{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T22:58:09Z","timestamp":1789167489938,"version":"build-2803163510"},"reference-count":80,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"249","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sci. Transl. Med."],"published-print":{"date-parts":[[2014,8,13]]},"abstract":"<jats:p>Infusion of lymph node\u2013derived fibroblastic reticular cells into septic mice increases survival at late time points after disease onset.<\/jats:p>","DOI":"10.1126\/scitranslmed.3009377","type":"journal-article","created":{"date-parts":[[2014,8,13]],"date-time":"2014-08-13T20:28:44Z","timestamp":1407961724000},"source":"Crossref","is-referenced-by-count":42,"title":["Lymph node fibroblastic reticular cell transplants show robust therapeutic efficacy in high-mortality murine sepsis"],"prefix":"10.1126","volume":"6","author":[{"given":"Anne L.","family":"Fletcher","sequence":"first","affiliation":[{"name":"Department of Cancer Immunology and AIDS, Dana-Farber Cancer Institute, Boston, MA 02115, USA."},{"name":"Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA 02115, USA."},{"name":"Department of Anatomy and Developmental Biology, Monash University, Clayton, Victoria 3800, Australia."},{"name":"School of Immunity and Infection, University of Birmingham, Birmingham B15 2TT, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica S.","family":"Elman","sequence":"additional","affiliation":[{"name":"Center for Engineering in Medicine and Surgical Services, Massachusetts General Hospital, Harvard Medical School, and Shriners Hospitals for Children, Boston, MA 02114, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jillian","family":"Astarita","sequence":"additional","affiliation":[{"name":"Department of Cancer Immunology and AIDS, Dana-Farber Cancer Institute, Boston, MA 02115, USA."},{"name":"Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA 02115, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan","family":"Murray","sequence":"additional","affiliation":[{"name":"Center for Engineering in Medicine and Surgical Services, Massachusetts General Hospital, Harvard Medical School, and Shriners Hospitals for Children, Boston, MA 02114, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nima","family":"Saeidi","sequence":"additional","affiliation":[{"name":"Center for Engineering in Medicine and Surgical Services, Massachusetts General Hospital, Harvard Medical School, and Shriners Hospitals for Children, Boston, MA 02114, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua","family":"D\u2019Rozario","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Developmental Biology, Monash University, Clayton, Victoria 3800, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konstantin","family":"Knoblich","sequence":"additional","affiliation":[{"name":"Department of Cancer Immunology and AIDS, Dana-Farber Cancer Institute, Boston, MA 02115, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Flavian D.","family":"Brown","sequence":"additional","affiliation":[{"name":"Department of Cancer Immunology and AIDS, Dana-Farber Cancer Institute, Boston, MA 02115, USA."},{"name":"Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA 02115, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank A.","family":"Schildberg","sequence":"additional","affiliation":[{"name":"Department of Cancer Immunology and AIDS, Dana-Farber Cancer Institute, Boston, MA 02115, USA."},{"name":"Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA 02115, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janice M.","family":"Nieves","sequence":"additional","affiliation":[{"name":"Department of Cancer Immunology and AIDS, Dana-Farber Cancer Institute, Boston, MA 02115, USA."},{"name":"Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA 02115, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tracy S. P.","family":"Heng","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Developmental Biology, Monash University, Clayton, Victoria 3800, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard L.","family":"Boyd","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Developmental Biology, Monash University, Clayton, Victoria 3800, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shannon J.","family":"Turley","sequence":"additional","affiliation":[{"name":"Department of Cancer Immunology and AIDS, Dana-Farber Cancer Institute, Boston, MA 02115, USA."},{"name":"Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA 02115, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Biju","family":"Parekkadan","sequence":"additional","affiliation":[{"name":"Center for Engineering in Medicine and Surgical Services, Massachusetts General Hospital, Harvard Medical School, and Shriners Hospitals for Children, Boston, MA 02114, USA."},{"name":"Harvard Stem Cell Institute, Cambridge, MA 02138, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","first-page":"694","article-title":"Treatment of sepsis in the surgical intensive care unit","volume":"13","author":"Carney D. E.","year":"2011","unstructured":"Carney D. E., Matsushima K., Frankel H. L., Treatment of sepsis in the surgical intensive care unit. Isr. Med. Assoc. J. 13, 694\u2013699 (2011).","journal-title":"Isr. Med. Assoc. J."},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkq515"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-200107000-00002"},{"key":"e_1_3_2_5_2","unstructured":"M. J. Hall S. N. Williams C. J. DeFrances M. S. Golosinskiy Inpatient Care for Septicemia or Sepsis: A Challenge for Patients and Hospitals (National Center for Health Statistics Hyattsville MD 2011)."},{"key":"e_1_3_2_6_2","unstructured":"J. Ferlay H. R. Shin F. Bray D. Forman C. Mathers D. M. Parkin GLOBOCAN 2008 v.2.0. Cancer Incidence and Mortality Worldwide: IARC CancerBase No. 10; http:\/\/globocan.iarc.fr."},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1159\/000329238"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrd1854"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1006\/cyto.2001.0932"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature01326"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3000678"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI39421"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.3810\/hp.2011.08.585"},{"key":"e_1_3_2_14_2","first-page":"CD004388","article-title":"Human recombinant activated protein C for severe sepsis","volume":"3","author":"Mart\u00ed-Carvajal A. J.","year":"2012","unstructured":"Mart\u00ed-Carvajal A. J., Sol\u00e0 I., Lathyris D., Cardona A. F., Human recombinant activated protein C for severe sepsis. Cochrane Database Syst. Rev. 3, CD004388 (2012).","journal-title":"Cochrane Database Syst. Rev."