{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T09:55:54Z","timestamp":1793354154295,"version":"4.5.0"},"reference-count":50,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"370","license":[{"start":{"date-parts":[[2017,12,21]],"date-time":"2017-12-21T00:00:00Z","timestamp":1513814400000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/www.sciencemag.org\/about\/science-licenses-journal-article-reuse"}],"funder":[{"name":"Alliance Biosecure Foundation"},{"DOI":"10.13039\/501100001677","name":"INSERM","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001677","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009571","name":"Institut de Veille Sanitaire","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100009571","id-type":"DOI","asserted-by":"crossref"}]},{"name":"U.K. Department of Health Policy Research Programme","award":["PRST061400008"],"award-info":[{"award-number":["PRST061400008"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sci. Transl. Med."],"published-print":{"date-parts":[[2016,12,21]]},"abstract":"<jats:p>A sensitive blood diagnostic assay can identify patients with variant Creutzfeldt-Jakob disease before symptoms appear and during the clinical phase.<\/jats:p>","DOI":"10.1126\/scitranslmed.aag1257","type":"journal-article","created":{"date-parts":[[2016,12,21]],"date-time":"2016-12-21T14:15:43Z","timestamp":1482329743000},"source":"Crossref","is-referenced-by-count":139,"title":["Detection of prions in the plasma of presymptomatic and symptomatic patients with variant Creutzfeldt-Jakob disease"],"prefix":"10.1126","volume":"8","author":[{"given":"Daisy","family":"Bougard","sequence":"first","affiliation":[{"name":"Etablissement Fran\u00e7ais du Sang, INSERM, Universit\u00e9 de Montpellier, UMR 1058, TransDiag, F-34184 Montpellier, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Philippe","family":"Brandel","sequence":"additional","affiliation":[{"name":"Sorbonne Universit\u00e9s, UPMC Univ Paris 06, INSERM, CNRS, Institut du Cerveau et de la Moelle \u00e9pini\u00e8re (ICM)\u2013H\u00f4pital Piti\u00e9-Salp\u00eatri\u00e8re, F-75013 Paris, France."},{"name":"Assistance publique\u2013H\u00f4pitaux de Paris, Cellule Nationale de R\u00e9f\u00e9rence des Maladies de Creutzfeldt-Jakob, Groupe Hospitalier Piti\u00e9-Salp\u00eatri\u00e8re, F-75013 Paris, France."},{"name":"Centre National de R\u00e9f\u00e9rence des Agents Transmissibles Non Conventionnels, F-75013 Paris, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maxime","family":"B\u00e9londrade","sequence":"additional","affiliation":[{"name":"Etablissement Fran\u00e7ais du Sang, INSERM, Universit\u00e9 de Montpellier, UMR 1058, TransDiag, F-34184 Montpellier, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent","family":"B\u00e9ringue","sequence":"additional","affiliation":[{"name":"Institut National de la Recherche Agronomique, Universit\u00e9 Paris-Saclay, Virologie Immunologie Mol\u00e9culaire, F-78350 Jouy-en-Josas, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christiane","family":"Segarra","sequence":"additional","affiliation":[{"name":"Etablissement Fran\u00e7ais du Sang, INSERM, Universit\u00e9 de Montpellier, UMR 1058, TransDiag, F-34184 Montpellier, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Herv\u00e9","family":"Fleury","sequence":"additional","affiliation":[{"name":"Laboratoire de Virologie, H\u00f4pital Pellegrin, F-33076 Bordeaux, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Louis","family":"Laplanche","sequence":"additional","affiliation":[{"name":"Centre National de R\u00e9f\u00e9rence des Agents Transmissibles Non Conventionnels, F-75013 Paris, France."},{"name":"Service de Biochimie et Biologie Mol\u00e9culaire, H\u00f4pital Lariboisi\u00e8re, F-75010 Paris, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charly","family":"Mayran","sequence":"additional","affiliation":[{"name":"Etablissement Fran\u00e7ais du Sang, INSERM, Universit\u00e9 de Montpellier, UMR 1058, TransDiag, F-34184 Montpellier, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Nicot","sequence":"additional","affiliation":[{"name":"Etablissement Fran\u00e7ais du Sang, INSERM, Universit\u00e9 de Montpellier, UMR 1058, TransDiag, F-34184 Montpellier, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alison","family":"Green","sequence":"additional","affiliation":[{"name":"National Creutzfeldt-Jakob Disease Research and Surveillance Unit, Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh EH4 2XU, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arlette","family":"Welaratne","sequence":"additional","affiliation":[{"name":"Assistance publique\u2013H\u00f4pitaux de Paris, Cellule Nationale de R\u00e9f\u00e9rence des Maladies de Creutzfeldt-Jakob, Groupe Hospitalier Piti\u00e9-Salp\u00eatri\u00e8re, F-75013 Paris, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Narbey","sequence":"additional","affiliation":[{"name":"Etablissement Fran\u00e7ais du Sang, F-93218 La Plaine Saint Denis, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chantal","family":"Fournier-Wirth","sequence":"additional","affiliation":[{"name":"Etablissement Fran\u00e7ais du Sang, INSERM, Universit\u00e9 de Montpellier, UMR 1058, TransDiag, F-34184 Montpellier, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Knight","sequence":"additional","affiliation":[{"name":"National Creutzfeldt-Jakob Disease Research and Surveillance Unit, Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh EH4 2XU, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Will","sequence":"additional","affiliation":[{"name":"National Creutzfeldt-Jakob Disease Research and Surveillance Unit, Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh EH4 2XU, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Tiberghien","sequence":"additional","affiliation":[{"name":"Etablissement Fran\u00e7ais du Sang, F-93218 La Plaine Saint Denis, France."