{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T00:37:30Z","timestamp":1789951050870,"version":"4.0.1"},"reference-count":41,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"307","license":[{"start":{"date-parts":[[2016,9,30]],"date-time":"2016-09-30T00:00:00Z","timestamp":1475193600000},"content-version":"vor","delay-in-days":366,"URL":"http:\/\/www.sciencemag.org\/about\/science-licenses-journal-article-reuse"}],"funder":[{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["DE015254"],"award-info":[{"award-number":["DE015254"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["DE021685"],"award-info":[{"award-number":["DE021685"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["DE024716"],"award-info":[{"award-number":["DE024716"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["AI068730"],"award-info":[{"award-number":["AI068730"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000781","name":"European Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000781","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["CH279\/5-1"],"award-info":[{"award-number":["CH279\/5-1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["SFB-TR127 Project-A3"],"award-info":[{"award-number":["SFB-TR127 Project-A3"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"name":"NIH\/National Institute of Dental"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sci. Transl. Med."],"published-print":{"date-parts":[[2015,9,30]]},"abstract":"<jats:p>Developmental endothelial locus\u20131 (DEL-1) is an endogenous homeostatic regulator of osteoclasts that blocks inflammatory bone loss in nonhuman primates.<\/jats:p>","DOI":"10.1126\/scitranslmed.aac5380","type":"journal-article","created":{"date-parts":[[2015,9,30]],"date-time":"2015-09-30T18:33:43Z","timestamp":1443638023000},"source":"Crossref","is-referenced-by-count":107,"title":["DEL-1 restrains osteoclastogenesis and inhibits inflammatory bone loss in nonhuman primates"],"prefix":"10.1126","volume":"7","author":[{"given":"Jieun","family":"Shin","sequence":"first","affiliation":[{"name":"Department of Microbiology, Penn Dental Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoki","family":"Maekawa","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Penn Dental Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshiharu","family":"Abe","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Penn Dental Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evlambia","family":"Hajishengallis","sequence":"additional","affiliation":[{"name":"Department of Preventive and Restorative Sciences, Division of Pediatric Dentistry, Penn Dental Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kavita","family":"Hosur","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Penn Dental Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kalyani","family":"Pyaram","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Penn Dental Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ioannis","family":"Mitroulis","sequence":"additional","affiliation":[{"name":"Department of Clinical Pathobiochemistry, Institute for Clinical Chemistry and Laboratory Medicine, Technische Universit\u00e4t Dresden, 01307 Dresden, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Triantafyllos","family":"Chavakis","sequence":"additional","affiliation":[{"name":"Department of Clinical Pathobiochemistry, Institute for Clinical Chemistry and Laboratory Medicine, Technische Universit\u00e4t Dresden, 01307 Dresden, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"Hajishengallis","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Penn Dental Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri3785"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2014.11.004"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1177\/0022034512457373"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0757.2010.00360.x"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni.2260"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1165218"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2014.146"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1101\/gad.12.1.21"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.111.068833"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2014.02.009"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2014.11.008"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00441-007-0456-9"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.172.6.3876"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1160\/TH13-09-0794"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneuroim.2003.08.013"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2013.19"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng.1005"},{"key":"e_1_3_2_19_2","article-title":"Neutrophil homeostasis and inflammation: Novel paradigms from studying periodontitis","author":"Hajishengallis G.","year":"2014","unstructured":"Hajishengallis G., Chavakis T., Hajishengallis E., Lambris J. D., Neutrophil homeostasis and inflammation: Novel paradigms from studying periodontitis. J. Leukoc. Biol. 10.1189\/jlb.3VMR1014-468R (2014).","journal-title":"J. Leukoc. Biol."},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.1739"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00774-007-0773-9"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1400970"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2011.01810.x"},{"key":"e_1_3_2_24_2","unstructured":"R. C. Page H. E. Schroeder Periodontitis in Man and Other Animals: A Comparative Review (Karger Basel 1982)."},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0463.2010.02706.x"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tem.2012.05.005"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrd3794"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.0105-2896.2005.00326.x"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-09-178301"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1222878110"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/617809"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexmp.2013.09.002"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1210\/en.2012-1617"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201108-1428CI"},{"key":"e_1_3_2_35_2","first-page":"55","article-title":"Enzyme replacement therapy for pancreatic insufficiency: Present and future","volume":"4","author":"Fieker A.","year":"2011","unstructured":"Fieker A., Philpott J., Armand M., Enzyme replacement therapy for pancreatic insufficiency: Present and future. Clin. Exp. Gastroenterol. 4, 55\u201373 (2011).","journal-title":"Clin. Exp. Gastroenterol."},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3005007"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1400569"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jim.2013.05.002"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1202339"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.0906-6713.2002.003421.x"},{"key":"e_1_3_2_41_2","first-page":"129","article-title":"Generating murine osteoclasts from bone marrow","volume":"80","author":"Takahashi N.","year":"2003","unstructured":"Takahashi N., Udagawa N., Tanaka S., Suda T., Generating murine osteoclasts from bone marrow. Methods Mol. Med. 80, 129\u2013144 (2003).","journal-title":"Methods Mol. Med."},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-61779-415-5_13"}],"container-title":["Science Translational Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/scitranslmed.aac5380","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,16]],"date-time":"2024-01-16T18:08:57Z","timestamp":1705428537000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/scitranslmed.aac5380"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,9,30]]},"references-count":41,"journal-issue":{"issue":"307","published-print":{"date-parts":[[2015,9,30]]}},"alternative-id":["10.1126\/scitranslmed.aac5380"],"URL":"https:\/\/doi.org\/10.1126\/scitranslmed.aac5380","relation":{},"ISSN":["1946-6234","1946-6242"],"issn-type":[{"value":"1946-6234","type":"print"},{"value":"1946-6242","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,9,30]]}}}