{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T19:25:12Z","timestamp":1792178712384,"version":"4.4.0"},"reference-count":48,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"365","license":[{"start":{"date-parts":[[2017,11,16]],"date-time":"2017-11-16T00:00:00Z","timestamp":1510790400000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/www.sciencemag.org\/about\/science-licenses-journal-article-reuse"}],"funder":[{"DOI":"10.13039\/100005156","name":"Alexander von Humboldt-Stiftung Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100005156","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["EB-000244"],"award-info":[{"award-number":["EB-000244"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["T32 5T32HL007604-29"],"award-info":[{"award-number":["T32 5T32HL007604-29"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000038","name":"National Sciences and Engineering Research Council of Canada","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000865","name":"Bill and Melinda Gates Foundation","doi-asserted-by":"publisher","award":["OPP1096734"],"award-info":[{"award-number":["OPP1096734"]}],"id":[{"id":"10.13039\/100000865","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000865","name":"Bill and Melinda Gates Foundation","doi-asserted-by":"publisher","award":["OPP1139921"],"award-info":[{"award-number":["OPP1139921"]}],"id":[{"id":"10.13039\/100000865","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000865","name":"Bill and Melinda Gates Foundation","doi-asserted-by":"publisher","award":["OPP1068440"],"award-info":[{"award-number":["OPP1068440"]}],"id":[{"id":"10.13039\/100000865","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sci. Transl. Med."],"published-print":{"date-parts":[[2016,11,16]]},"abstract":"<jats:p>A newly developed platform capable of oral, ultra\u2013long-acting drug delivery could be applied against the malaria vector in elimination programs.<\/jats:p>","DOI":"10.1126\/scitranslmed.aag2374","type":"journal-article","created":{"date-parts":[[2016,11,17]],"date-time":"2016-11-17T05:45:23Z","timestamp":1479361523000},"source":"Crossref","is-referenced-by-count":243,"title":["Oral, ultra\u2013long-lasting drug delivery: Application toward malaria elimination goals"],"prefix":"10.1126","volume":"8","author":[{"given":"Andrew M.","family":"Bellinger","sequence":"first","affiliation":[{"name":"Department of Chemical Engineering and Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA."},{"name":"Cardiovascular Division, Department of Medicine, Brigham and Women\u2019s Hospital, Harvard Medical School, Boston, MA 02115, USA."},{"name":"Lyndra Inc., Watertown, MA 02472, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mousa","family":"Jafari","sequence":"additional","affiliation":[{"name":"Department of Chemical Engineering and Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tyler M.","family":"Grant","sequence":"additional","affiliation":[{"name":"Department of Chemical Engineering and Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA."},{"name":"Lyndra Inc., Watertown, MA 02472, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiyi","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Chemical Engineering and Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannah C.","family":"Slater","sequence":"additional","affiliation":[{"name":"Department of Infectious Disease Epidemiology, MRC (Medical Research Council) Centre for Outbreak Analysis and Modelling, Imperial College London, London, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward A.","family":"Wenger","sequence":"additional","affiliation":[{"name":"Institute for Disease Modeling, Bellevue, WA 98005, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stacy","family":"Mo","sequence":"additional","affiliation":[{"name":"Department of Chemical Engineering and Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young-Ah Lucy","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Chemical Engineering and Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hormoz","family":"Mazdiyasni","sequence":"additional","affiliation":[{"name":"Department of Chemical Engineering and Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lawrence","family":"Kogan","sequence":"additional","affiliation":[{"name":"Department of Chemical Engineering and Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ross","family":"Barman","sequence":"additional","affiliation":[{"name":"Department of Chemical Engineering and Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cody","family":"Cleveland","sequence":"additional","affiliation":[{"name":"Department of Chemical Engineering and Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA."},{"name":"Division of Gastroenterology, Brigham and Women\u2019s Hospital, Harvard Medical School, Boston, MA 02115, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucas","family":"Booth","sequence":"additional","affiliation":[{"name":"Department of Chemical Engineering and Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taylor","family":"Bensel","sequence":"additional","affiliation":[{"name":"Department of Chemical Engineering and Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Minahan","sequence":"additional","affiliation":[{"name":"Department of Chemical Engineering and Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haley M.","family":"Hurowitz","sequence":"additional","affiliation":[{"name":"Department of Chemical Engineering and Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tammy","family":"Tai","sequence":"additional","affiliation":[{"name":"Department of Chemical Engineering and Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johanna","family":"Daily","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Albert Einstein College of Medicine, Bronx, NY 10461, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boris","family":"Nikolic","sequence":"additional","affiliation":[{"name":"Biomatics Capital, 1107 1st Avenue, Apartment 1305, Seattle, WA 98101, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lowell","family":"Wood","sequence":"additional","affiliation":[{"name":"Institute for Disease Modeling, Bellevue, WA 98005, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip A.","family":"Eckhoff","sequence":"additional","affiliation":[{"name":"Institute for Disease Modeling, Bellevue, WA 98005, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Langer","sequence":"additional","affiliation":[{"name":"Department of Chemical Engineering and Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA."