{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T16:57:35Z","timestamp":1790787455346,"version":"4.1.0"},"reference-count":59,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"402","funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["award298368"],"award-info":[{"award-number":["award298368"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["572516, 1057762 and 1101318"],"award-info":[{"award-number":["572516, 1057762 and 1101318"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sci. Transl. Med."],"published-print":{"date-parts":[[2017,8,9]]},"abstract":"<jats:p>A small-molecule tyrosine kinase inhibitor protects the bone marrow from chemotherapy.<\/jats:p>","DOI":"10.1126\/scitranslmed.aam8060","type":"journal-article","created":{"date-parts":[[2017,8,9]],"date-time":"2017-08-09T18:40:23Z","timestamp":1502304023000},"source":"Crossref","is-referenced-by-count":46,"title":["Preventing chemotherapy-induced myelosuppression by repurposing the FLT3 inhibitor quizartinib"],"prefix":"10.1126","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9468-8752","authenticated-orcid":false,"given":"Samuel J.","family":"Taylor","sequence":"first","affiliation":[{"name":"School of Pathology and Laboratory Medicine, University of Western Australia, Crawley, Western Australia 6009, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johanna M.","family":"Duyvestyn","sequence":"additional","affiliation":[{"name":"School of Pathology and Laboratory Medicine, University of Western Australia, Crawley, Western Australia 6009, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3087-9426","authenticated-orcid":false,"given":"Samantha A.","family":"Dagger","sequence":"additional","affiliation":[{"name":"School of Pathology and Laboratory Medicine, University of Western Australia, Crawley, Western Australia 6009, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emma J.","family":"Dishington","sequence":"additional","affiliation":[{"name":"School of Pathology and Laboratory Medicine, University of Western Australia, Crawley, Western Australia 6009, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine A.","family":"Rinaldi","sequence":"additional","affiliation":[{"name":"School of Pathology and Laboratory Medicine, University of Western Australia, Crawley, Western Australia 6009, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3586-4813","authenticated-orcid":false,"given":"Oliver M.","family":"Dovey","sequence":"additional","affiliation":[{"name":"Department of Haematology, Cambridge University Hospitals NHS Trust, Cambridge CB2 0QQ, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4337-8022","authenticated-orcid":false,"given":"George S.","family":"Vassiliou","sequence":"additional","affiliation":[{"name":"Department of Haematology, Cambridge University Hospitals NHS Trust, Cambridge CB2 0QQ, UK."},{"name":"Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2788-9893","authenticated-orcid":false,"given":"Carolyn S.","family":"Grove","sequence":"additional","affiliation":[{"name":"School of Pathology and Laboratory Medicine, University of Western Australia, Crawley, Western Australia 6009, Australia."},{"name":"PathWest Department of Haematology, Queen Elizabeth II Medical Centre, Nedlands, Western Australia 6009, Australia."},{"name":"Department of Haematology, Sir Charles Gairdner Hospital, Nedlands, Western Australia 6009, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7783-4423","authenticated-orcid":false,"given":"Wallace Y.","family":"Langdon","sequence":"additional","affiliation":[{"name":"School of Pathology and Laboratory Medicine, University of Western Australia, Crawley, Western Australia 6009, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.11882"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/91.19.1616"},{"key":"e_1_3_2_4_2","first-page":"282","article-title":"Managing thrombocytopenia associated with cancer chemotherapy","volume":"29","author":"Kuter D. J.","year":"2015","unstructured":"D. J. Kuter, Managing thrombocytopenia associated with cancer chemotherapy. Oncology 29, 282\u2013294 (2015).","journal-title":"Oncology"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1177\/0897190014546108"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19931115)72:10<2950::AID-CNCR2820721015>3.0.CO;2-B"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.2147\/TCRM.S80732"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199107183250305"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.exphem.2015.02.004"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature13824"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2010.09.008"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-06-436675"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.exphem.2014.11.009"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1096\/fj.07-9574LSF"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2184.1992.tb01435.x"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20030323"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms18051037"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2008.10.048"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V122.21.494.494"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2013.48.8783"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-05-222034"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2013-10-529313"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-10-2616"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.exphem.2016.02.008"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V96.3.925"},{"key":"e_1_3_2_26_2","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/S0022-3565(24)38879-2","article-title":"Abl protein-tyrosine kinase inhibitor STI571 inhibits in vitro signal transduction mediated by c-kit and platelet-derived growth factor receptors","volume":"295","author":"Buchdunger E.","year":"2000","unstructured":"E. Buchdunger, C. L. Cioffi, N. Law, D. Stover, S. Ohno-Jones, B. J. Druker, N. B. Lydon, Abl protein-tyrosine kinase inhibitor STI571 inhibits in vitro signal transduction mediated by c-kit and platelet-derived growth factor receptors. J. Pharmacol. Exp. Ther. 295, 139\u2013145 (2000).","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-10-3967"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2005.04.034"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2009.21.8487"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-12-0625"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2013-07-513044"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2013-10-533711"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2007.08.031"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2016.146159"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature11016"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-06-289207"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V100.3.854"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1128\/microbiolspec.MCHD-0005-2015"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01211410"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng.796"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2013.77"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2013.114"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.03445"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-10-464677"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-04-280750"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.1158\/1535-7163.MCT-15-0775"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aal3986"},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.critrevonc.2009.01.003"},{"key":"e_1_3_2_49_2","doi-asserted-by":"publisher","DOI":"10.1517\/14656566.2011.541155"},{"key":"e_1_3_2_50_2","first-page":"1","article-title":"An open-label, single-dose, phase I study of the absorption, metabolism, and excretion of quizartinib, a highly selective and potent FLT3 tyrosine kinase inhibitor, in healthy male subjects, for the treatment of acute myeloid leukemia","author":"Sanga M.","year":"2016","unstructured":"M. Sanga, J. James, J. Marini, G. Gammon, C. Hale, J. Li, An open-label, single-dose, phase I study of the absorption, metabolism, and excretion of quizartinib, a highly selective and potent FLT3 tyrosine kinase inhibitor, in healthy male subjects, for the treatment of acute myeloid leukemia. Xenobiotica, 1\u201343 (2016).","journal-title":"Xenobiotica"},{"key":"e_1_3_2_51_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1210754"},{"key":"e_1_3_2_52_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni.1889"},{"key":"e_1_3_2_53_2","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2014.117028"},{"key":"e_1_3_2_54_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1320661111"},{"key":"e_1_3_2_55_2","unstructured":"A. Galanis thesis Johns Hopkins Baltimore Maryland (2014)."},{"key":"e_1_3_2_56_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-01-0388"},{"key":"e_1_3_2_57_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0071266"},{"key":"e_1_3_2_58_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00280-008-0838-z"},{"key":"e_1_3_2_59_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2015.10.012"},{"key":"e_1_3_2_60_2","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdv209"}],"container-title":["Science Translational Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1126\/scitranslmed.aam8060","content-type":"unspecified","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/scitranslmed.aam8060","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,24]],"date-time":"2025-06-24T21:24:30Z","timestamp":1750800270000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/scitranslmed.aam8060"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8,9]]},"references-count":59,"journal-issue":{"issue":"402","published-print":{"date-parts":[[2017,8,9]]}},"alternative-id":["10.1126\/scitranslmed.aam8060"],"URL":"https:\/\/doi.org\/10.1126\/scitranslmed.aam8060","relation":{},"ISSN":["1946-6234","1946-6242"],"issn-type":[{"value":"1946-6234","type":"print"},{"value":"1946-6242","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,8,9]]},"article-number":"eaam8060"}}