{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T18:35:12Z","timestamp":1791398112004,"version":"4.3.3"},"reference-count":52,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"287","license":[{"start":{"date-parts":[[2016,5,13]],"date-time":"2016-05-13T00:00:00Z","timestamp":1463097600000},"content-version":"vor","delay-in-days":366,"URL":"http:\/\/www.sciencemag.org\/about\/science-licenses-journal-article-reuse"}],"funder":[{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["P01 AI045757"],"award-info":[{"award-number":["P01 AI045757"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["U19 AI046130"],"award-info":[{"award-number":["U19 AI046130"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["U19 AI070352"],"award-info":[{"award-number":["U19 AI070352"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["P01 AI039671"],"award-info":[{"award-number":["P01 AI039671"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007253","name":"Nancy Taylor Foundation for Chronic Diseases Inc.","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007253","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Koch Institute Support","award":["P30-CA14051"],"award-info":[{"award-number":["P30-CA14051"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sci. Transl. Med."],"published-print":{"date-parts":[[2015,5,13]]},"abstract":"<jats:p>\n                    CCR6\n                    <jats:sup>+<\/jats:sup>\n                    myelin-reactive T cells from patients with multiple sclerosis secrete inflammatory cytokines compared to T cells from healthy subjects, showing a distinct pathogenic gene expression profile and sharing a transcriptome homology with encephalitogenic CD4\n                    <jats:sup>+<\/jats:sup>\n                    T cells isolated from mice with experimental autoimmune encephalitis.\n                  <\/jats:p>","DOI":"10.1126\/scitranslmed.aaa8038","type":"journal-article","created":{"date-parts":[[2015,5,13]],"date-time":"2015-05-13T14:51:30Z","timestamp":1431528690000},"source":"Crossref","is-referenced-by-count":269,"title":["Functional inflammatory profiles distinguish myelin-reactive T cells from patients with multiple sclerosis"],"prefix":"10.1126","volume":"7","author":[{"given":"Yonghao","family":"Cao","sequence":"first","affiliation":[{"name":"Departments of Neurology and Immunobiology, Yale School of Medicine, New Haven, CT 06520, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brittany A.","family":"Goods","sequence":"additional","affiliation":[{"name":"Department of Biological Engineering, Koch Institute for Integrative Cancer Research at Massachusetts Institute of Technology (MIT), Cambridge, MA 02139, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khadir","family":"Raddassi","sequence":"additional","affiliation":[{"name":"Departments of Neurology and Immunobiology, Yale School of Medicine, New Haven, CT 06520, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerald T.","family":"Nepom","sequence":"additional","affiliation":[{"name":"Benaroya Research Institute, Virginia Mason Research Center, Seattle, WA 98101, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William W.","family":"Kwok","sequence":"additional","affiliation":[{"name":"Benaroya Research Institute, Virginia Mason Research Center, Seattle, WA 98101, USA."},{"name":"Department of Medicine, University of Washington, Seattle, WA 98101, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. Christopher","family":"Love","sequence":"additional","affiliation":[{"name":"Department of Chemical Engineering, Koch Institute for Integrative Cancer Research at MIT, Cambridge, MA 02139, USA."},{"name":"The Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David A.","family":"Hafler","sequence":"additional","affiliation":[{"name":"Departments of Neurology and Immunobiology, Yale School of Medicine, New Haven, CT 06520, USA."},{"name":"The Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni1507"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri2550"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI58649"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa073493"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature10251"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrg3502"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature13835"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.58.1.39"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/346183a0"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.173.1.19"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1001543"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20031819"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature09447"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni.2031"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni.2027"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni.2416"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.2337\/db09-1168"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/9780470697405.ch16"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI29251"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20090504"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni.1716"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0713169"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneuroim.2013.02.002"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni.1770"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20091021"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-065X.1998.tb01211.x"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm1202"},{"key":"e_1_3_2_29_2","doi-asserted-by":"crossref","first-page":"982","DOI":"10.4049\/jimmunol.155.2.982","article-title":"T cell recognition of immunodominant and cryptic proteolipid protein epitopes in humans","volume":"155","author":"Markovic-Plese S.","year":"1995","unstructured":"Markovic-Plese S., Fukaura H., Zhang J., al-Sabbagh A., Southwood S., Sette A., Kuchroo V. K., Hafler D. A., T cell recognition of immunodominant and cryptic proteolipid protein epitopes in humans. J. Immunol. 155, 982\u2013992 (1995).","journal-title":"J. Immunol."},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.172.6.3893"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature10957"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awp289"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(12)70003-0"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0909307106"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri2138"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2011.01.020"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0506580102"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0086643"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2011.08.007"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2012.09.016"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20130301"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri2711"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3004186"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI72973"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2011.10.015"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.1038\/icb.2013.55"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/659206"},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.1038\/cr.2014.154"},{"key":"e_1_3_2_49_2","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3008706"},{"key":"e_1_3_2_50_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awl075"},{"key":"e_1_3_2_51_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMe020157"},{"key":"e_1_3_2_52_2","first-page":"342","article-title":"Systematic method for determining an ideal housekeeping gene for real-time PCR analysis","volume":"19","author":"Mane V. P.","year":"2008","unstructured":"Mane V. P., Heuer M. A., Hillyer P., Navarro M. B., Rabin R. L., Systematic method for determining an ideal housekeeping gene for real-time PCR analysis. J. Biomol. Tech. 19, 342\u2013347 (2008).","journal-title":"J. Biomol. Tech."},{"key":"e_1_3_2_53_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2164-7-115"}],"container-title":["Science Translational Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/scitranslmed.aaa8038","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,16]],"date-time":"2024-01-16T13:21:33Z","timestamp":1705411293000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/scitranslmed.aaa8038"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,5,13]]},"references-count":52,"journal-issue":{"issue":"287","published-print":{"date-parts":[[2015,5,13]]}},"alternative-id":["10.1126\/scitranslmed.aaa8038"],"URL":"https:\/\/doi.org\/10.1126\/scitranslmed.aaa8038","relation":{},"ISSN":["1946-6234","1946-6242"],"issn-type":[{"value":"1946-6234","type":"print"},{"value":"1946-6242","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,5,13]]}}}