{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T23:31:02Z","timestamp":1792798262683,"version":"4.5.0"},"reference-count":58,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"177","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sci. Transl. Med."],"published-print":{"date-parts":[[2013,3,20]]},"abstract":"<jats:p>ELQ-300, an investigational drug for treating and preventing malaria, shows potent transmission-blocking activity in rodent models of malaria.<\/jats:p>","DOI":"10.1126\/scitranslmed.3005029","type":"journal-article","created":{"date-parts":[[2013,3,20]],"date-time":"2013-03-20T18:09:08Z","timestamp":1363802948000},"source":"Crossref","is-referenced-by-count":209,"title":["Quinolone-3-Diarylethers: A New Class of Antimalarial Drug"],"prefix":"10.1126","volume":"5","author":[{"given":"Aaron","family":"Nilsen","sequence":"first","affiliation":[{"name":"Veterans Affairs Medical Center, 3710 Southwest U.S. Veterans Hospital Road, Portland, OR 97239, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexis N.","family":"LaCrue","sequence":"additional","affiliation":[{"name":"Department of Global Health, College of Public Health, 3720 Spectrum Boulevard (Suite 304), Tampa, FL 33612, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen L.","family":"White","sequence":"additional","affiliation":[{"name":"Centre for Drug Candidate Optimisation, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria 3052, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isaac P.","family":"Forquer","sequence":"additional","affiliation":[{"name":"Veterans Affairs Medical Center, 3710 Southwest U.S. Veterans Hospital Road, Portland, OR 97239, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. Matthew","family":"Cross","sequence":"additional","affiliation":[{"name":"Department of Chemistry, University of South Florida, 4202 East Fowler Avenue, Tampa, FL 33620\u20135250, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jutta","family":"Marfurt","sequence":"additional","affiliation":[{"name":"Global and Tropical Health Division, Menzies School of Health Research and Charles Darwin University, PO Box 41096, Casuarina, NT 0811, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael W.","family":"Mather","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Drexel University College of Medicine, 2900 Queen Lane, Philadelphia, PA 19129, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J.","family":"Delves","sequence":"additional","affiliation":[{"name":"Department of Life Sciences, Imperial College London, London SW7 2AZ, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David M.","family":"Shackleford","sequence":"additional","affiliation":[{"name":"Centre for Drug Candidate Optimisation, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria 3052, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabian E.","family":"Saenz","sequence":"additional","affiliation":[{"name":"Department of Global Health, College of Public Health, 3720 Spectrum Boulevard (Suite 304), Tampa, FL 33612, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanne M.","family":"Morrisey","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Drexel University College of Medicine, 2900 Queen Lane, Philadelphia, PA 19129, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Steuten","sequence":"additional","affiliation":[{"name":"Centre for Drug Candidate Optimisation, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria 3052, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tina","family":"Mutka","sequence":"additional","affiliation":[{"name":"Department of Global Health, College of Public Health, 3720 Spectrum Boulevard (Suite 304), Tampa, FL 33612, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuexin","family":"Li","sequence":"additional","affiliation":[{"name":"Veterans Affairs Medical Center, 3710 Southwest U.S. Veterans Hospital Road, Portland, OR 97239, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grennady","family":"Wirjanata","sequence":"additional","affiliation":[{"name":"Global and Tropical Health Division, Menzies School of Health Research and Charles Darwin University, PO Box 41096, Casuarina, NT 0811, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eileen","family":"Ryan","sequence":"additional","affiliation":[{"name":"Centre for Drug Candidate Optimisation, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria 3052, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Duffy","sequence":"additional","affiliation":[{"name":"Eskitis Institute for Cell and Molecular Therapies, Brisbane Innovation Park, Nathan Campus, Griffith University, Brisbane, Queensland 4111, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jane Xu","family":"Kelly","sequence":"additional","affiliation":[{"name":"Veterans Affairs Medical Center, 3710 Southwest U.S. Veterans Hospital Road, Portland, OR 97239, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boni F.","family":"Sebayang","sequence":"additional","affiliation":[{"name":"Eijkman Institute for Molecular Biology, Jl. Diponegoro 69, Jakarta 10430, Indonesia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne-Marie","family":"Zeeman","sequence":"additional","affiliation":[{"name":"Department of Parasitology, Biomedical Primate Research Centre, P. O. Box 3306, 2280 GH Rijswijk, the Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rintis","family":"Noviyanti","sequence":"additional","affiliation":[{"name":"Eijkman Institute for Molecular Biology, Jl. Diponegoro 69, Jakarta 10430, Indonesia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert E.","family":"Sinden","sequence":"additional","affiliation":[{"name":"Department of Life Sciences, Imperial College London, London SW7 2AZ, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clemens H. M.","family":"Kocken","sequence":"additional","affiliation":[{"name":"Department of Parasitology, Biomedical Primate Research Centre, P. O. Box 3306, 2280 GH Rijswijk, the Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ric N.","family":"Price","sequence":"additional","affiliation":[{"name":"Global and Tropical Health Division, Menzies School of Health Research and Charles Darwin University, PO Box 41096, Casuarina, NT 0811, Australia."