{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T04:08:29Z","timestamp":1792642109057,"version":"4.5.0"},"reference-count":39,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"375","license":[{"start":{"date-parts":[[2018,2,1]],"date-time":"2018-02-01T00:00:00Z","timestamp":1517443200000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/www.sciencemag.org\/about\/science-licenses-journal-article-reuse"}],"funder":[{"DOI":"10.13039\/100006260","name":"Rheumatology Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006260","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["R01 AI073755"],"award-info":[{"award-number":["R01 AI073755"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["R01 AI104972"],"award-info":[{"award-number":["R01 AI104972"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["R01 AI114816"],"award-info":[{"award-number":["R01 AI114816"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["P30 AR057235"],"award-info":[{"award-number":["P30 AR057235"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sci. Transl. Med."],"published-print":{"date-parts":[[2017,2]]},"abstract":"<jats:p>Combination therapy with CTLA4-Ig and an antiviral human monoclonal antibody controls chikungunya virus arthritis in mice.<\/jats:p>","DOI":"10.1126\/scitranslmed.aah3438","type":"journal-article","created":{"date-parts":[[2017,2,1]],"date-time":"2017-02-01T14:40:09Z","timestamp":1485960009000},"source":"Crossref","is-referenced-by-count":77,"title":["Therapy with CTLA4-Ig and an antiviral monoclonal antibody controls chikungunya virus arthritis"],"prefix":"10.1126","volume":"9","author":[{"given":"Jonathan J.","family":"Miner","sequence":"first","affiliation":[{"name":"Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA."},{"name":"Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA."},{"name":"Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lindsey E.","family":"Cook","sequence":"additional","affiliation":[{"name":"Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun P.","family":"Hong","sequence":"additional","affiliation":[{"name":"Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amber M.","family":"Smith","sequence":"additional","affiliation":[{"name":"Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justin M.","family":"Richner","sequence":"additional","affiliation":[{"name":"Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raeann M.","family":"Shimak","sequence":"additional","affiliation":[{"name":"Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alissa R.","family":"Young","sequence":"additional","affiliation":[{"name":"Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristen","family":"Monte","sequence":"additional","affiliation":[{"name":"Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Subhajit","family":"Poddar","sequence":"additional","affiliation":[{"name":"Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr","given":"James E.","family":"Crowe","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN 37232, USA."},{"name":"Vanderbilt Vaccine Center, Vanderbilt University Medical Center, Nashville, TN 37232, USA."},{"name":"Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN 37232, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deborah J.","family":"Lenschow","sequence":"additional","affiliation":[{"name":"Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA."},{"name":"Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA."},{"name":"Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael S.","family":"Diamond","sequence":"additional","affiliation":[{"name":"Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA."},{"name":"Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA."},{"name":"Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110, USA."},{"name":"Center for Human Immunology and Immunotherapy Programs, Washington University School of Medicine, St. Louis, MO 63110, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0022172400044442"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.12688\/f1000research.7171.1"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.39027"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2010.11.018"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.12688\/f1000research.8235.1"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1086\/590003"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0000389"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-015-3302-5"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.trstmh.2010.01.011"},{"key":"e_1_3_2_11_2","first-page":"130","article-title":"Rheumatoid arthritic syndrome after chikungunya fever","volume":"56","author":"Fourie E. D.","year":"1979","unstructured":"E. D. Fourie, J. G. Morrison, Rheumatoid arthritic syndrome after chikungunya fever. S. Afr. Med. J. 56, 130\u2013132 (1979).","journal-title":"S. Afr. Med. J."},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2008.097626"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.3109\/03009748709165409"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.113.209304"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1109071"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.38221"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0973-3698(10)60125-2"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02603-09"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0155243"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.34631"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1202177"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jir470"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1003312"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2013.10.004"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0002423"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1323143"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2006.050907"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2015.06.009"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02666-13"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1186\/ar2865"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830221115"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.178.5.1789"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aal1333"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.0040029"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1310476"},{"key":"e_1_3_2_36_2","first-page":"2817","article-title":"Management of chronic post-Chikungunya rheumatic disease: The martinican experience","volume":"68","author":"Brunier L.","year":"2016","unstructured":"M. Blettery, L. Brunier, K. Polomat, F. Moinet, C. Deligny, S. Arfi, G. Jean-Baptiste, M. De Bandt, Management of chronic post-Chikungunya rheumatic disease: The martinican experience. Arthritis Rheumatol. 68, 2817\u20132824 (2016).","journal-title":"M."},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.30112"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ibmb.2005.05.008"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0028360"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm1240"}],"container-title":["Science Translational Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/scitranslmed.aah3438","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,16]],"date-time":"2024-01-16T13:24:23Z","timestamp":1705411463000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/scitranslmed.aah3438"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,2]]},"references-count":39,"journal-issue":{"issue":"375","published-print":{"date-parts":[[2017,2]]}},"alternative-id":["10.1126\/scitranslmed.aah3438"],"URL":"https:\/\/doi.org\/10.1126\/scitranslmed.aah3438","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.727261695.793539888","asserted-by":"object"}]},"ISSN":["1946-6234","1946-6242"],"issn-type":[{"value":"1946-6234","type":"print"},{"value":"1946-6242","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,2]]},"article-number":"eaah3438"}}