{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T22:24:48Z","timestamp":1790375088888,"version":"4.1.0"},"reference-count":82,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"293","license":[{"start":{"date-parts":[[2016,6,24]],"date-time":"2016-06-24T00:00:00Z","timestamp":1466726400000},"content-version":"vor","delay-in-days":366,"URL":"http:\/\/www.sciencemag.org\/about\/science-licenses-journal-article-reuse"}],"funder":[{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["R01GM099530"],"award-info":[{"award-number":["R01GM099530"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","award":["UH2AR057503"],"award-info":[{"award-number":["UH2AR057503"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sci. Transl. Med."],"published-print":{"date-parts":[[2015,6,24]]},"abstract":"<jats:p>\n                    Vitamin B\n                    <jats:sub>12<\/jats:sub>\n                    modulates the transcriptional activities of the skin microbiota, leading to acne development.\n                  <\/jats:p>","DOI":"10.1126\/scitranslmed.aab2009","type":"journal-article","created":{"date-parts":[[2015,6,24]],"date-time":"2015-06-24T14:33:02Z","timestamp":1435156382000},"source":"Crossref","is-referenced-by-count":167,"title":["Vitamin B\n                    <sub>12<\/sub>\n                    modulates the transcriptome of the skin microbiota in acne pathogenesis"],"prefix":"10.1126","volume":"7","author":[{"given":"Dezhi","family":"Kang","sequence":"first","affiliation":[{"name":"Department of Molecular and Medical Pharmacology, Crump Institute for Molecular Imaging, David Geffen School of Medicine, University of California, Los Angeles (UCLA), Los Angeles, CA 90095, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baochen","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Molecular and Medical Pharmacology, Crump Institute for Molecular Imaging, David Geffen School of Medicine, University of California, Los Angeles (UCLA), Los Angeles, CA 90095, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie C.","family":"Erfe","sequence":"additional","affiliation":[{"name":"Los Angeles Biomedical Research Institute at Harbor\u2013UCLA Medical Center, Torrance, CA 90502, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noah","family":"Craft","sequence":"additional","affiliation":[{"name":"Los Angeles Biomedical Research Institute at Harbor\u2013UCLA Medical Center, Torrance, CA 90502, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiying","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Molecular and Medical Pharmacology, Crump Institute for Molecular Imaging, David Geffen School of Medicine, University of California, Los Angeles (UCLA), Los Angeles, CA 90095, USA."},{"name":"UCLA\u2013Department of Energy (DOE) Institute for Genomics and Proteomics, Los Angeles, CA 90095, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature11234"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2013.21"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1171700"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrg3182"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-pathol-011811-132421"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12676718"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12607634"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.1978.tb01496.x"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.1.6171.1109"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2009.47"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.1998.02511.x"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2010.264"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-200363150-00005"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1080\/00015550310016463"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/0190-9622(95)90243-0"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(11)60321-8"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.00003-13"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1100330"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1186\/gb-2003-4-5-p3"},{"key":"e_1_3_2_21_2","first-page":"349","article-title":"Vitamine B12 et pouss\u00e9e aen\u00e9\u00efforme","volume":"116","author":"Jadassohn W.","year":"1958","unstructured":"Jadassohn W., Paillard R., Hofer R., Golaz M., Vitamine B12 et pouss\u00e9e aen\u00e9\u00efforme. Dermatologica 116, 349 (1958).","journal-title":"Dermatologica"},{"key":"e_1_3_2_22_2","first-page":"813","article-title":"A new iatrogenic dermatosis: Acne caused by vitamin B 12","volume":"74","author":"Puissant A.","year":"1967","unstructured":"Puissant A., Vanbremeersch F., Monfort J., Lamberton J. N., A new iatrogenic dermatosis: Acne caused by vitamin B 12. Bull. Soc. Fr. Dermatol. Syphiligr. 