{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T14:01:34Z","timestamp":1793109694146,"version":"4.5.0"},"reference-count":64,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"431","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sci. Transl. Med."],"published-print":{"date-parts":[[2018,3,7]]},"abstract":"<jats:p>T follicular helper\u2013like cells and IL-21 are drivers of skin fibrosis in systemic sclerosis.<\/jats:p>","DOI":"10.1126\/scitranslmed.aaf5307","type":"journal-article","created":{"date-parts":[[2018,3,7]],"date-time":"2018-03-07T14:11:47Z","timestamp":1520431907000},"source":"Crossref","is-referenced-by-count":110,"title":["T follicular helper\u2013like cells contribute to skin fibrosis"],"prefix":"10.1126","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8605-9550","authenticated-orcid":false,"given":"Devon K.","family":"Taylor","sequence":"first","affiliation":[{"name":"Department of Respiratory, Inflammation and Autoimmunity, MedImmune LLC, Gaithersburg, MD 20878, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nanette","family":"Mittereder","sequence":"additional","affiliation":[{"name":"Department of Respiratory, Inflammation and Autoimmunity, MedImmune LLC, Gaithersburg, MD 20878, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ellen","family":"Kuta","sequence":"additional","affiliation":[{"name":"Department of Respiratory, Inflammation and Autoimmunity, MedImmune LLC, Gaithersburg, MD 20878, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tracy","family":"Delaney","sequence":"additional","affiliation":[{"name":"Department of Respiratory, Inflammation and Autoimmunity, MedImmune LLC, Gaithersburg, MD 20878, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy","family":"Burwell","sequence":"additional","affiliation":[{"name":"Department of Respiratory, Inflammation and Autoimmunity, MedImmune LLC, Gaithersburg, MD 20878, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9600-1889","authenticated-orcid":false,"given":"Karma","family":"Dacosta","sequence":"additional","affiliation":[{"name":"Department of Pathology, MedImmune LLC, Gaithersburg, MD 20878, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiguang","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Pathology, MedImmune LLC, Gaithersburg, MD 20878, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3056-1891","authenticated-orcid":false,"given":"Lily I.","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Pathology, MedImmune LLC, Gaithersburg, MD 20878, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles","family":"Brown","sequence":"additional","affiliation":[{"name":"Department of Pathology, MedImmune LLC, Gaithersburg, MD 20878, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2425-5847","authenticated-orcid":false,"given":"Anmarie","family":"Boutrin","sequence":"additional","affiliation":[{"name":"Department of Pathology, MedImmune LLC, Gaithersburg, MD 20878, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3307-2388","authenticated-orcid":false,"given":"Xiang","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Clinical Biomarkers and Computational Biology, MedImmune LLC, Gaithersburg, MD 20878, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wendy I.","family":"White","sequence":"additional","affiliation":[{"name":"Department of Clinical Biomarkers and Computational Biology, MedImmune LLC, Gaithersburg, MD 20878, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Antibody Discovery and Protein Engineering, MedImmune LLC, Gaithersburg, MD 20878, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7534-9974","authenticated-orcid":false,"given":"Huifang","family":"Dong","sequence":"additional","affiliation":[{"name":"Department of Antibody Discovery and Protein Engineering, MedImmune LLC, Gaithersburg, MD 20878, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael A.","family":"Bowen","sequence":"additional","affiliation":[{"name":"Department of Antibody Discovery and Protein Engineering, MedImmune LLC, Gaithersburg, MD 20878, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Antibody Discovery and Protein Engineering, MedImmune LLC, Gaithersburg, MD 20878, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5781-6559","authenticated-orcid":false,"given":"Changshou","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Antibody Discovery and Protein Engineering, MedImmune LLC, Gaithersburg, MD 20878, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0115-6747","authenticated-orcid":false,"given":"Li","family":"Yu","sequence":"additional","affiliation":[{"name":"Clinical Pharmacology, Pharmacometrics, and DMPK (CPD), MedImmune LLC, Gaithersburg, MD 20878, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8870-5328","authenticated-orcid":false,"given":"Madhu","family":"Ramaswamy","sequence":"additional","affiliation":[{"name":"Department of Respiratory, Inflammation and Autoimmunity, MedImmune LLC, Gaithersburg, MD 20878, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2833-7951","authenticated-orcid":false,"given":"Marie-Claude","family":"Gaudreau","sequence":"additional","affiliation":[{"name":"Department of Respiratory, Inflammation and Autoimmunity, MedImmune LLC, Gaithersburg, MD 20878, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rob","family":"Woods","sequence":"additional","affiliation":[{"name":"Department of Antibody Discovery and Protein Engineering, MedImmune LLC, Gaithersburg, MD 20878, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald","family":"Herbst","sequence":"additional","affiliation":[{"name":"Department of Respiratory, Inflammation and Autoimmunity, MedImmune LLC, Gaithersburg, MD 20878, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9592-3267","authenticated-orcid":false,"given":"Gianluca","family":"Carlesso","sequence":"additional","affiliation":[{"name":"Department of Respiratory, Inflammation and Autoimmunity, MedImmune LLC, Gaithersburg, MD 