{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T13:14:04Z","timestamp":1793366044176,"version":"4.5.0"},"reference-count":36,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"384","license":[{"start":{"date-parts":[[2018,4,5]],"date-time":"2018-04-05T00:00:00Z","timestamp":1522886400000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/www.sciencemag.org\/about\/science-licenses-journal-article-reuse"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["award280341"],"award-info":[{"award-number":["award280341"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AI109762,AI082744,U19AI109711,UC7AI094660"],"award-info":[{"award-number":["AI109762,AI082744,U19AI109711,UC7AI094660"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sci. Transl. Med."],"published-print":{"date-parts":[[2017,4,5]]},"abstract":"<jats:p>A single mAb is an effective therapy in nonhuman primates infected with Marburg or Ravn virus.<\/jats:p>","DOI":"10.1126\/scitranslmed.aai8711","type":"journal-article","created":{"date-parts":[[2017,4,5]],"date-time":"2017-04-05T14:15:34Z","timestamp":1491401734000},"source":"Crossref","is-referenced-by-count":95,"title":["Therapeutic treatment of Marburg and Ravn virus infection in nonhuman primates with a human monoclonal antibody"],"prefix":"10.1126","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7596-1808","authenticated-orcid":false,"given":"Chad E.","family":"Mire","sequence":"first","affiliation":[{"name":"Galveston National Laboratory, University of Texas Medical Branch, Galveston, TX 77555, USA."},{"name":"Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX 77555, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0858-1877","authenticated-orcid":false,"given":"Joan B.","family":"Geisbert","sequence":"additional","affiliation":[{"name":"Galveston National Laboratory, University of Texas Medical Branch, Galveston, TX 77555, USA."},{"name":"Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX 77555, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viktoriya","family":"Borisevich","sequence":"additional","affiliation":[{"name":"Galveston National Laboratory, University of Texas Medical Branch, Galveston, TX 77555, USA."},{"name":"Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX 77555, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karla A.","family":"Fenton","sequence":"additional","affiliation":[{"name":"Galveston National Laboratory, University of Texas Medical Branch, Galveston, TX 77555, USA."},{"name":"Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX 77555, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krystle N.","family":"Agans","sequence":"additional","affiliation":[{"name":"Galveston National Laboratory, University of Texas Medical Branch, Galveston, TX 77555, USA."},{"name":"Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX 77555, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8722-479X","authenticated-orcid":false,"given":"Andrew I.","family":"Flyak","sequence":"additional","affiliation":[{"name":"Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN 37232, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel J.","family":"Deer","sequence":"additional","affiliation":[{"name":"Galveston National Laboratory, University of Texas Medical Branch, Galveston, TX 77555, USA."},{"name":"Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX 77555, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4823-1505","authenticated-orcid":false,"given":"Herta","family":"Steinkellner","sequence":"additional","affiliation":[{"name":"Department of Applied Genetics and Cell Biology, University of Natural Resources and Life Sciences, 1190 Vienna, Austria."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ognian","family":"Bohorov","sequence":"additional","affiliation":[{"name":"Mapp Biopharmaceutical Inc., San Diego, CA 92121, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natasha","family":"Bohorova","sequence":"additional","affiliation":[{"name":"Mapp Biopharmaceutical Inc., San Diego, CA 92121, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles","family":"Goodman","sequence":"additional","affiliation":[{"name":"Mapp Biopharmaceutical Inc., San Diego, CA 92121, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Hiatt","sequence":"additional","affiliation":[{"name":"Mapp Biopharmaceutical Inc., San Diego, CA 92121, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2725-4153","authenticated-orcid":false,"given":"Do H.","family":"Kim","sequence":"additional","affiliation":[{"name":"Mapp Biopharmaceutical Inc., San Diego, CA 92121, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael H.","family":"Pauly","sequence":"additional","affiliation":[{"name":"Mapp Biopharmaceutical Inc., San Diego, CA 92121, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jesus","family":"Velasco","sequence":"additional","affiliation":[{"name":"Mapp Biopharmaceutical Inc., San Diego, CA 92121, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin J.","family":"Whaley","sequence":"additional","affiliation":[{"name":"Department of Applied Genetics and Cell Biology, University of Natural Resources and Life Sciences, 1190 Vienna, Austria."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0049-1079","authenticated-orcid":false,"suffix":"Jr..","given":"James E.","family":"Crowe","sequence":"additional","affiliation":[{"name":"Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN 37232, USA."},{"name":"Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN 37232, USA."