},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1258\/0007142991902222"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvq317"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1465-3249(05)70787-8"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2009.06.013"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.2174\/156652412800619950"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2006.10.011"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0702579104"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2010.11.002"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.imlet.2011.02.006"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni.2262"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2012.05.022"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2013.03.012"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri2832"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20092642"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1080\/14653240600855905"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.0908520"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm.1905"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1006\/cyto.1996.0126"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1128\/cdli.2.5.549-553.1995"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.2174\/092986708784872393"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mad.2003.08.002"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1097\/00024382-200304000-00003"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0b013e3182591ebe"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1002\/stem.544"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature03104"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-199907000-00002"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.25.14541"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0041549"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni.2112"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0027618"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0026138"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrd3953"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.1097\/SHK.0b013e318225f6ae"},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00180.2011"},{"key":"e_1_3_2_49_2","doi-asserted-by":"publisher","DOI":"10.1186\/1479-5876-10-244"},{"key":"e_1_3_2_50_2","doi-asserted-by":"publisher","DOI":"10.7150\/ijms.5385"},{"key":"e_1_3_2_51_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201001-0010OC"},{"key":"e_1_3_2_52_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni1513"},{"key":"e_1_3_2_53_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni1427"},{"key":"e_1_3_2_54_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20092465"},{"key":"e_1_3_2_55_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0046506"},{"key":"e_1_3_2_56_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0014247"},{"key":"e_1_3_2_57_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.2009.04069.x"},{"key":"e_1_3_2_58_2","doi-asserted-by":"publisher","DOI":"10.1111\/imr.12023"},{"key":"e_1_3_2_59_2","doi-asserted-by":"publisher","DOI":"10.3109\/00365528709078589"},{"key":"e_1_3_2_60_2","doi-asserted-by":"publisher","DOI":"10.1513\/pats.200505-048BG"},{"key":"e_1_3_2_61_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.15.1.323"},{"key":"e_1_3_2_62_2","first-page":"RA27","article-title":"Tonal nitric oxide and health: Anti-bacterial and -viral actions and implications for HIV","volume":"8","author":"Benz D.","year":"2002","unstructured":"Benz D., Cadet P., Mantione K., Zhu W., Stefano G., Tonal nitric oxide and health: Anti-bacterial and -viral actions and implications for HIV. Med. Sci. Monit. 8, RA27\u2013RA31 (2002).","journal-title":"Med. Sci. Monit."},{"key":"e_1_3_2_63_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro1004"},{"key":"e_1_3_2_64_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI72058"},{"key":"e_1_3_2_65_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00424-009-0773-9"},{"key":"e_1_3_2_66_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20091236"},{"key":"e_1_3_2_67_2","doi-asserted-by":"publisher","DOI":"10.1186\/cc12538"},{"key":"e_1_3_2_68_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(02)11393-6"},{"key":"e_1_3_2_69_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.CCM.0000105581.01815.C6"},{"key":"e_1_3_2_70_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2010.12.039"},{"key":"e_1_3_2_71_2","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2013-205124.191"},{"key":"e_1_3_2_72_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI45157"},{"key":"e_1_3_2_73_2","doi-asserted-by":"publisher","DOI":"10.1002\/stem.118"},{"key":"e_1_3_2_74_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellimm.2010.06.006"},{"key":"e_1_3_2_75_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1222878110"},{"key":"e_1_3_2_76_2","doi-asserted-by":"publisher","DOI":"10.1097\/SHK.0000000000000153"},{"key":"e_1_3_2_77_2","doi-asserted-by":"publisher","DOI":"10.1086\/427876"},{"key":"e_1_3_2_78_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-013-1971-0"},{"key":"e_1_3_2_79_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(07)70265-7"},{"key":"e_1_3_2_80_2","doi-asserted-by":"publisher","DOI":"10.1038\/mt.2011.192"},{"key":"e_1_3_2_81_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.177.4.1205"}],"container-title":["Science Translational Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/scitranslmed.3009377","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,16]],"date-time":"2024-01-16T18:37:38Z","timestamp":1705430258000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/scitranslmed.3009377"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,8,13]]},"references-count":80,"journal-issue":{"issue":"249","published-print":{"date-parts":[[2014,8,13]]}},"alternative-id":["10.1126\/scitranslmed.3009377"],"URL":"https:\/\/doi.org\/10.1126\/scitranslmed.3009377","relation":{},"ISSN":["1946-6234","1946-6242"],"issn-type":[{"value":"1946-6234","type":"print"},{"value":"1946-6242","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,8,13]]}}}