{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T00:50:18Z","timestamp":1793839818915,"version":"4.6.1"},"reference-count":42,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"414","funder":[{"DOI":"10.13039\/100000738","name":"U.S. Department of Veterans Affairs","doi-asserted-by":"publisher","award":["award341899"],"award-info":[{"award-number":["award341899"]}],"id":[{"id":"10.13039\/100000738","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000738","name":"U.S. Department of Veterans Affairs","doi-asserted-by":"publisher","award":["2I01BX000338-05"],"award-info":[{"award-number":["2I01BX000338-05"]}],"id":[{"id":"10.13039\/100000738","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sci. Transl. Med."],"published-print":{"date-parts":[[2017,11]]},"abstract":"<jats:p>BLU-285 is a selective and potent mutant KIT and PDGFRA inhibitor active in both preclinical and clinical settings.<\/jats:p>","DOI":"10.1126\/scitranslmed.aao1690","type":"journal-article","created":{"date-parts":[[2017,11,1]],"date-time":"2017-11-01T16:03:59Z","timestamp":1509552239000},"source":"Crossref","is-referenced-by-count":194,"title":["A precision therapy against cancers driven by\n                    <i>KIT\/PDGFRA<\/i>\n                    mutations"],"prefix":"10.1126","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3589-1857","authenticated-orcid":false,"given":"Erica K.","family":"Evans","sequence":"first","affiliation":[{"name":"Blueprint Medicines, Cambridge, MA 02139, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra K.","family":"Gardino","sequence":"additional","affiliation":[{"name":"Blueprint Medicines, Cambridge, MA 02139, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7739-2343","authenticated-orcid":false,"given":"Joseph L.","family":"Kim","sequence":"additional","affiliation":[{"name":"Blueprint Medicines, Cambridge, MA 02139, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0530-9288","authenticated-orcid":false,"given":"Brian L.","family":"Hodous","sequence":"additional","affiliation":[{"name":"Blueprint Medicines, Cambridge, MA 02139, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam","family":"Shutes","sequence":"additional","affiliation":[{"name":"Blueprint Medicines, Cambridge, MA 02139, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4425-7871","authenticated-orcid":false,"given":"Alison","family":"Davis","sequence":"additional","affiliation":[{"name":"Blueprint Medicines, Cambridge, MA 02139, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4422-9766","authenticated-orcid":false,"given":"Xing Julia","family":"Zhu","sequence":"additional","affiliation":[{"name":"Blueprint Medicines, Cambridge, MA 02139, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1501-4985","authenticated-orcid":false,"given":"Oleg","family":"Schmidt-Kittler","sequence":"additional","affiliation":[{"name":"Blueprint Medicines, Cambridge, MA 02139, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Doug","family":"Wilson","sequence":"additional","affiliation":[{"name":"Blueprint Medicines, Cambridge, MA 02139, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin","family":"Wilson","sequence":"additional","affiliation":[{"name":"Blueprint Medicines, Cambridge, MA 02139, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucian","family":"DiPietro","sequence":"additional","affiliation":[{"name":"Blueprint Medicines, Cambridge, MA 02139, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yulian","family":"Zhang","sequence":"additional","affiliation":[{"name":"Blueprint Medicines, Cambridge, MA 02139, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3514-4189","authenticated-orcid":false,"given":"Natasja","family":"Brooijmans","sequence":"additional","affiliation":[{"name":"Blueprint Medicines, Cambridge, MA 02139, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4715-638X","authenticated-orcid":false,"given":"Timothy P.","family":"LaBranche","sequence":"additional","affiliation":[{"name":"Blueprint Medicines, Cambridge, MA 02139, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agnieszka","family":"Wozniak","sequence":"additional","affiliation":[{"name":"Laboratory of Experimental Oncology, Department of Oncology, KU Leuven, Belgium 3000."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yemarshet K.","family":"Gebreyohannes","sequence":"additional","affiliation":[{"name":"Laboratory of Experimental Oncology, Department of Oncology, KU Leuven, Belgium 3000."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5980-030X","authenticated-orcid":false,"given":"Patrick","family":"Sch\u00f6ffski","sequence":"additional","affiliation":[{"name":"Laboratory of Experimental Oncology, Department of Oncology, KU Leuven, Belgium 3000."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3790-0478","authenticated-orcid":false,"given":"Michael C.","family":"Heinrich","sequence":"additional","affiliation":[{"name":"VA Health Care System and Knight Cancer Institute, Oregon Health and Science University, Portland, OR 97239, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel J.","family":"DeAngelo","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"Miller","sequence":"additional","affiliation":[{"name":"Blueprint Medicines, Cambridge, MA 02139, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beni","family":"Wolf","sequence":"additional","affiliation":[{"name":"Blueprint Medicines, Cambridge, MA 02139, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4028-1866","authenticated-orcid":false,"given":"Nancy","family":"Kohl","sequence":"additional","affiliation":[{"name":"Blueprint Medicines, Cambridge, MA 02139, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2620-6897","authenticated-orcid":false,"given":"Timothy","family":"Guzi","sequence":"additional","affiliation":[{"name":"Blueprint Medicines, Cambridge, MA 02139, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6252-8095","authenticated-orcid":false,"given":"Nicholas","family":"Lydon","sequence":"additional","affiliation":[{"name":"Blueprint Medicines, Cambridge, MA 02139, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6702-630X","authenticated-orcid":false,"given":"Andy","family":"Boral","sequence":"additional","affiliation":[{"name":"Blueprint Medicines, Cambridge, MA 02139, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4498-7228","authenticated-orcid":false,"given":"Christoph","family":"Lengauer","sequence":"additional","affiliation":[{"name":"Blueprint Medicines, Cambridge, MA 02139, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(11)70184-X"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1006448"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1406766"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature09454"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa022457"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa020461"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00046.2011"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-04-2245"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.14694\/EdBook_AM.2012.32.66"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/path.2798"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2007.13.4452"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2007.15.7461"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/path.2382"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1079666"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(03)01046-1"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-11-3025"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2003.04.190"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.4143\/crt.2015.015"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmoldx.2010.10.004"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-04-015545"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0145-2126(02)00303-X"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1513098"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrc2559"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M403319200"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.C300186200"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0812413106"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrc3143"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1517\/14740338.2016.1152258"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-12-0625"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2567.2003.01559.x"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.exphem.2005.11.015"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.thj.6200168"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-05-2050"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-08-0366"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1186\/2045-3329-4-10"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200104053441404"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2017.35.15_suppl.11011"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V128.22.477.477"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1159\/000453057"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.1990"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/0145-2126(88)90050-1"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-14-1823"}],"container-title":["Science Translational Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1126\/scitranslmed.aao1690","content-type":"unspecified","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/scitranslmed.aao1690","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,16]],"date-time":"2024-01-16T13:22:48Z","timestamp":1705411368000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/scitranslmed.aao1690"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,11]]},"references-count":42,"journal-issue":{"issue":"414","published-print":{"date-parts":[[2017,11]]}},"alternative-id":["10.1126\/scitranslmed.aao1690"],"URL":"https:\/\/doi.org\/10.1126\/scitranslmed.aao1690","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.732068072.793552148","asserted-by":"object"}]},"ISSN":["1946-6234","1946-6242"],"issn-type":[{"value":"1946-6234","type":"print"},{"value":"1946-6242","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,11]]},"article-number":"eaao1690"}}