},{"name":"Vanderbilt Vaccine Center, Vanderbilt University Medical Center, Nashville, TN 37232, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6857-1024","authenticated-orcid":false,"given":"Larry","family":"Zeitlin","sequence":"additional","affiliation":[{"name":"Mapp Biopharmaceutical Inc., San Diego, CA 92121, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0858-1877","authenticated-orcid":false,"given":"Thomas W.","family":"Geisbert","sequence":"additional","affiliation":[{"name":"Galveston National Laboratory, University of Texas Medical Branch, Galveston, TX 77555, USA."},{"name":"Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX 77555, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","unstructured":"A. Sanchez H. Feldmann T. W. Geisbert Filoviridae: Marburg and Ebola viruses in Fields Virology D. M. Knipe P. M. Howley Eds. (Lippincott Williams & Wilkins 2013) pp. 923\u2013956."},{"key":"e_1_3_2_3_2","doi-asserted-by":"crossref","unstructured":"M. Leitenberg R. A. Zilinskas The Soviet Biological Weapons Program: A History (Harvard Univ. Press 2012).","DOI":"10.4159\/harvard.9780674065260"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.4161\/19420862.2015.989042"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/21.1.150"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1286-4579(00)00355-5"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3008929"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3002901"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3006608"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature13777"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.2174\/1570163810666131120150043"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2009.10.124"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jit119"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2015.06.009"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.aad5788"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2015.01.031"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0606631103"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiv182"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jit465"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiv126"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3009706"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1086\/520608"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1213709109"},{"key":"e_1_3_2_24_2","first-page":"101","article-title":"Characterization of a new Marburg virus isolated from a 1987 fatal case in Kenya","volume":"11","author":"Johnson E. D.","year":"1996","unstructured":"E. D. Johnson, B. K. Johnson, D. Silverstein, P. Tukei, T. W. Geisbert, A. N. Sanchez, P. B. Jahrling, Characterization of a new Marburg virus isolated from a 1987 fatal case in Kenya. Arch. Virol. Suppl. 11, 101\u2013114 (1996).","journal-title":"Arch. Virol. Suppl."},{"key":"e_1_3_2_25_2","first-page":"135","article-title":"Passive immunization of Ebola virus-infected cynomolgus monkeys with immunoglobulin from hyperimmune horses","volume":"11","author":"Jahrling P. B.","year":"1996","unstructured":"P. B. Jahrling, J. Geisbert, J. R. Swearengen, G. P. Jaax, T. Lewis, J. W. Huggins, J. J. Schmidt, J. W. LeDuc, C. J. Peters, Passive immunization of Ebola virus-infected cynomolgus monkeys with immunoglobulin from hyperimmune horses. Arch. Virol. Suppl. 11, 135\u2013140 (1996).","journal-title":"Arch. Virol. Suppl."},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1086\/520587"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.0030009"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1200409109"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.2174\/1570162X113116660057"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.aad5224"},{"key":"e_1_3_2_31_2","first-page":"e820","article-title":"Updated guidance for palivizumab prophylaxis among infants and young children at increased risk of hospitalization for respiratory syncytial virus infection","volume":"134","author":"American Academy of Pediatrics Committee on Infectious Diseases; American Academy of Pediatrics Bronchiolitis Guidelines Committee","year":"2014","unstructured":"American Academy of Pediatrics Committee on Infectious Diseases; American Academy of Pediatrics Bronchiolitis Guidelines Committee, Updated guidance for palivizumab prophylaxis among infants and young children at increased risk of hospitalization for respiratory syncytial virus infection. Pediatrics 134, e820\u2013e638 (2014).","journal-title":"Pediatrics"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiv284"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.4161\/mabs.23281"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1402458111"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1600996113"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1108360108"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(06)68546-2"}],"container-title":["Science Translational Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/scitranslmed.aai8711","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,16]],"date-time":"2024-01-16T13:00:36Z","timestamp":1705410036000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/scitranslmed.aai8711"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,4,5]]},"references-count":36,"journal-issue":{"issue":"384","published-print":{"date-parts":[[2017,4,5]]}},"alternative-id":["10.1126\/scitranslmed.aai8711"],"URL":"https:\/\/doi.org\/10.1126\/scitranslmed.aai8711","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.727484285.793559619","asserted-by":"object"}]},"ISSN":["1946-6234","1946-6242"],"issn-type":[{"value":"1946-6234","type":"print"},{"value":"1946-6242","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,4,5]]},"article-number":"eaai8711"}}