74, 813\u2013815 (1967).","journal-title":"Bull. Soc. Fr. Dermatol. Syphiligr."},{"key":"e_1_3_2_23_2","first-page":"1165","article-title":"Acne caused by vitamin B 12","volume":"221","author":"Dugois P.","year":"1969","unstructured":"Dugois P., Amblard P., Imbert R., de Bignicourt B., Acne caused by vitamin B 12. Lyon Med. 221, 1165 (1969).","journal-title":"Lyon Med."},{"key":"e_1_3_2_24_2","first-page":"155","article-title":"The problem of vitamin B6\/B12 acne. A contribution on acne medicamentosa (author\u2019s transl)","volume":"118","author":"Braun-Falco O.","year":"1976","unstructured":"Braun-Falco O., Lincke H., The problem of vitamin B6\/B12 acne. A contribution on acne medicamentosa (author\u2019s transl). MMW Munch. Med. Wochenschr. 118, 155\u2013160 (1976).","journal-title":"MMW Munch. Med. Wochenschr."},{"key":"e_1_3_2_25_2","first-page":"210","article-title":"Vitamin B-12 induced acnes","volume":"24","author":"Dupr\u00e9 A.","year":"1979","unstructured":"Dupr\u00e9 A., Albarel N., Bonafe J., Christol B., Lassere J., Vitamin B-12 induced acnes. Cutis 24, 210 (1979).","journal-title":"Cutis"},{"key":"e_1_3_2_26_2","first-page":"119","article-title":"Acneiform eruption due to \u201cmegadose\u201d vitamins B6 and B12","volume":"48","author":"Sherertz E.","year":"1991","unstructured":"Sherertz E., Acneiform eruption due to \u201cmegadose\u201d vitamins B6 and B12. Cutis 48, 119\u2013120 (1991).","journal-title":"Cutis"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.3109\/15569527.2013.808657"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1039\/b108967f"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2958.1997.1761543.x"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.180.24.6719-6728.1998"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1261\/rna.5710303"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V18.5.511.511"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/10.6.480"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.0954-6820.1966.tb02812.x"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1969.tb15973.x"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1128\/aem.59.1.347-350.1993"},{"key":"e_1_3_2_37_2","first-page":"232","article-title":"Possible competition in the use of delta-aminolevulinic acid for the biosynthesis of vitamin B 12 and porphyrin by resting suspensions of Propionibacterium shermanii","volume":"180","author":"Bykhovski\u012d V.","year":"1968","unstructured":"Bykhovski\u012d V., Za\u012dtseva N. I., Bukin V. N., Possible competition in the use of delta-aminolevulinic acid for the biosynthesis of vitamin B 12 and porphyrin by resting suspensions of Propionibacterium shermanii. Dokl. Akad. Nauk SSSR 180, 232\u2013234 (1968).","journal-title":"Dokl. Akad. Nauk SSSR"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.mi.24.100170.001111"},{"key":"e_1_3_2_39_2","first-page":"1476","article-title":"Regulation of vitamin B-12 and prophyrin biosynthesis in Propionibacterium shermanii","volume":"190","author":"Za\u012dtseva N. I.","year":"1970","unstructured":"Za\u012dtseva N. I., Bykhovski\u012d V., Bukin V. N., Regulation of vitamin B-12 and prophyrin biosynthesis in Propionibacterium shermanii. Dokl. Akad. Nauk SSSR 190, 1476\u20131479 (1970).","journal-title":"Dokl. Akad. Nauk SSSR"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1986.tb04060.x"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2672.1994.tb04405.x"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2005.06530.x"},{"key":"e_1_3_2_43_2","first-page":"106","article-title":"Vitamin B-12 levels in blood serum in acne-like skin diseases","volume":"17","author":"Goldblatt S.","year":"1966","unstructured":"Goldblatt S., Vitamin B-12 levels in blood serum in acne-like skin diseases. Hautarzt 17, 106\u2013108 (1966).","journal-title":"Hautarzt"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2011.05027.x"},{"key":"e_1_3_2_45_2","first-page":"758","article-title":"Cutaneous porphyrin fluorescence as an indicator of antibiotic absorption and effectiveness","volume":"12","author":"Martin R. J.","year":"1973","unstructured":"Martin R. J., Kahn G., Gooding J. W., Brown G., Cutaneous porphyrin fluorescence as an indicator of antibiotic absorption and effectiveness. Cutis 12, 758\u2013764 (1973).","journal-title":"Cutis"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4362.1986.tb04534.x"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-0088"},{"key":"e_1_3_2_48_2","first-page":"139","article-title":"Efficacy of octenidine dihydrochloride and 2-phenoxyethanol in the topical treatment of inflammatory acne","volume":"17","author":"Mayr-Kanh\u00e4user S.","year":"2008","unstructured":"Mayr-Kanh\u00e4user S., Kr\u00e4nke B., Aberer W., Efficacy of octenidine dihydrochloride and 2-phenoxyethanol in the topical treatment of inflammatory acne. Acta Dermatovenerol. Alp. Panonica Adriat. 