},{"name":"Centre for Tropical Medicine, Nuffield Department of Clinical Medicine, University of Oxford, Oxford OX3 7LJ, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vicky M.","family":"Avery","sequence":"additional","affiliation":[{"name":"Eskitis Institute for Cell and Molecular Therapies, Brisbane Innovation Park, Nathan Campus, Griffith University, Brisbane, Queensland 4111, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I\u00f1igo","family":"Angulo-Barturen","sequence":"additional","affiliation":[{"name":"GlaxoSmithKline, Medicines Development Campus, Diseases of the Developing World, Severo Ochoa 2, Tres Cantos 28760, Madrid, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Bel\u00e9n","family":"Jim\u00e9nez-D\u00edaz","sequence":"additional","affiliation":[{"name":"GlaxoSmithKline, Medicines Development Campus, Diseases of the Developing World, Severo Ochoa 2, Tres Cantos 28760, Madrid, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Santiago","family":"Ferrer","sequence":"additional","affiliation":[{"name":"GlaxoSmithKline, Medicines Development Campus, Diseases of the Developing World, Severo Ochoa 2, Tres Cantos 28760, Madrid, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esperanza","family":"Herreros","sequence":"additional","affiliation":[{"name":"GlaxoSmithKline, Medicines Development Campus, Diseases of the Developing World, Severo Ochoa 2, Tres Cantos 28760, Madrid, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura M.","family":"Sanz","sequence":"additional","affiliation":[{"name":"GlaxoSmithKline, Medicines Development Campus, Diseases of the Developing World, Severo Ochoa 2, Tres Cantos 28760, Madrid, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco-Javier","family":"Gamo","sequence":"additional","affiliation":[{"name":"GlaxoSmithKline, Medicines Development Campus, Diseases of the Developing World, Severo Ochoa 2, Tres Cantos 28760, Madrid, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian","family":"Bathurst","sequence":"additional","affiliation":[{"name":"Medicines for Malaria Venture, 20, route de Pr\u00e9-Bois, P. O. Box 1826, 1215 Geneva 15, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeremy N.","family":"Burrows","sequence":"additional","affiliation":[{"name":"Medicines for Malaria Venture, 20, route de Pr\u00e9-Bois, P. O. Box 1826, 1215 Geneva 15, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Siegl","sequence":"additional","affiliation":[{"name":"Siegl Pharma Consulting LLC, Blue Bell, PA 19422, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. Kiplin","family":"Guy","sequence":"additional","affiliation":[{"name":"Chemical Biology and Therapeutics, St. Jude Children\u2019s Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105\u20133678, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rolf W.","family":"Winter","sequence":"additional","affiliation":[{"name":"Veterans Affairs Medical Center, 3710 Southwest U.S. Veterans Hospital Road, Portland, OR 97239, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akhil B.","family":"Vaidya","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Drexel University College of Medicine, 2900 Queen Lane, Philadelphia, PA 19129, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan A.","family":"Charman","sequence":"additional","affiliation":[{"name":"Centre for Drug Candidate Optimisation, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria 3052, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dennis E.","family":"Kyle","sequence":"additional","affiliation":[{"name":"Department of Global Health, College of Public Health, 3720 Spectrum Boulevard (Suite 304), Tampa, FL 33612, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roman","family":"Manetsch","sequence":"additional","affiliation":[{"name":"Department of Chemistry, University of South Florida, 4202 East Fowler Avenue, Tampa, FL 33620\u20135250, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael K.","family":"Riscoe","sequence":"additional","affiliation":[{"name":"Veterans Affairs Medical Center, 3710 Southwest U.S. Veterans Hospital Road, Portland, OR 97239, USA."},{"name":"Department of Molecular Microbiology and Immunology, 3181 Sam Jackson Boulevard, Portland, OR 97239, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)60034-8"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMp1108322"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)60484-X"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.4155\/fmc.12.188"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1000402"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/cber.19480810103"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02184020"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1021\/jm1007903"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.exppara.2010.10.016"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(92)90213-3"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1021\/jm0705760"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.4155\/fmc.12.177"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.exppara.2007.10.016"},{"key":"e_1_3_2_15_2","unstructured":"M. K. Riscoe J. X. Kelly R. W. Winter D. J. Hinrichs M. J. Smilkstein A. Nilsen J. Burrows D. E. Kyle M. Manetsch R. M. Cross A. Monastyrskyi D. L. Flanigan WIPO #WO\/2010\/065905 (2010)."