{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T01:08:11Z","timestamp":1793495291392,"version":"4.5.0"},"reference-count":50,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"248","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sci. Transl. Med."],"published-print":{"date-parts":[[2014,8,6]]},"abstract":"<jats:p>In multiple sclerosis patients, B cells mature in the draining cervical lymph nodes before trafficking across the blood-brain barrier.<\/jats:p>","DOI":"10.1126\/scitranslmed.3008879","type":"journal-article","created":{"date-parts":[[2014,8,6]],"date-time":"2014-08-06T14:30:51Z","timestamp":1407335451000},"source":"Crossref","is-referenced-by-count":433,"title":["B cells populating the multiple sclerosis brain mature in the draining cervical lymph nodes"],"prefix":"10.1126","volume":"6","author":[{"given":"Joel N. H.","family":"Stern","sequence":"first","affiliation":[{"name":"Department of Neurology, Yale School of Medicine, New Haven, CT 06511, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gur","family":"Yaari","sequence":"additional","affiliation":[{"name":"Department of Pathology, Yale School of Medicine, New Haven, CT 06511, USA."},{"name":"Bioengineering Program, Faculty of Engineering, Bar-Ilan University, Ramat Gan 52900, Israel."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason A.","family":"Vander Heiden","sequence":"additional","affiliation":[{"name":"Interdepartmental Program in Computational Biology and Bioinformatics, Yale University, New Haven, CT 06511, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"Church","sequence":"additional","affiliation":[{"name":"Department of Genetics, Harvard Medical School, Boston, MA 02115, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William F.","family":"Donahue","sequence":"additional","affiliation":[{"name":"AbVitro Incorporated, Boston, MA 02210, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rogier Q.","family":"Hintzen","sequence":"additional","affiliation":[{"name":"Department of Neurology, Erasmus MC, University Medical Center Rotterdam, and MS Centrum ErasMS, 3000 CA Rotterdam, the Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anita J.","family":"Huttner","sequence":"additional","affiliation":[{"name":"Department of Pathology, Yale School of Medicine, New Haven, CT 06511, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jon D.","family":"Laman","sequence":"additional","affiliation":[{"name":"Department of Immunology, Erasmus MC, University Medical Center Rotterdam, and MS Centrum ErasMS, 3000 CA Rotterdam, the Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rashed M.","family":"Nagra","sequence":"additional","affiliation":[{"name":"Neurology Research, West Los Angeles VA Medical Center, Los Angeles, CA 90073, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alyssa","family":"Nylander","sequence":"additional","affiliation":[{"name":"Department of Neurology, Yale School of Medicine, New Haven, CT 06511, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Pitt","sequence":"additional","affiliation":[{"name":"Department of Neurology, Yale School of Medicine, New Haven, CT 06511, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sriram","family":"Ramanan","sequence":"additional","affiliation":[{"name":"Department of Neurology, Yale School of Medicine, New Haven, CT 06511, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bilal A.","family":"Siddiqui","sequence":"additional","affiliation":[{"name":"Department of Neurology, Yale School of Medicine, New Haven, CT 06511, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francois","family":"Vigneault","sequence":"additional","affiliation":[{"name":"Department of Genetics, Harvard Medical School, Boston, MA 02115, USA."},{"name":"AbVitro Incorporated, Boston, MA 02210, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven H.","family":"Kleinstein","sequence":"additional","affiliation":[{"name":"Department of Pathology, Yale School of Medicine, New Haven, CT 06511, USA."},{"name":"Interdepartmental Program in Computational Biology and Bioinformatics, Yale University, New Haven, CT 06511, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David A.","family":"Hafler","sequence":"additional","affiliation":[{"name":"Department of Neurology, Yale School of Medicine, New Haven, CT 06511, USA."},{"name":"Department of Immunobiology, Yale School of Medicine, New Haven, CT 06511, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin C.","family":"O\u2019Connor","sequence":"additional","affiliation":[{"name":"Department of Neurology, Yale School of Medicine, New Haven, CT 06511, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI58649"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-2776(08)00404-5"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1750-3639.2004.tb00049.x"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awr182"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1110740"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0801888"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0706383"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1222794"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-065X.2008.00646.x"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awq350"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/1531-8249(200006)47:6<707::AID-ANA3>3.0.CO;2-Q"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awm038"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.171.5.2725"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneuroim.2011.01.010"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI63842"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.24088"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00109-008-0421-4"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.169.10.5415"},{"key":"e_1_3_2_20_2","first-page":"409","article-title":"Macrophages, lymphocytes, and plasma cells in the perivascular compartment in chronic multiple sclerosis","volume":"38","author":"Prineas J. W.","year":"1978","unstructured":"Prineas J. W., Wright R. G., Macrophages, lymphocytes, and plasma cells in the perivascular compartment in chronic multiple sclerosis. Lab. Invest. 