},{"name":"INSERM, Etablissement Fran\u00e7ais du Sang, Universit\u00e9 de Franche-Comt\u00e9, UMR 1098, F-25020 Besan\u00e7on, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"St\u00e9phane","family":"Ha\u00efk","sequence":"additional","affiliation":[{"name":"Sorbonne Universit\u00e9s, UPMC Univ Paris 06, INSERM, CNRS, Institut du Cerveau et de la Moelle \u00e9pini\u00e8re (ICM)\u2013H\u00f4pital Piti\u00e9-Salp\u00eatri\u00e8re, F-75013 Paris, France."},{"name":"Assistance publique\u2013H\u00f4pitaux de Paris, Cellule Nationale de R\u00e9f\u00e9rence des Maladies de Creutzfeldt-Jakob, Groupe Hospitalier Piti\u00e9-Salp\u00eatri\u00e8re, F-75013 Paris, France."},{"name":"Centre National de R\u00e9f\u00e9rence des Agents Transmissibles Non Conventionnels, F-75013 Paris, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joliette","family":"Coste","sequence":"additional","affiliation":[{"name":"Etablissement Fran\u00e7ais du Sang, INSERM, Universit\u00e9 de Montpellier, UMR 1058, TransDiag, F-34184 Montpellier, France."},{"name":"Etablissement Fran\u00e7ais du Sang, F-93218 La Plaine Saint Denis, France."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/39057"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(96)91412-9"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.21583"},{"key":"e_1_3_2_5_2","unstructured":"National Creutzfeldt-Jakob Disease Research and Surveillance Unit Variant Creutzfeldt-Jakob Disease Cases Worldwide (2016); www.cjd.ed.ac.uk\/documents\/worldfigs.pdf."},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(98)12075-5"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(01)05403-4"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1002782"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.2002.00098.x"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)02719-7"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0042019"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(04)15486-X"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(04)16811-6"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(06)69835-8"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2009.02181.x"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.76.9.4649-4650.2002"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.f5675"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/path.1580"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)62308-2"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2013-11-539239"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2013.6001"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1004202"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.00078-11"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1129051"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1404401"},{"key":"e_1_3_2_26_2","unstructured":"European Commission Technical specifications for in vitro diagnostic medical devices (Official Journal of the European Union 2011)."},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1038\/35081095"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1038\/35044100"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)05110-2"},{"key":"e_1_3_2_30_2","first-page":"5102","article-title":"Plasminogen stimulates propagation of protease-resistant prion protein in vitro","volume":"24","author":"Mays C. E.","year":"2010","unstructured":"C. E. Mays, C. Ryou, Plasminogen stimulates propagation of protease-resistant prion protein in vitro. FASEB J. 24, 5102\u20135112 (2010).","journal-title":"FASEB J."},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0069632"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aaf6188"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.3201\/eid2001.130353"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth0308-211"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1001217"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2294"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.23589"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1315200"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1099\/vir.0.033365-0"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1423-0410.2009.01222.x"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2013.5378"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.1465"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2014-309397"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1159\/000332764"},{"key":"e_1_3_2_45_2","unstructured":"M. Zeildler C. Gibbs F. Meslin WHO manual for strenthening diagnosis and surveillance of Creutzfeldt-Jakob disease. (1998)."},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awp191"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0001419"},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0005796"},{"key":"e_1_3_2_49_2","doi-asserted-by":"publisher","DOI":"10.1093\/biomet\/26.4.404"},{"key":"e_1_3_2_50_2","unstructured":"R. C. Team R: A language and environment for statistical computing. (2014)."},{"key":"e_1_3_2_51_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-1004(200005)15:5<482::AID-HUMU16>3.0.CO;2-1"}],"container-title":["Science Translational Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/scitranslmed.aag1257","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,16]],"date-time":"2024-01-16T12:25:31Z","timestamp":1705407931000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/scitranslmed.aag1257"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,12,21]]},"references-count":50,"journal-issue":{"issue":"370","published-print":{"date-parts":[[2016,12,21]]}},"alternative-id":["10.1126\/scitranslmed.aag1257"],"URL":"https:\/\/doi.org\/10.1126\/scitranslmed.aag1257","relation":{},"ISSN":["1946-6234","1946-6242"],"issn-type":[{"value":"1946-6234","type":"print"},{"value":"1946-6242","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,12,21]]}}}