{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T13:42:10Z","timestamp":1790862130567,"version":"4.1.0"},"reference-count":42,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"308","license":[{"start":{"date-parts":[[2016,10,7]],"date-time":"2016-10-07T00:00:00Z","timestamp":1475798400000},"content-version":"vor","delay-in-days":366,"URL":"http:\/\/www.sciencemag.org\/about\/science-licenses-journal-article-reuse"}],"funder":[{"DOI":"10.13039\/100000054","name":"NIH\/NCI (National Cancer Institute)","doi-asserted-by":"publisher","award":["CA9368305"],"award-info":[{"award-number":["CA9368305"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"NIAID (National Institute of Allergy and Infectious Diseases)","doi-asserted-by":"publisher","award":["R01 AI097128"],"award-info":[{"award-number":["R01 AI097128"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"NIAID (National Institute of Allergy and Infectious Diseases)","doi-asserted-by":"publisher","award":["T32 AR-07098-36"],"award-info":[{"award-number":["T32 AR-07098-36"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000069","name":"NIH\/NIAMS (National Institute of Arthritis and Musculoskeletal and Skin Diseases)","doi-asserted-by":"publisher","award":["R01 AR063962"],"award-info":[{"award-number":["R01 AR063962"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000069","name":"NIH\/NIAMS","doi-asserted-by":"publisher","award":["R01 AR056720"],"award-info":[{"award-number":["R01 AR056720"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005189","name":"Leukemia and Lymphoma Society","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005189","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Damon Runyon Clinical Investigator Award"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sci. Transl. Med."],"published-print":{"date-parts":[[2015,10,7]]},"abstract":"<jats:p>High-throughput TCR sequencing can accurately diagnose and discriminate CTCL cells in skin.<\/jats:p>","DOI":"10.1126\/scitranslmed.aaa9122","type":"journal-article","created":{"date-parts":[[2015,10,7]],"date-time":"2015-10-07T17:46:30Z","timestamp":1444239990000},"source":"Crossref","is-referenced-by-count":205,"title":["TCR sequencing facilitates diagnosis and identifies mature T cells as the cell of origin in CTCL"],"prefix":"10.1126","volume":"7","author":[{"given":"Ilan R.","family":"Kirsch","sequence":"first","affiliation":[{"name":"Adaptive Biotechnologies, Seattle, WA 98102, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rei","family":"Watanabe","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Brigham and Women\u2019s Hospital, Harvard Medical School, Boston, MA 02115, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John T.","family":"O\u2019Malley","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Brigham and Women\u2019s Hospital, Harvard Medical School, Boston, MA 02115, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David W.","family":"Williamson","sequence":"additional","affiliation":[{"name":"Adaptive Biotechnologies, Seattle, WA 98102, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura-Louise","family":"Scott","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Brigham and Women\u2019s Hospital, Harvard Medical School, Boston, MA 02115, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher P.","family":"Elco","sequence":"additional","affiliation":[{"name":"Department of Pathology, Brigham and Women\u2019s Hospital, Harvard Medical School, Boston, MA 02115, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica E.","family":"Teague","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Brigham and Women\u2019s Hospital, Harvard Medical School, Boston, MA 02115, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed","family":"Gehad","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Brigham and Women\u2019s Hospital, Harvard Medical School, Boston, MA 02115, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth L.","family":"Lowry","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Brigham and Women\u2019s Hospital, Harvard Medical School, Boston, MA 02115, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole R.","family":"LeBoeuf","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Brigham and Women\u2019s Hospital, Harvard Medical School, Boston, MA 02115, USA."},{"name":"Dana-Farber\/Brigham and Women\u2019s Cancer Center, Boston, MA 02115, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James G.","family":"Krueger","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Rockefeller University, New York, NY 10065, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harlan S.","family":"Robins","sequence":"additional","affiliation":[{"name":"Adaptive Biotechnologies, Seattle, WA 98102, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas S.","family":"Kupper","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Brigham and Women\u2019s Hospital, Harvard Medical School, Boston, MA 02115, USA."