38, 409\u2013421 (1978).","journal-title":"Lab. Invest."},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI3568"},{"key":"e_1_3_2_22_2","doi-asserted-by":"crossref","first-page":"5133","DOI":"10.4049\/jimmunol.163.9.5133","article-title":"B cell repertoire diversity and clonal expansion in multiple sclerosis brain lesions","volume":"163","author":"Baranzini S. E.","year":"1999","unstructured":"Baranzini S. E., Jeong M. C., Butunoi C., Murray R. S., Bernard C. C., Oksenberg J. R., B cell repertoire diversity and clonal expansion in multiple sclerosis brain lesions. J. Immunol. 163, 5133\u20135144 (1999).","journal-title":"J. Immunol."},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1093\/neuonc\/not110"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0803424"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gks457"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneuroim.2008.04.031"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410430214"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.173.2.395"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awm214"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-07-294249"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm1714"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.21641"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneuroim.2007.03.002"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200737784"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm1344"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3182a43b48"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.178.1.547"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.174.5.2860"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.10685"},{"key":"e_1_3_2_40_2","doi-asserted-by":"crossref","first-page":"3496","DOI":"10.4049\/jimmunol.163.6.3496","article-title":"Cloning the antibody response in humans with inflammatory central nervous system disease: Analysis of the expressed IgG repertoire in subacute sclerosing panencephalitis brain reveals disease-relevant antibodies that recognize specific measles virus antigens","volume":"163","author":"Burgoon M. P.","year":"1999","unstructured":"Burgoon M. P., Owens G. P., Smith-Jensen T., Walker D., Gilden D. H., Cloning the antibody response in humans with inflammatory central nervous system disease: Analysis of the expressed IgG repertoire in subacute sclerosing panencephalitis brain reveals disease-relevant antibodies that recognize specific measles virus antigens. J. Immunol. 163, 3496\u20133502 (1999).","journal-title":"J. Immunol."},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2013.10.034"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201142108"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1177\/1352458511428465"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1177\/1352458512463483"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneurol.2011.971"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btu138"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-61779-842-9_32"},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.156.7.2642"},{"key":"e_1_3_2_49_2","doi-asserted-by":"publisher","DOI":"10.2307\/1934352"},{"key":"e_1_3_2_50_2","first-page":"164","article-title":"PHYLIP\u2014Phylogeny Inference Package (Version 3.2)","volume":"5","author":"Felsenstein J.","year":"1989","unstructured":"Felsenstein J., PHYLIP\u2014Phylogeny Inference Package (Version 3.2). Cladistics 5, 164\u2013166 (1989).","journal-title":"Cladistics"},{"key":"e_1_3_2_51_2","article-title":"The igraph software package for complex network research","volume":"1695","author":"Cs\u00e1rdi G.","year":"2006","unstructured":"Cs\u00e1rdi G., Nepusz T., The igraph software package for complex network research. InterJ. Complex Syst. 1695 (2006).","journal-title":"InterJ. Complex Syst."}],"container-title":["Science Translational Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/scitranslmed.3008879","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,16]],"date-time":"2024-01-16T13:37:57Z","timestamp":1705412277000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/scitranslmed.3008879"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,8,6]]},"references-count":50,"journal-issue":{"issue":"248","published-print":{"date-parts":[[2014,8,6]]}},"alternative-id":["10.1126\/scitranslmed.3008879"],"URL":"https:\/\/doi.org\/10.1126\/scitranslmed.3008879","relation":{},"ISSN":["1946-6234","1946-6242"],"issn-type":[{"value":"1946-6234","type":"print"},{"value":"1946-6242","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,8,6]]}}}