20878, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra0806188"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00414.2010"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri1412"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780270607"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2004.027094"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kes090"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncprheum0346"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2010.09.016"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.20562"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1186\/ar1454"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2011-200837"},{"key":"e_1_3_2_13_2","first-page":"68","article-title":"Correlation of serum collagen I carboxyterminal telopeptide concentrations with cutaneous and pulmonary involvement in systemic sclerosis","volume":"30","author":"Allanore Y.","year":"2003","unstructured":"Y. Allanore, D. Borderie, H. Lemar\u00e9chal, B. Cherruau, O. G. Ekindjian, A. Kahan, Correlation of serum collagen I carboxyterminal telopeptide concentrations with cutaneous and pulmonary involvement in systemic sclerosis. J. Rheumatol. 30, 68\u201373 (2003).","journal-title":"J. Rheumatol."},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2015.188"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1093\/clinchem\/44.11.2290"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.194.6.809"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1996.03890310088013"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.20883"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI27727"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1038\/16717"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.180.2.774"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.166.1.1"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.192.1.53"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni.1690"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2011.03.023"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1038\/35051113"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2008.06.001"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.39020"},{"key":"e_1_3_2_29_2","first-page":"1157","article-title":"Expression and function of the co-stimulator H4\/ICOS on activated T cells of patients with rheumatoid arthritis","volume":"30","author":"Okamoto T.","year":"2003","unstructured":"T. Okamoto, S. Saito, H. Yamanaka, T. Tomatsu, N. Kamatani, H. Ogiuchi, T. Uchiyama, J. Yagi, Expression and function of the co-stimulator H4\/ICOS on activated T cells of patients with rheumatoid arthritis. J. Rheumatol. 30, 1157\u20131163 (2003).","journal-title":"J. Rheumatol."},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keh724"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kes258"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00403-012-1292-7"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.27428"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni.2947"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.20160"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1002\/path.2277"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1097\/00002281-200011000-00009"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)63776-5"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3008146"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2011.11.012"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0144654"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/34.11.1048"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2004.03.001"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2010.07.015"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1175870"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1521-4141(199905)29:05<1610::AID-IMMU1610>3.0.CO;2-8"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20021750"},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2011-200955"},{"key":"e_1_3_2_49_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.185.3.461"},{"key":"e_1_3_2_50_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0923-1811(01)00128-1"},{"key":"e_1_3_2_51_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2012.10.010"},{"key":"e_1_3_2_52_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm.1995"},{"key":"e_1_3_2_53_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1500777"},{"key":"e_1_3_2_54_2","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.5A0516-217RR"},{"key":"e_1_3_2_55_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-6143.2003.00114.x"},{"key":"e_1_3_2_56_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.24432"},{"key":"e_1_3_2_57_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2011.11.024"},{"key":"e_1_3_2_58_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.173.6.4020"},{"key":"e_1_3_2_59_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.20519"},{"key":"e_1_3_2_60_2","doi-asserted-by":"publisher","DOI":"10.1002\/cyto.a.20383"},{"key":"e_1_3_2_61_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awh148"},{"key":"e_1_3_2_62_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.25032"},{"key":"e_1_3_2_63_2","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.110.168062"},{"key":"e_1_3_2_64_2","doi-asserted-by":"publisher","DOI":"10.1107\/S0907444908007877"},{"key":"e_1_3_2_65_2","doi-asserted-by":"publisher","DOI":"10.1089\/15368590152740699"}],"container-title":["Science Translational Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/scitranslmed.aaf5307","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,16]],"date-time":"2024-01-16T12:54:52Z","timestamp":1705409692000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/scitranslmed.aaf5307"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,3,7]]},"references-count":64,"journal-issue":{"issue":"431","published-print":{"date-parts":[[2018,3,7]]}},"alternative-id":["10.1126\/scitranslmed.aaf5307"],"URL":"https:\/\/doi.org\/10.1126\/scitranslmed.aaf5307","relation":{},"ISSN":["1946-6234","1946-6242"],"issn-type":[{"value":"1946-6234","type":"print"},{"value":"1946-6242","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,3,7]]},"article-number":"eaaf5307"}}