{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T16:31:17Z","timestamp":1781022677977,"version":"3.54.1"},"reference-count":30,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"257","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sci. Transl. Med."],"published-print":{"date-parts":[[2014,10,8]]},"abstract":"<jats:p>The \u03b1<jats:sub>2A<\/jats:sub>-adrenergic receptor antagonist yohimbine improves insulin secretion in type 2 diabetics carrying the<jats:italic>ADRA2A<\/jats:italic>risk variant.<\/jats:p>","DOI":"10.1126\/scitranslmed.3009934","type":"journal-article","created":{"date-parts":[[2014,10,8]],"date-time":"2014-10-08T18:14:46Z","timestamp":1412792086000},"source":"Crossref","is-referenced-by-count":66,"title":["Genotype-based treatment of type 2 diabetes with an \u03b1<sub>2A<\/sub>-adrenergic receptor antagonist"],"prefix":"10.1126","volume":"6","author":[{"given":"Yunzhao","family":"Tang","sequence":"first","affiliation":[{"name":"Department of Clinical Sciences, Lund University, SE-20502 Malm\u00f6, Sweden."},{"name":"2011 Collaborative Innovation Center of Tianjin for Medical Epigenetics (Ministry of Health), Key Laboratory of Hormones and Development, Metabolic Diseases Hospital &amp; Tianjin Institute of Endocrinology, Tianjin Medical University, Tianjin 300070, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annika S.","family":"Axelsson","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, Lund University, SE-20502 Malm\u00f6, Sweden."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Sp\u00e9gel","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, Lund University, SE-20502 Malm\u00f6, Sweden."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lotta E.","family":"Andersson","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, Lund University, SE-20502 Malm\u00f6, Sweden."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hindrik","family":"Mulder","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, Lund University, SE-20502 Malm\u00f6, Sweden."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leif C.","family":"Groop","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, Lund University, SE-20502 Malm\u00f6, Sweden."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erik","family":"Renstr\u00f6m","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, Lund University, SE-20502 Malm\u00f6, Sweden."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anders H.","family":"Rosengren","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, Lund University, SE-20502 Malm\u00f6, Sweden."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng.609"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2383"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2013.04.002"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature09792"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(14)70050-6"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.2217\/pgs.14.21"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1176827"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinbiochem.2013.02.004"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-011-2108-6"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0021464"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.2337\/db11-1516"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2156-10-23"},{"key":"e_1_3_2_14_2","unstructured":"M. Dukes Meyler\u2019s Side Effect of Drugs (Elsevier Amsterdam 2000) vol. 14 pp. 1024\u20131028."},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02455991"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.1994.tb04248.x"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3000606"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.50.8.1834"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2362.1988.tb01272.x"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1472-8206.1995.tb00292.x"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/55.1.219s"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.15.6.877"},{"key":"e_1_3_2_23_2","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1016\/S0022-3565(24)38219-9","article-title":"Adrenoceptors mediating the cardiovascular and metabolic effects of \u03b1-methylnoradrenaline in humans","volume":"289","author":"Sch\u00e4fers R. F.","year":"1999","unstructured":"Sch\u00e4fers R. F., N\u00fcrnberger J., Herrmann B., Wenzel R. R., Philipp T., Michel M. C., Adrenoceptors mediating the cardiovascular and metabolic effects of \u03b1-methylnoradrenaline in humans. J. Pharmacol. Exp. Ther. 289, 918\u2013925 (1999).","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.2337\/diab.36.8.932"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI108338"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-67-5-1054"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0898-6568(96)00096-4"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.2871625"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.273.5276.801"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.2337\/db12-0827"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2012.10.009"}],"container-title":["Science Translational Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/scitranslmed.3009934","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,5]],"date-time":"2025-05-05T02:18:05Z","timestamp":1746411485000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/scitranslmed.3009934"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,10,8]]},"references-count":30,"journal-issue":{"issue":"257","published-print":{"date-parts":[[2014,10,8]]}},"alternative-id":["10.1126\/scitranslmed.3009934"],"URL":"https:\/\/doi.org\/10.1126\/scitranslmed.3009934","relation":{},"ISSN":["1946-6234","1946-6242"],"issn-type":[{"value":"1946-6234","type":"print"},{"value":"1946-6242","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,10,8]]}}}