{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T16:20:41Z","timestamp":1793118041338,"version":"4.5.0"},"reference-count":51,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"137","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sci. Transl. Med."],"published-print":{"date-parts":[[2012,6,6]]},"abstract":"<jats:p>Preexisting immunity to BCG improves treatment response to intravesical BCG therapy for bladder cancer in mouse models and humans.<\/jats:p>","DOI":"10.1126\/scitranslmed.3003586","type":"journal-article","created":{"date-parts":[[2012,6,6]],"date-time":"2012-06-06T14:58:48Z","timestamp":1338994728000},"source":"Crossref","is-referenced-by-count":249,"title":["Preexisting BCG-Specific T Cells Improve Intravesical Immunotherapy for Bladder Cancer"],"prefix":"10.1126","volume":"4","author":[{"given":"Claire","family":"Biot","sequence":"first","affiliation":[{"name":"Unit\u00e9 d\u2019Immunobiologie des Cellules Dendritiques, Department of Immunology, Institut Pasteur, F-75724 Paris, France."},{"name":"INSERM U818, F-75654 Paris, France."},{"name":"MINES ParisTech, F-75272 Paris, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cyrill A.","family":"Rentsch","sequence":"additional","affiliation":[{"name":"Unit\u00e9 d\u2019Immunobiologie des Cellules Dendritiques, Department of Immunology, Institut Pasteur, F-75724 Paris, France."},{"name":"INSERM U818, F-75654 Paris, France."},{"name":"Department of Urology, University Hospital of Basel, CH-4031 Basel, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joel R.","family":"Gsponer","sequence":"additional","affiliation":[{"name":"Unit\u00e9 d\u2019Immunobiologie des Cellules Dendritiques, Department of Immunology, Institut Pasteur, F-75724 Paris, France."},{"name":"INSERM U818, F-75654 Paris, France."},{"name":"Department of Urology, University Hospital of Basel, CH-4031 Basel, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fr\u00e9d\u00e9ric D.","family":"Birkh\u00e4user","sequence":"additional","affiliation":[{"name":"Department of Urology, University of Bern, Inselspital, CH-3010 Bern, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H\u00e9l\u00e8ne","family":"Jusforgues-Saklani","sequence":"additional","affiliation":[{"name":"Unit\u00e9 d\u2019Immunobiologie des Cellules Dendritiques, Department of Immunology, Institut Pasteur, F-75724 Paris, France."},{"name":"INSERM U818, F-75654 Paris, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabrice","family":"Lema\u00eetre","sequence":"additional","affiliation":[{"name":"Unit\u00e9 des Dynamiques des R\u00e9ponses Immunes, Department of Immunology, Institut Pasteur, F-75724 Paris, France."},{"name":"INSERM U668, F-75654 Paris, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlotte","family":"Auriau","sequence":"additional","affiliation":[{"name":"Unit\u00e9 d\u2019Immunobiologie des Cellules Dendritiques, Department of Immunology, Institut Pasteur, F-75724 Paris, France."},{"name":"INSERM U818, F-75654 Paris, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Bachmann","sequence":"additional","affiliation":[{"name":"Department of Urology, University of Bern, Inselspital, CH-3010 Bern, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Bousso","sequence":"additional","affiliation":[{"name":"Unit\u00e9 des Dynamiques des R\u00e9ponses Immunes, Department of Immunology, Institut Pasteur, F-75724 Paris, France."},{"name":"INSERM U668, F-75654 Paris, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Demangel","sequence":"additional","affiliation":[{"name":"Institut Pasteur, Unit\u00e9 d\u2019Immunobiologie de l\u2019Infection, Department of Immunology, F-75015 Paris, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucie","family":"Peduto","sequence":"additional","affiliation":[{"name":"Unit\u00e9 de D\u00e9veloppement des Tissus Lympho\u00efdes, Department of Immunology, Institut Pasteur, F-75724 Paris, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George N.","family":"Thalmann","sequence":"additional","affiliation":[{"name":"Department of Urology, University of Bern, Inselspital, CH-3010 Bern, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew L.","family":"Albert","sequence":"additional","affiliation":[{"name":"Unit\u00e9 d\u2019Immunobiologie des Cellules Dendritiques, Department of Immunology, Institut Pasteur, F-75724 Paris, France."},{"name":"INSERM U818, F-75654 Paris, France."},{"name":"Universit\u00e9 Paris Descartes, F-75270 Paris, France."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.3322\/caac.20107"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2011.03.017"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(17)58737-6"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2009.11.023"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1001012"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/mi.2011.14"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.021908.132703"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/mi.2011.10"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.2217\/imt.10.32"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2007.05.004"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(17)43909-7"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(17)35678-1"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0215(20010601)92:5<697::AID-IJC1245>3.0.CO;2-Z"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-06-1416"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(17)37668-1"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2008.11.124"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(17)46976-X"},{"key":"e_1_3_2_19_2","first-page":"341","article-title":"Tumor regression mediated by Mycobacterium bovis (strain BCG)","volume":"35","author":"Zbar B.","year":"1972","unstructured":"Zbar B., Tumor regression mediated by Mycobacterium bovis (strain BCG). Natl. Cancer Inst. Monogr. 