{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T06:27:52Z","timestamp":1792650472384,"version":"4.5.0"},"reference-count":54,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"427","funder":[{"DOI":"10.13039\/100000005","name":"U.S. Department of Defense","doi-asserted-by":"publisher","award":["award351776"],"award-info":[{"award-number":["award351776"]}],"id":[{"id":"10.13039\/100000005","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000005","name":"U.S. Department of Defense","doi-asserted-by":"publisher","award":["W81XWH-10-1-0864"],"award-info":[{"award-number":["W81XWH-10-1-0864"]}],"id":[{"id":"10.13039\/100000005","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000098","name":"NIH Clinical Center","doi-asserted-by":"publisher","award":["award312608"],"award-info":[{"award-number":["award312608"]}],"id":[{"id":"10.13039\/100000098","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000098","name":"NIH Clinical Center","doi-asserted-by":"publisher","award":["CORT:5 p50 AR055533-05"],"award-info":[{"award-number":["CORT:5 p50 AR055533-05"]}],"id":[{"id":"10.13039\/100000098","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000005","name":"Department of Defense","doi-asserted-by":"crossref","award":["award312607"],"award-info":[{"award-number":["award312607"]}],"id":[{"id":"10.13039\/100000005","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000005","name":"Department of Defense","doi-asserted-by":"crossref","award":["W81XWH-11-1-0583"],"award-info":[{"award-number":["W81XWH-11-1-0583"]}],"id":[{"id":"10.13039\/100000005","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sci. Transl. Med."],"published-print":{"date-parts":[[2018,2,7]]},"abstract":"<jats:p>Inhibiting mitochondrial oxidant production after surgical fixation of an intra-articular fracture prevents osteoarthritis in a porcine model.<\/jats:p>","DOI":"10.1126\/scitranslmed.aan5372","type":"journal-article","created":{"date-parts":[[2018,2,8]],"date-time":"2018-02-08T05:06:48Z","timestamp":1518066408000},"source":"Crossref","is-referenced-by-count":97,"title":["Targeting mitochondrial responses to intra-articular fracture to prevent posttraumatic osteoarthritis"],"prefix":"10.1126","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5116-801X","authenticated-orcid":false,"given":"Mitchell C.","family":"Coleman","sequence":"first","affiliation":[{"name":"University of Iowa, Iowa City, IA 52242, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7197-5978","authenticated-orcid":false,"given":"Jessica E.","family":"Goetz","sequence":"additional","affiliation":[{"name":"University of Iowa, Iowa City, IA 52242, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7206-8627","authenticated-orcid":false,"given":"Marc J.","family":"Brouillette","sequence":"additional","affiliation":[{"name":"University of Iowa, Iowa City, IA 52242, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0383-3756","authenticated-orcid":false,"given":"Dongrim","family":"Seol","sequence":"additional","affiliation":[{"name":"University of Iowa, Iowa City, IA 52242, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael C.","family":"Willey","sequence":"additional","affiliation":[{"name":"University of Iowa, Iowa City, IA 52242, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7830-597X","authenticated-orcid":false,"given":"Emily B.","family":"Petersen","sequence":"additional","affiliation":[{"name":"University of Iowa, Iowa City, IA 52242, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hope D.","family":"Anderson","sequence":"additional","affiliation":[{"name":"Wellesley College, Boston, MA 02481, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathan R.","family":"Hendrickson","sequence":"additional","affiliation":[{"name":"University of Iowa, Iowa City, IA 52242, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3306-7706","authenticated-orcid":false,"given":"Jocelyn","family":"Compton","sequence":"additional","affiliation":[{"name":"University of Iowa, Iowa City, IA 52242, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Behnoush","family":"Khorsand","sequence":"additional","affiliation":[{"name":"University of Iowa, Iowa City, IA 52242, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4744-8158","authenticated-orcid":false,"given":"Angie S.","family":"Morris","sequence":"additional","affiliation":[{"name":"University of Iowa, Iowa City, IA 52242, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1923-6633","authenticated-orcid":false,"given":"Aliasger K.","family":"Salem","sequence":"additional","affiliation":[{"name":"University of Iowa, Iowa City, IA 52242, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3275-9508","authenticated-orcid":false,"given":"Douglas C.","family":"Fredericks","sequence":"additional","affiliation":[{"name":"University of Iowa, Iowa City, IA 52242, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6354-7685","authenticated-orcid":false,"given":"Todd O.","family":"McKinley","sequence":"additional","affiliation":[{"name":"Indiana University Health Methodist Hospital Orthopaedic Trauma Service, Indianapolis, IN 46202, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5085-0108","authenticated-orcid":false,"given":"James A.","family":"Martin","sequence":"additional","affiliation":[{"name":"University of Iowa, Iowa City, IA 52242, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.bot.0000246468.80635.ef"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.5435\/JAAOS-20-08-S64"},{"key":"e_1_3_2_4_2","unstructured":"A. Praemer S. Furner R. D. Furner The Burden of Musculoskeletal Diseases in the United States: Prevalence Societal and Economic Cost (AAOS 1999)."