{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T05:38:12Z","timestamp":1790746692904,"version":"4.1.0"},"reference-count":49,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"205","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sci. Transl. Med."],"published-print":{"date-parts":[[2013,10,2]]},"abstract":"<jats:p>An in vitro system can determine the pharmacokinetic drivers of antimalarial drug pharmacodynamics, leading to more rationally developed new drug candidates.<\/jats:p>","DOI":"10.1126\/scitranslmed.3006684","type":"journal-article","created":{"date-parts":[[2013,10,2]],"date-time":"2013-10-02T18:26:08Z","timestamp":1380738368000},"source":"Crossref","is-referenced-by-count":35,"title":["Model System to Define Pharmacokinetic Requirements for Antimalarial Drug Efficacy"],"prefix":"10.1126","volume":"5","author":[{"given":"Rahul P.","family":"Bakshi","sequence":"first","affiliation":[{"name":"Division of Clinical Pharmacology, Department of Medicine, Johns Hopkins University, 725 North Wolfe Street, Baltimore, MD 21205, USA."},{"name":"Johns Hopkins Malaria Research Institute, Johns Hopkins University, Baltimore, MD 21205, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Nenortas","sequence":"additional","affiliation":[{"name":"Division of Clinical Pharmacology, Department of Medicine, Johns Hopkins University, 725 North Wolfe Street, Baltimore, MD 21205, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abhai K.","family":"Tripathi","sequence":"additional","affiliation":[{"name":"Johns Hopkins Malaria Research Institute, Johns Hopkins University, Baltimore, MD 21205, USA."},{"name":"Department of Molecular Microbiology and Immunology, Johns Hopkins University, Baltimore, MD 21205, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David J.","family":"Sullivan","sequence":"additional","affiliation":[{"name":"Johns Hopkins Malaria Research Institute, Johns Hopkins University, Baltimore, MD 21205, USA."},{"name":"Department of Molecular Microbiology and Immunology, Johns Hopkins University, Baltimore, MD 21205, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theresa A.","family":"Shapiro","sequence":"additional","affiliation":[{"name":"Division of Clinical Pharmacology, Department of Medicine, Johns Hopkins University, 725 North Wolfe Street, Baltimore, MD 21205, USA."},{"name":"Johns Hopkins Malaria Research Institute, Johns Hopkins University, Baltimore, MD 21205, USA."},{"name":"Department of Molecular Microbiology and Immunology, Johns Hopkins University, Baltimore, MD 21205, USA."},{"name":"Department of Pharmacology and Molecular Sciences, Johns Hopkins University, Baltimore, MD 21205, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","unstructured":"World Health Organization World Malaria Report 2010 (World Health Organization Geneva 2010)."},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)60034-8"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0808859"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2012.02.021"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature01097"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature09107"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature09099"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1193225"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrd1230"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.2009.286"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1086\/516284"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01629-10"},{"key":"e_1_3_2_14_2","doi-asserted-by":"crossref","unstructured":"G. W. Amsden C. H. Ballow J. S. Bertino A. D. M. Kashuba in Mandell Douglas and Bennett\u2019s Principles and Practice of Infectious Diseases G. L. Mandell J. E. Bennett R. Dolin Eds. (Churchill Livingstone Philadelphia PA 2010) vol. 1 pp. 297\u2013308.","DOI":"10.1016\/B978-0-443-06839-3.00020-5"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro862"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(93)90137-6"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.43.7.1549"},{"key":"e_1_3_2_18_2","first-page":"2629","article-title":"Evaluation of cell-killing effects of 1-\u03b2-d-arabinofuranosylcytosine and daunorubicin by a new computer-controlled in vitro pharmacokinetic simulation system.","volume":"59","author":"Kishi S.","year":"1999","unstructured":"Kishi S., Goto N., Nakamura T., Ueda T., Evaluation of cell-killing effects of 1-\u03b2-d-arabinofuranosylcytosine and daunorubicin by a new computer-controlled in vitro pharmacokinetic simulation system. Cancer Res. 59, 2629\u20132634 (1999).","journal-title":"Cancer Res."