},{"name":"Dana-Farber\/Brigham and Women\u2019s Cancer Center, Boston, MA 02115, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachael A.","family":"Clark","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Brigham and Women\u2019s Hospital, Harvard Medical School, Boston, MA 02115, USA."},{"name":"Dana-Farber\/Brigham and Women\u2019s Cancer Center, Boston, MA 02115, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-09-3502"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.139.7.857"},{"key":"e_1_3_2_4_2","unstructured":"NCCN Guidelines \u00ae (National Comprehensive Cancer Network Inc. Fort Washington PA 2009); www.NCCN.org."},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(94)70231-4"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2403202"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jid.5701109"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.136.4.504"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-04-217604"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3007420"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2015.04.030"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.138.8.1063"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.136.12.1483"},{"key":"e_1_3_2_14_2","first-page":"417","article-title":"Clonal T-cell populations in pityriasis lichenoides et varioliformis acuta (Mucha-Habermann disease)","volume":"126","author":"Weiss L. M.","year":"1987","unstructured":"Weiss L. M., Wood G. S., Ellisen L. W., Reynolds T. C., Sklar J., Clonal T-cell populations in pityriasis lichenoides et varioliformis acuta (Mucha-Habermann disease). Am. J. Pathol. 126, 417\u2013421 (1987).","journal-title":"Am. J. Pathol."},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3002536"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3003008"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/imr.12140"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-11-251926"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20061792"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature12110"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3010302"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.0022-202X.2004.22303.x"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.2006.00507.x"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.169.4.1984"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.0022-202x.2001.01548.x"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.168.7.3649"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri853"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.smim.2005.02.007"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.8178155"},{"key":"e_1_3_2_30_2","doi-asserted-by":"crossref","first-page":"4492","DOI":"10.4049\/jimmunol.155.9.4492","article-title":"Ultraviolet B radiation up-regulates the expression of IL-15 in human skin","volume":"155","author":"Mohamadzadeh M.","year":"1995","unstructured":"Mohamadzadeh M., Takashima A., Dougherty I., Knop J., Bergstresser P. R., Cruz P. D., Ultraviolet B radiation up-regulates the expression of IL-15 in human skin. J. Immunol. 155, 4492\u20134496 (1995).","journal-title":"J. Immunol."},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.2001.00239.x"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.194.8.1187"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-02-002873"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V92.1.252.413k08_252_258"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V98.9.2778"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-07-2403"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.3816\/CLM.2008.n.011"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0733-8635(18)30176-1"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2013.10099"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkn838"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1101\/pdb.top115"},{"key":"e_1_3_2_42_2","first-page":"27","article-title":"IMGT, The International ImMunoGeneTics Information System, http:\/\/imgt.cines.fr","volume":"248","author":"Lefranc M. P.","year":"2004","unstructured":"Lefranc M. P., IMGT, The International ImMunoGeneTics Information System, http:\/\/imgt.cines.fr. Methods Mol. Biol. 248, 27\u201349 (2004).","journal-title":"Methods Mol. Biol."},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms3680"}],"container-title":["Science Translational Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/scitranslmed.aaa9122","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,16]],"date-time":"2024-01-16T13:06:37Z","timestamp":1705410397000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/scitranslmed.aaa9122"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,10,7]]},"references-count":42,"journal-issue":{"issue":"308","published-print":{"date-parts":[[2015,10,7]]}},"alternative-id":["10.1126\/scitranslmed.aaa9122"],"URL":"https:\/\/doi.org\/10.1126\/scitranslmed.aaa9122","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.725839869.793521215","asserted-by":"object"}]},"ISSN":["1946-6234","1946-6242"],"issn-type":[{"value":"1946-6234","type":"print"},{"value":"1946-6242","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,10,7]]}}}