},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/BOT.0b013e3181ed298d"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-200207000-00026"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-199611000-00002"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005131-199509040-00001"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-200302000-00016"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/jor.21359"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/srep11722"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.39460"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.10686"},{"key":"e_1_3_2_14_2","first-page":"133","article-title":"The effect of mechanical stress on cartilage energy metabolism","volume":"39","author":"Lee R. B.","year":"2002","unstructured":"R. B. Lee, R. J. Wilkins, S. Razaq, J. P. Urban, The effect of mechanical stress on cartilage energy metabolism. Biorheology 39, 133\u2013143 (2002).","journal-title":"Biorheology"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/jor.21091"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/jor.22223"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10237-013-0518-8"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1567-7249(01)00037-X"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.39025"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.37782"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-8703(88)90475-9"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature13909"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.H.00545"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1128\/jb.92.5.1404-1414.1966"},{"key":"e_1_3_2_25_2","first-page":"590","article-title":"Time-dependent loss of mitochondrial function precedes progressive histologic cartilage degeneration in a rabbit meniscal destabilization model","volume":"9","author":"Goetz J. E.","year":"2016","unstructured":"J. E. Goetz, M. C. Coleman, D. C. Fredericks, E. Petersen, J. A. Martin, T. O. McKinley, Y. Tochigi, Time-dependent loss of mitochondrial function precedes progressive histologic cartilage degeneration in a rabbit meniscal destabilization model. J. Orthop. Res. 9, 590\u2013599 (2016).","journal-title":"J. Orthop. Res."},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2015.05.022"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1002\/jor.23359"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(200007)43:7<1560::AID-ANR21>3.0.CO;2-S"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780130606"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-198668020-00010"},{"key":"e_1_3_2_31_2","first-page":"304","article-title":"Basic cell metabolism of articular cartilage. Manometric studies","volume":"50","author":"Otte P.","year":"1991","unstructured":"P. Otte, Basic cell metabolism of articular cartilage. Manometric studies. Z. Rheumatol. 50, 304\u2013312 (1991).","journal-title":"Z. Rheumatol."},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1042\/bj2650911"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780330913"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2015.02.023"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1177\/1947603513487457"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.89B10.18907"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0736-0266(01)00006-7"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-197759080-00012"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aad8335"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.39049"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kem116"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1080\/10715760000300971"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2013.12.025"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1002\/jor.23389"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1002\/jor.20779"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2005.07.014"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-197153030-00009"},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.1177\/146642409111100506"},{"key":"e_1_3_2_49_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00011-017-1044-4"},{"key":"e_1_3_2_50_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2012.01.003"},{"key":"e_1_3_2_51_2","doi-asserted-by":"publisher","DOI":"10.1006\/bmmb.1994.1004"},{"key":"e_1_3_2_52_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.theriogenology.2005.06.020"},{"key":"e_1_3_2_53_2","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.a.32377"},{"key":"e_1_3_2_54_2","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.b.32981"},{"key":"e_1_3_2_55_2","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(80)90139-6"}],"container-title":["Science Translational Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1126\/scitranslmed.aan5372","content-type":"unspecified","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/scitranslmed.aan5372","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,16]],"date-time":"2024-01-16T12:56:26Z","timestamp":1705409786000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/scitranslmed.aan5372"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,2,7]]},"references-count":54,"journal-issue":{"issue":"427","published-print":{"date-parts":[[2018,2,7]]}},"alternative-id":["10.1126\/scitranslmed.aan5372"],"URL":"https:\/\/doi.org\/10.1126\/scitranslmed.aan5372","relation":{},"ISSN":["1946-6234","1946-6242"],"issn-type":[{"value":"1946-6234","type":"print"},{"value":"1946-6242","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,2,7]]},"article-number":"eaan5372"}}