},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.48.5.1803-1806.2004"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.16.6.710"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molbiopara.2008.01.002"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1128\/EC.05049-11"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature05572"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01220-10"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01334-07"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molbiopara.2010.07.006"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0030949"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.48.11.4097-4102.2004"},{"key":"e_1_3_2_26_2","doi-asserted-by":"crossref","unstructured":"A. J. Ager Rodent Malaria Models (Springer-Verlag New York 1984) vol. 68 pp. 225\u2013264.","DOI":"10.1007\/978-3-642-69251-2_8"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00519-09"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1002\/cyto.a.20169"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0018162"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1205651109"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.24.5.615"},{"key":"e_1_3_2_32_2","unstructured":"W. Peters in Epidemiology Chemotherapy Morphology and Metabolism J. P. Kreier Ed. (Academic Press New York 1980) pp. 214\u2013283."},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.2012.11-0302"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1001169"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpara.2012.08.009"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2006.53"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1186\/1475-2875-9-35"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.06377-11"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1208069109"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.781840"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01375-10"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1006\/expr.1999.4344"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00793-12"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0007881"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1021\/jm200718m"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.1021\/jm0505718"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.1016\/0035-9203(77)90025-6"},{"key":"e_1_3_2_48_2","first-page":"1007","article-title":"Mitochondrial ubiquinol-cytochrome c reductase and cytochrome c oxidase: Chemotherapeutic targets in malarial parasites.","volume":"42","author":"Krungkrai J.","year":"1997","unstructured":"Krungkrai J., Krungkrai S. R., Suraveratum N., Prapunwattana P., Mitochondrial ubiquinol-cytochrome c reductase and cytochrome c oxidase: Chemotherapeutic targets in malarial parasites. Biochem. Mol. Biol. Int. 42, 1007\u20131014 (1997).","journal-title":"Biochem. Mol. Biol. Int."},{"key":"e_1_3_2_49_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182004005888"},{"key":"e_1_3_2_50_2","doi-asserted-by":"publisher","DOI":"10.1002\/bit.20072"},{"key":"e_1_3_2_51_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)86947-8"},{"key":"e_1_3_2_52_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0002252"},{"key":"e_1_3_2_53_2","doi-asserted-by":"publisher","DOI":"10.1002\/cyto.a.20647"},{"key":"e_1_3_2_54_2","doi-asserted-by":"crossref","first-page":"1350","DOI":"10.1016\/S0090-9556(24)14938-0","article-title":"Prediction of human clearance of twenty-nine drugs from hepatic microsomal intrinsic clearance data: An examination of in vitro half-life approach and nonspecific binding to microsomes.","volume":"27","author":"Obach R. S.","year":"1999","unstructured":"Obach R. S., Prediction of human clearance of twenty-nine drugs from hepatic microsomal intrinsic clearance data: An examination of in vitro half-life approach and nonspecific binding to microsomes. Drug Metab. Dispos. 27, 1350\u20131359 (1999).","journal-title":"Drug Metab. Dispos."},{"key":"e_1_3_2_55_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V68.2.530.530"},{"key":"e_1_3_2_56_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V96.13.4204"},{"key":"e_1_3_2_57_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxlet.2009.01.005"},{"key":"e_1_3_2_58_2","doi-asserted-by":"publisher","DOI":"10.1586\/14737159.7.2.161"},{"key":"e_1_3_2_59_2","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfm052"}],"container-title":["Science Translational Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/scitranslmed.3005029","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,30]],"date-time":"2025-04-30T01:11:41Z","timestamp":1745975501000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/scitranslmed.3005029"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,3,20]]},"references-count":58,"journal-issue":{"issue":"177","published-print":{"date-parts":[[2013,3,20]]}},"alternative-id":["10.1126\/scitranslmed.3005029"],"URL":"https:\/\/doi.org\/10.1126\/scitranslmed.3005029","relation":{},"ISSN":["1946-6234","1946-6242"],"issn-type":[{"value":"1946-6234","type":"print"},{"value":"1946-6242","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,3,20]]}}}