Won-Seok","family":"Choi","sequence":"additional","affiliation":[{"name":"Laboratory of Blood and Vascular Biology, Rockefeller University, New York, NY 10065, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua G.","family":"McCoy","sequence":"additional","affiliation":[{"name":"NIH Chemical Genomics Center, National Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, MD 20892, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Negri","sequence":"additional","affiliation":[{"name":"Department of Structural and Chemical Biology, Mount Sinai School of Medicine, New York, NY 10029, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianghai","family":"Zhu","sequence":"additional","affiliation":[{"name":"Immune Disease Institute, Children\u2019s Hospital Boston, and Department of Pathology, Harvard Medical School, Boston, MA 02115, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarasija","family":"Naini","sequence":"additional","affiliation":[{"name":"Laboratory of Blood and Vascular Biology, Rockefeller University, New York, NY 10065, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jihong","family":"Li","sequence":"additional","affiliation":[{"name":"Laboratory of Blood and Vascular Biology, Rockefeller University, New York, NY 10065, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Shen","sequence":"additional","affiliation":[{"name":"NIH Chemical Genomics Center, National Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, MD 20892, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenwei","family":"Huang","sequence":"additional","affiliation":[{"name":"NIH Chemical Genomics Center, National Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, MD 20892, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Bougie","sequence":"additional","affiliation":[{"name":"BloodCenter of Wisconsin, Medical College of Wisconsin, Milwaukee, WI 53201, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Rasmussen","sequence":"additional","affiliation":[{"name":"BloodCenter of Wisconsin, Medical College of Wisconsin, Milwaukee, WI 53201, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Aster","sequence":"additional","affiliation":[{"name":"BloodCenter of Wisconsin, Medical College of Wisconsin, Milwaukee, WI 53201, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Craig J.","family":"Thomas","sequence":"additional","affiliation":[{"name":"NIH Chemical Genomics Center, National Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, MD 20892, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Filizola","sequence":"additional","affiliation":[{"name":"Department of Structural and Chemical Biology, Mount Sinai School of Medicine, New York, NY 10029, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy A.","family":"Springer","sequence":"additional","affiliation":[{"name":"Immune Disease Institute, Children\u2019s Hospital Boston, and Department of Pathology, Harvard Medical School, Boston, MA 02115, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barry S.","family":"Coller","sequence":"additional","affiliation":[{"name":"Laboratory of Blood and Vascular Biology, Rockefeller University, New York, NY 10065, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(02)00971-6"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.25.022106.141618"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri2156"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2009.05245.x"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrm2799"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1177\/1177391X0800200003"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-06-077891"},{"key":"e_1_3_2_9_2","first-page":"CD002130","article-title":"Platelet glycoprotein IIb\/IIIa blockers during percutaneous coronary intervention and as the initial medical treatment of non-ST segment elevation acute coronary syndromes.","volume":"9","author":"Bosch X.","year":"2010","unstructured":"Bosch X., Marrugat J., Sanchis J., Platelet glycoprotein IIb\/IIIa blockers during percutaneous coronary intervention and as the initial medical treatment of non-ST segment elevation acute coronary syndromes. Cochrane Database Syst. Rev. 9, CD002130 (2010).","journal-title":"Cochrane Database Syst. Rev."},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V100.6.2071"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI36745"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.2165\/00129784-200101060-00002"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.2174\/1381612043384673"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11239-006-8669-4"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0037-1614176"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V80.10.2539.2539"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V92.9.3240"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11239-006-8785-1"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.103.2.201"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-02-0471"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000255307.65939.59"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2008.11.018"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200801146"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature02976"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/cdg445"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.4244\/EIJV4I5A110"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.2008.141648"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200106213442503"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-08-105544"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-08-169243"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-04-281154"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V74.1.182.182"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.270.20.11947"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)39332-9"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.99.6.2056"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200908045"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(91)90458-B"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1021\/bi900475k"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2007.02351.x"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V92.10.3675"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1021\/bi1009858"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1161\/hc3701.095950"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.94.5.1973"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.2392682"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1064535"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M602856200"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0b013e3182009701"},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.95.7.1755"},{"key":"e_1_3_2_49_2","first-page":"539","article-title":"Early abciximab use in ST-elevation myocardial infarction treated with primary percutaneous coronary intervention improves long-term outcome. Data from EUROTRANSFER Registry.","volume":"68","author":"Siudak Z.","year":"2010","unstructured":"Siudak Z., Rakowski T., Dziewierz A., Janzon M., Birkemeyer R., Stefaniak J., Partyka \u0141., Zmudka K., Dudek D., Early abciximab use in ST-elevation myocardial infarction treated with primary percutaneous coronary intervention improves long-term outcome. Data from EUROTRANSFER Registry. Kardiol. Pol. 68, 539\u2013543 (2010).","journal-title":"Kardiol. Pol."},{"key":"e_1_3_2_50_2","article-title":"Glycoprotein IIb-IIIa inhibitors.","author":"De Luca G.","year":"2011","unstructured":"De Luca G., Glycoprotein IIb-IIIa inhibitors. Cardiovasc. Ther. 10.1111\/j.1755-5922.2011.00293.x (2011).","journal-title":"Cardiovasc. Ther."},{"key":"e_1_3_2_51_2","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1002\/ccd.21980","article-title":"In-ambulance abciximab administration in STEMI patients prior to primary PCI is associated with smaller infarct size, improved LV function and lower incidence of heart failure: Results from the Leiden MISSION! acute myocardial infarction treatment optimization program.","volume":"74","author":"Hassan A. K.","year":"2009","unstructured":"Hassan A. K., Liem S. S., van der Kley F., Bergheanu S. C., Wolterbeek R., Bosch J., Bootsma M., Zeppenfeld K., van der Laarse A., Atsma D. E., Jukema J. W., Schalij M. J., In-ambulance abciximab administration in STEMI patients prior to primary PCI is associated with smaller infarct size, improved LV function and lower incidence of heart failure: Results from the Leiden MISSION! acute myocardial infarction treatment optimization program. Catheter Cardiovasc. Interv. 74, 335\u2013343 (2009).","journal-title":"Catheter Cardiovasc. Interv."},{"key":"e_1_3_2_52_2","doi-asserted-by":"publisher","DOI":"10.1038\/nbt1373"},{"key":"e_1_3_2_53_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.110.951970"},{"key":"e_1_3_2_54_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0076-6879(09)64011-8"},{"key":"e_1_3_2_55_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2009.10.024"}],"container-title":["Science Translational Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/scitranslmed.3003576","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,16]],"date-time":"2024-01-16T13:27:29Z","timestamp":1705411649000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/scitranslmed.3003576"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,3,14]]},"references-count":54,"journal-issue":{"issue":"125","published-print":{"date-parts":[[2012,3,14]]}},"alternative-id":["10.1126\/scitranslmed.3003576"],"URL":"https:\/\/doi.org\/10.1126\/scitranslmed.3003576","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.718404922.793523508","asserted-by":"object"}]},"ISSN":["1946-6234","1946-6242"],"issn-type":[{"value":"1946-6234","type":"print"},{"value":"1946-6242","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,3,14]]}}}