{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T15:34:47Z","timestamp":1791128087730,"version":"4.1.0"},"reference-count":15,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"151","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sci. Transl. Med."],"published-print":{"date-parts":[[2012,9,12]]},"abstract":"<jats:p>Clinical effectiveness for interventions in humans can only be speculated from animal studies.<\/jats:p>","DOI":"10.1126\/scitranslmed.3004631","type":"journal-article","created":{"date-parts":[[2012,9,12]],"date-time":"2012-09-12T17:22:26Z","timestamp":1347470546000},"source":"Crossref","is-referenced-by-count":101,"title":["Extrapolating from Animals to Humans"],"prefix":"10.1126","volume":"4","author":[{"given":"John P. A.","family":"Ioannidis","sequence":"first","affiliation":[{"name":"Stanford Prevention Research Center, Department of Medicine and Department of Health Research and Policy, Stanford University School of Medicine, and Department of Statistics, Stanford University School of Humanities and Sciences, Stanford, CA 94305, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3004073"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.39048.407928.BE"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.328.7438.514"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.0020124"},{"key":"e_1_3_1_6_2","doi-asserted-by":"crossref","unstructured":"Bebarta V. Luyten D. Heard K. Emergency medicine animal research: Does use of randomization and blinding affect the results? Acad. Emerg. Med. 10 684\u2013687 (2003) PubMed.","DOI":"10.1111\/j.1553-2712.2003.tb00056.x"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.107.498725"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1747-4949.2012.00797.x"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.1000344"},{"key":"e_1_3_1_10_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000125719.25853.20"},{"key":"e_1_3_1_11_2","doi-asserted-by":"publisher","DOI":"10.1177\/0300985810372506"},{"key":"e_1_3_1_12_2","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/507571"},{"key":"e_1_3_1_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(11)60970-7"},{"key":"e_1_3_1_14_2","doi-asserted-by":"publisher","DOI":"10.2105\/AJPH.52.4.632"},{"key":"e_1_3_1_15_2","doi-asserted-by":"publisher","DOI":"10.1177\/1545968308326636"},{"key":"e_1_3_1_16_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.1000412"}],"container-title":["Science Translational Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/scitranslmed.3004631","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,16]],"date-time":"2024-01-16T11:58:41Z","timestamp":1705406321000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/scitranslmed.3004631"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,9,12]]},"references-count":15,"journal-issue":{"issue":"151","published-print":{"date-parts":[[2012,9,12]]}},"alternative-id":["10.1126\/scitranslmed.3004631"],"URL":"https:\/\/doi.org\/10.1126\/scitranslmed.3004631","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.717959619.793462898","asserted-by":"object"}]},"ISSN":["1946-6234","1946-6242"],"issn-type":[{"value":"1946-6234","type":"print"},{"value":"1946-6242","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,9,12]]}}}