{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T01:22:50Z","timestamp":1792113770737,"version":"4.4.0"},"reference-count":39,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"287","license":[{"start":{"date-parts":[[2016,5,13]],"date-time":"2016-05-13T00:00:00Z","timestamp":1463097600000},"content-version":"vor","delay-in-days":366,"URL":"http:\/\/www.sciencemag.org\/about\/science-licenses-journal-article-reuse"}],"funder":[{"DOI":"10.13039\/100004328","name":"Genentech Inc.","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004328","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sci. Transl. Med."],"published-print":{"date-parts":[[2015,5,13]]},"abstract":"<jats:p>Anti-CD20\/CD3 T cell\u2013dependent bispecific antibodies may be useful for the treatment of B cell malignancies.<\/jats:p>","DOI":"10.1126\/scitranslmed.aaa4802","type":"journal-article","created":{"date-parts":[[2015,5,13]],"date-time":"2015-05-13T14:51:30Z","timestamp":1431528690000},"source":"Crossref","is-referenced-by-count":253,"title":["Anti-CD20\/CD3 T cell\u2013dependent bispecific antibody for the treatment of B cell malignancies"],"prefix":"10.1126","volume":"7","author":[{"given":"Liping L.","family":"Sun","sequence":"first","affiliation":[{"name":"Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diego","family":"Ellerman","sequence":"additional","affiliation":[{"name":"Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary","family":"Mathieu","sequence":"additional","affiliation":[{"name":"Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Hristopoulos","sequence":"additional","affiliation":[{"name":"Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaocheng","family":"Chen","sequence":"additional","affiliation":[{"name":"Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yijin","family":"Li","sequence":"additional","affiliation":[{"name":"Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaojie","family":"Yan","sequence":"additional","affiliation":[{"name":"The Feinstein Institute for Medical Research, Manhasset, NY 11030, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robyn","family":"Clark","sequence":"additional","affiliation":[{"name":"Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arthur","family":"Reyes","sequence":"additional","affiliation":[{"name":"Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Stefanich","sequence":"additional","affiliation":[{"name":"Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elaine","family":"Mai","sequence":"additional","affiliation":[{"name":"Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judy","family":"Young","sequence":"additional","affiliation":[{"name":"Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clarissa","family":"Johnson","sequence":"additional","affiliation":[{"name":"Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahrukh","family":"Huseni","sequence":"additional","affiliation":[{"name":"Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinhua","family":"Wang","sequence":"additional","affiliation":[{"name":"Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yvonne","family":"Chen","sequence":"additional","affiliation":[{"name":"Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peiyin","family":"Wang","sequence":"additional","affiliation":[{"name":"Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Wang","sequence":"additional","affiliation":[{"name":"Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noel","family":"Dybdal","sequence":"additional","affiliation":[{"name":"Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Waye","family":"Chu","sequence":"additional","affiliation":[{"name":"Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas","family":"Chiorazzi","sequence":"additional","affiliation":[{"name":"The Feinstein Institute for Medical Research, Manhasset, NY 11030, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justin M.","family":"Scheer","sequence":"additional","affiliation":[{"name":"Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teemu","family":"Junttila","sequence":"additional","affiliation":[{"name":"Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klara","family":"Totpal","sequence":"additional","affiliation":[{"name":"Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark S.","family":"Dennis","sequence":"additional","affiliation":[{"name":"Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allen J.","family":"Ebens","sequence":"additional","affiliation":[{"name":"Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.3322\/caac.20107"},{"key":"e_1_3_2_3_2","first-page":"CD008079","article-title":"Rituximab, ofatumumab and other monoclonal anti-CD20 antibodies for chronic lymphocytic leukaemia","volume":"11","author":"Bauer K.","year":"2012","unstructured":"Bauer K., Rancea M., Roloff V., Elter T., Hallek M., Engert A., Skoetz N., Rituximab, ofatumumab and other monoclonal anti-CD20 antibodies for chronic lymphocytic leukaemia. Cochrane Database Syst. Rev. 11, CD008079 (2012).","journal-title":"Cochrane Database Syst. Rev."},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1215134"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-10-384388"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2013-11-492231"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-07-441030"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2010.32.7270"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2012.07.013"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2013-02-485623"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-09-306449"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00262-012-1339-9"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.23626"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2012.04.020"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.2621"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-13-3622-T"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2005.07.034"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-04-2637"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.173.1.7"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.174.2.817"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-02-0516"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V98.12.3383"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V98.5.1326"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.seminhematol.2014.05.006"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-09-457531"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-02-411678"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI24176"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-12-324210"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.171.3.1581"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-07-168146"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni1058"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature01076"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(00)80483-5"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-09-380949"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-01-400515"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1158\/1535-7163.MCT-09-0369"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.170.8.4397"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0902874"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.13242"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1006\/jmbi.1997.1116"}],"container-title":["Science Translational Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/scitranslmed.aaa4802","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,16]],"date-time":"2024-01-16T13:21:30Z","timestamp":1705411290000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/scitranslmed.aaa4802"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,5,13]]},"references-count":39,"journal-issue":{"issue":"287","published-print":{"date-parts":[[2015,5,13]]}},"alternative-id":["10.1126\/scitranslmed.aaa4802"],"URL":"https:\/\/doi.org\/10.1126\/scitranslmed.aaa4802","relation":{},"ISSN":["1946-6234","1946-6242"],"issn-type":[{"value":"1946-6234","type":"print"},{"value":"1946-6242","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,5,13]]}}}