17, 139\u2013143 (2008).","journal-title":"Acta Dermatovenerol. Alp. Panonica Adriat."},{"key":"e_1_3_2_49_2","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(84)90606-1"},{"key":"e_1_3_2_50_2","doi-asserted-by":"publisher","DOI":"10.1099\/jmm.0.46118-0"},{"key":"e_1_3_2_51_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201104-0655OC"},{"key":"e_1_3_2_52_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00248-011-9813-z"},{"key":"e_1_3_2_53_2","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12468965"},{"key":"e_1_3_2_54_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro2537"},{"key":"e_1_3_2_55_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature11552"},{"key":"e_1_3_2_56_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature11400"},{"key":"e_1_3_2_57_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature12820"},{"key":"e_1_3_2_58_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1235872"},{"key":"e_1_3_2_59_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1208344"},{"key":"e_1_3_2_60_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature12721"},{"key":"e_1_3_2_61_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature09922"},{"key":"e_1_3_2_62_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature12347"},{"key":"e_1_3_2_63_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2009.08.003"},{"key":"e_1_3_2_64_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2010.03685.x"},{"key":"e_1_3_2_65_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature11209"},{"key":"e_1_3_2_66_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gks1219"},{"key":"e_1_3_2_67_2","doi-asserted-by":"publisher","DOI":"10.1186\/gb-2009-10-3-r25"},{"key":"e_1_3_2_68_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1000071108"},{"key":"e_1_3_2_69_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/17.3.282"},{"key":"e_1_3_2_70_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature08756"},{"key":"e_1_3_2_71_2","doi-asserted-by":"publisher","DOI":"10.1128\/jb.171.1.154-161.1989"},{"key":"e_1_3_2_72_2","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1542\/peds.51.2.254","article-title":"The FEP (free erythrocyte porphyrins) test: A screening micromethod for lead poisoning","volume":"51","author":"Piomelli S.","year":"1973","unstructured":"Piomelli S., Davidow B., Guinee V. F., Young P., Gay G., The FEP (free erythrocyte porphyrins) test: A screening micromethod for lead poisoning. Pediatrics 51, 254\u2013259 (1973).","journal-title":"Pediatrics"},{"key":"e_1_3_2_73_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btp508"},{"key":"e_1_3_2_74_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btl117"},{"key":"e_1_3_2_75_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0708897105"},{"key":"e_1_3_2_76_2","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.71.7.4121-4126.2005"},{"key":"e_1_3_2_77_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2105-4-41"},{"key":"e_1_3_2_78_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkr988"},{"key":"e_1_3_2_79_2","unstructured":"J. Oksanen F. G. Blanchet R. Kindt P. Legendre R. G. O\u2019Hara G. L. Simpson P. Solymos M. Henry H. Stevens H. Wagner vegan: Community ecology package. R package version 1.17-0 (2010); http:\/\/cran.r-project.org\/web\/packages\/vegan\/."},{"key":"e_1_3_2_80_2","unstructured":"B. Bolker L. Bonebakker R. Gentleman W. H. A. Liaw T. Lumley M. Maechler A. Magnusson S. Moeller M. Schwartz B. Venables gplots: Various R programming tools for plotting data. R package version 2.7.4 (2009); http:\/\/cran.r-project.org\/web\/packages\/gplots\/."},{"key":"e_1_3_2_81_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0019350"},{"key":"e_1_3_2_82_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkr313"},{"key":"e_1_3_2_83_2","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/918320"}],"container-title":["Science Translational Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/scitranslmed.aab2009","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,16]],"date-time":"2024-01-16T13:47:34Z","timestamp":1705412854000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/scitranslmed.aab2009"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,6,24]]},"references-count":82,"journal-issue":{"issue":"293","published-print":{"date-parts":[[2015,6,24]]}},"alternative-id":["10.1126\/scitranslmed.aab2009"],"URL":"https:\/\/doi.org\/10.1126\/scitranslmed.aab2009","relation":{},"ISSN":["1946-6234","1946-6242"],"issn-type":[{"value":"1946-6234","type":"print"},{"value":"1946-6242","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,6,24]]}}}