},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2008.11.001"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0002252"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/15.suppl_A.131"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.38.10.2404"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.781840"},{"key":"e_1_3_2_24_2","unstructured":"T. A. Shapiro D. E. Goldberg in Goodman and Gilman\u2019s The pharmacological Basis of Therapeutics L. L. Brunton J. S. Lazo K. L. Parker Eds. (McGraw-Hill Companies New York 2006) pp. 1021\u20131047."},{"key":"e_1_3_2_25_2","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/S0026-895X(25)13895-9","article-title":"Antimalarial activity of selected aromatic chelators. II. Substituted quinolines and quinoline-N-oxides.","volume":"20","author":"Scheibel L. W.","year":"1981","unstructured":"Scheibel L. W., Adler A., Antimalarial activity of selected aromatic chelators. II. Substituted quinolines and quinoline-N-oxides. Mol. Pharmacol. 20, 218\u2013223 (1981).","journal-title":"Mol. Pharmacol."},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.27.1.21"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1186\/1475-2875-10-310"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.2007.76.1024"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1205216"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1000214"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2164-12-391"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1186\/1475-2875-10-4"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1086\/345876"},{"key":"e_1_3_2_34_2","first-page":"761","article-title":"Optimizing the culture of Plasmodium falciparum in hollow fiber bioreactors.","volume":"41","author":"Preechapornkul P.","year":"2010","unstructured":"Preechapornkul P., Chotivanich K., Imwong M., Dondorp A. M., Lee S. J., Day N. P., White N. J., Pukrittayakamee S., Optimizing the culture of Plasmodium falciparum in hollow fiber bioreactors. Southeast Asian J. Trop. Med. Public Health 41, 761\u2013769 (2010).","journal-title":"Southeast Asian J. Trop. Med. Public Health"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.2165\/00003088-199630040-00002"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2125.2001.01458.x"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00228-006-0203-2"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1217452110"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.1997.56.17"},{"key":"e_1_3_2_40_2","first-page":"539","article-title":"Double blind randomised clinical trial of oral artesunate at once or twice daily dose in falciparum malaria.","volume":"22","author":"Bunnag D.","year":"1991","unstructured":"Bunnag D., Viravan C., Looareesuwan S., Karbwang J., Harinasuta T., Double blind randomised clinical trial of oral artesunate at once or twice daily dose in falciparum malaria. Southeast Asian J. Trop. Med. Public Health 22, 539\u2013543 (1991).","journal-title":"Southeast Asian J. Trop. Med. Public Health"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.1994.50.771"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.37.5.1102"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1016\/0035-9203(95)90671-1"},{"key":"e_1_3_2_44_2","unstructured":"F. Mphande S. Nillson A. Bolad in Methods in Malaria Research K. Moll I. Ljungstrom H. Perlmann A. Scherf M. Wahlgren Eds. (Malaria Research and Reference Reagent Resource Center (MR4) Manassas VA 2008) pp. 1\u20133."},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4894(79)90094-8"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00034.2002"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-1033.1997.00670.x"},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.16.6.710"},{"key":"e_1_3_2_49_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0040-4020(96)00975-1"},{"key":"e_1_3_2_50_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01533-06"}],"container-title":["Science Translational Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/scitranslmed.3006684","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,30]],"date-time":"2025-04-30T15:21:18Z","timestamp":1746026478000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/scitranslmed.3006684"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,10,2]]},"references-count":49,"journal-issue":{"issue":"205","published-print":{"date-parts":[[2013,10,2]]}},"alternative-id":["10.1126\/scitranslmed.3006684"],"URL":"https:\/\/doi.org\/10.1126\/scitranslmed.3006684","relation":{},"ISSN":["1946-6234","1946-6242"],"issn-type":[{"value":"1946-6234","type":"print"},{"value":"1946-6242","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,10,2]]}}}