35, 341\u2013344 (1972).","journal-title":"Natl. Cancer Inst. Monogr."},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20071367"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0801496105"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.70.8.4501-4509.2002"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(05)66410-5"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.01595-10"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.73.9.5809-5816.2005"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.2009.08577.x"},{"key":"e_1_3_2_27_2","first-page":"2834","article-title":"Optimizing syngeneic orthotopic murine bladder cancer (MB49)","volume":"59","author":"G\u00fcnther J. H.","year":"1999","unstructured":"G\u00fcnther J. H., Jurczok A., Wulf T., Brandau S., Deinert I., Jocham D., B\u00f6hle A., Optimizing syngeneic orthotopic murine bladder cancer (MB49). Cancer Res. 59, 2834\u20132837 (1999).","journal-title":"Cancer Res."},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(69)92648-8"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-197010000-00018"},{"key":"e_1_3_2_30_2","first-page":"831","article-title":"Suppression of tumor growth at the site of infection with living Bacillus Calmette-Gu\u00e9rin","volume":"46","author":"Zbar B.","year":"1971","unstructured":"Zbar B., Bernstein I. D., Rapp H. J., Suppression of tumor growth at the site of infection with living Bacillus Calmette-Gu\u00e9rin. J. Natl. Cancer Inst. 46, 831\u2013839 (1971).","journal-title":"J. Natl. Cancer Inst."},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2007.08.122"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.urolonc.2008.10.024"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1155\/2011\/728930"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00262987"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2011.06.002"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tube.2004.10.001"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.2008.08274.x"},{"key":"e_1_3_2_38_2","doi-asserted-by":"crossref","first-page":"954","DOI":"10.4049\/jimmunol.129.3.954","article-title":"Local adoptive transfer of skin delayed-type hypersensitivity initiated by a single T lymphocyte","volume":"129","author":"Marchal G.","year":"1982","unstructured":"Marchal G., Seman M., Milon G., Truffa-Bachi P., Zilberfarb V., Local adoptive transfer of skin delayed-type hypersensitivity initiated by a single T lymphocyte. J. Immunol. 129, 954\u2013958 (1982).","journal-title":"J. Immunol."},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01978763"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1987.5.3.441"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-4295(97)00067-8"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.ju.0000150425.09317.67"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(17)45605-9"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(17)42723-6"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(17)38439-2"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(01)66427-9"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.1990.tb14861.x"},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.ju.0000059681.67567.12"},{"key":"e_1_3_2_49_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.0030185"},{"key":"e_1_3_2_50_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(00)80599-3"},{"key":"e_1_3_2_51_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0803974"},{"key":"e_1_3_2_52_2","doi-asserted-by":"crossref","first-page":"4069","DOI":"10.4049\/jimmunol.147.12.4069","article-title":"In vivo induction of cytotoxic T cell response by a free synthetic peptide requires CD4+ T cell help","volume":"147","author":"Fayolle C.","year":"1991","unstructured":"Fayolle C., Deriaud E., Leclerc C., In vivo induction of cytotoxic T cell response by a free synthetic peptide requires CD4+ T cell help. J. Immunol. 147, 4069\u20134073 (1991).","journal-title":"J. Immunol."}],"container-title":["Science Translational Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/scitranslmed.3003586","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,16]],"date-time":"2024-01-16T13:16:26Z","timestamp":1705410986000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/scitranslmed.3003586"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,6,6]]},"references-count":51,"journal-issue":{"issue":"137","published-print":{"date-parts":[[2012,6,6]]}},"alternative-id":["10.1126\/scitranslmed.3003586"],"URL":"https:\/\/doi.org\/10.1126\/scitranslmed.3003586","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.717959353.793462805","asserted-by":"object"}]},"ISSN":["1946-6234","1946-6242"],"issn-type":[{"value":"1946-6234","type":"print"},{"value":"1946-6242","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,6,6]]}}}