},{"name":"Media Lab, Massachusetts Institute of Technology, Cambridge, MA 02139, USA."},{"name":"Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA 02139, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Traverso","sequence":"additional","affiliation":[{"name":"Department of Chemical Engineering and Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA."},{"name":"Division of Gastroenterology, Brigham and Women\u2019s Hospital, Harvard Medical School, Boston, MA 02115, USA."},{"name":"Division of Gastroenterology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-3659(99)00204-7"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1517\/17425247.3.4.541"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.3109\/10717544.2014.905654"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1517\/17425247.2011.586334"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1015981627525"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1015976709043"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1018939512213"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/AJP.0b013e31827b32ab"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/nmat4355"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)62566-0"},{"key":"e_1_3_2_12_2","unstructured":"World Health Organization (WHO) World Malaria Report 2015 (WHO\/HTM\/GMP\/2016.2 WHO 2015); www.who.int\/malaria\/publications\/world-malaria-report-2015\/report\/en\/."},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature15535"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.14-0254"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1000402"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1093\/trstmh\/tru204"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.2010.09-0774"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.13-0646"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1179\/2047773211Y.0000000015"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1038\/329752a0"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0003319"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1500987"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciu797"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1186\/1475-2875-9-365"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.actatropica.2011.10.007"},{"key":"e_1_3_2_26_2","unstructured":"Center for Drug Evaluation and Research (CDER) Stromectol FDA label (CDER 2007) pp. 1\u20136; www.accessdata.fda.gov\/drugsatfda_docs\/label\/2009\/050742s024s025lbl.pdf. Accessed on November 6 2016 previously accessed on July 14 2016."},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1186\/1475-2875-12-153"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12864-015-2029-8"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiu351"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12936-015-0691-6"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1086\/653208"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciu802"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1186\/1475-2875-11-381"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9610(72)90036-0"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1038\/519S19a"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00464-008-9756-8"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1002292107"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1002\/jps.2600811208"},{"key":"e_1_3_2_39_2","unstructured":"D. C. Plumb Plumb\u2019s Veterinary Drug Handbook (Blackwell Publishing ed. 6 2008)."},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.12-0007"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-015-0887-y"},{"key":"e_1_3_2_42_2","unstructured":"WHO Consensus modelling evidence to support the design of mass drug administration programmes (WHO 2015); www.who.int\/malaria\/mpac\/mpac-sept2015-consensus-modelling-mda.pdf"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12936-015-0618-2"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2003.09.015"},{"key":"e_1_3_2_45_2","unstructured":"Merial Ivermectin (IVOMEC) Material Safety Data Sheet (ISO\/DIS 11014\/29 CFR 1910.1200\/ANSI Z400.1 Merial 2010)."},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00464-008-9915-y"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.1002\/app.1980.070250203"},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0928-0987(00)00181-0"},{"key":"e_1_3_2_49_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms4136"}],"container-title":["Science Translational Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/scitranslmed.aag2374","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,16]],"date-time":"2024-01-16T12:28:57Z","timestamp":1705408137000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/scitranslmed.aag2374"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,11,16]]},"references-count":48,"journal-issue":{"issue":"365","published-print":{"date-parts":[[2016,11,16]]}},"alternative-id":["10.1126\/scitranslmed.aag2374"],"URL":"https:\/\/doi.org\/10.1126\/scitranslmed.aag2374","relation":{},"ISSN":["1946-6234","1946-6242"],"issn-type":[{"value":"1946-6234","type":"print"},{"value":"1946-6242","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,11,16]]}}}