{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T13:06:12Z","timestamp":1793106372477,"version":"4.5.0"},"reference-count":43,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"455","funder":[{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["HL077783"],"award-info":[{"award-number":["HL077783"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["HL110950"],"award-info":[{"award-number":["HL110950"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["HL114439"],"award-info":[{"award-number":["HL114439"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["HL126596"],"award-info":[{"award-number":["HL126596"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["HL122426"],"award-info":[{"award-number":["HL122426"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004440","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["209458\/Z\/17\/Z"],"award-info":[{"award-number":["209458\/Z\/17\/Z"]}],"id":[{"id":"10.13039\/100004440","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000362","name":"Asthma UK","doi-asserted-by":"publisher","award":["AUK-IG-2014-286"],"award-info":[{"award-number":["AUK-IG-2014-286"]}],"id":[{"id":"10.13039\/501100000362","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Veterans Administration","award":["1I01BX001756"],"award-info":[{"award-number":["1I01BX001756"]}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["HL102371"],"award-info":[{"award-number":["HL102371"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004431","name":"European Commission Directorate-General for Research and Innovation","doi-asserted-by":"publisher","award":["FP7-PEOPLE-2013-IEF No627374"],"award-info":[{"award-number":["FP7-PEOPLE-2013-IEF No627374"]}],"id":[{"id":"10.13039\/100004431","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004440","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["107059\/Z\/15\/Z"],"award-info":[{"award-number":["107059\/Z\/15\/Z"]}],"id":[{"id":"10.13039\/100004440","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["HL136211"],"award-info":[{"award-number":["HL136211"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sci. Transl. Med."],"published-print":{"date-parts":[[2018,8,22]]},"abstract":"<jats:p>The matrikine PGP is a mediator of pathological epithelial remodeling in asthma.<\/jats:p>","DOI":"10.1126\/scitranslmed.aaq0693","type":"journal-article","created":{"date-parts":[[2018,8,22]],"date-time":"2018-08-22T18:06:26Z","timestamp":1534961186000},"source":"Crossref","is-referenced-by-count":45,"title":["An extracellular matrix fragment drives epithelial remodeling and airway hyperresponsiveness"],"prefix":"10.1126","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0967-9190","authenticated-orcid":true,"given":"Dhiren F.","family":"Patel","sequence":"first","affiliation":[{"name":"Inflammation Repair and Development, National Heart and Lung Institute, Imperial College London, London SW7 2AZ, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teresa","family":"Peir\u00f3","sequence":"additional","affiliation":[{"name":"Inflammation Repair and Development, National Heart and Lung Institute, Imperial College London, London SW7 2AZ, UK."},{"name":"Departamento de Ciencias Biom\u00e9dicas, Universidad Cardenal Herrera\u2013CEU, CEU Universities, Valencia 46115, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amelia","family":"Shoemark","sequence":"additional","affiliation":[{"name":"Royal Brompton and Harefield National Health Service (NHS) Trust, London SW3 6NP, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samia","family":"Akthar","sequence":"additional","affiliation":[{"name":"Inflammation Repair and Development, National Heart and Lung Institute, Imperial College London, London SW7 2AZ, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simone A.","family":"Walker","sequence":"additional","affiliation":[{"name":"Inflammation Repair and Development, National Heart and Lung Institute, Imperial College London, London SW7 2AZ, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9472-850X","authenticated-orcid":true,"given":"Aleksander M.","family":"Grabiec","sequence":"additional","affiliation":[{"name":"Manchester Collaborative Centre for Inflammation Research, University of Manchester, Manchester M13 9NT, UK."},{"name":"Department of Microbiology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Krak\u00f3w 30-387, Poland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia L.","family":"Jackson","sequence":"additional","affiliation":[{"name":"Division of Pulmonary, Allergy and Critical Care Medicine, Program in Protease and Matrix Biology, Gregory Fleming James Cystic Fibrosis Centre and Lung Health Center, University of Alabama at Birmingham, Birmingham, AL 35294, USA."},{"name":"Birmingham VA Medical Center, Birmingham, AL 35233, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tracy","family":"Hussell","sequence":"additional","affiliation":[{"name":"Manchester Collaborative Centre for Inflammation Research, University of Manchester, Manchester M13 9NT, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amit","family":"Gaggar","sequence":"additional","affiliation":[{"name":"Division of Pulmonary, Allergy and Critical Care Medicine, Program in Protease and Matrix Biology, Gregory Fleming James Cystic Fibrosis Centre and Lung Health Center, University of Alabama at Birmingham, Birmingham, AL 35294, USA."},{"name":"Birmingham VA Medical Center, Birmingham, AL 35233, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Xu","sequence":"additional","affiliation":[{"name":"Division of Pulmonary, Allergy and Critical Care Medicine, Program in Protease and Matrix Biology, Gregory Fleming James Cystic Fibrosis Centre and Lung Health Center, University of Alabama at Birmingham, Birmingham, AL 35294, USA."},{"name":"Birmingham VA Medical Center, Birmingham, AL 35233, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6072-6274","authenticated-orcid":true,"given":"Jennifer L.","family":"Trevor","sequence":"additional","affiliation":[{"name":"Division of Pulmonary, Allergy and Critical Care Medicine, Program in Protease and Matrix Biology, Gregory Fleming James Cystic Fibrosis Centre and Lung Health Center, University of Alabama at Birmingham, Birmingham, AL 35294, USA."},{"name":"Birmingham VA Medical Center, Birmingham, AL 35233, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jindong","family":"Li","sequence":"additional","affiliation":[{"name":"Division of Pulmonary, Allergy and Critical Care Medicine, Program in Protease and Matrix Biology, Gregory Fleming James Cystic Fibrosis Centre and Lung Health Center, University of Alabama at Birmingham, Birmingham, AL 35294, USA."},{"name":"Birmingham VA Medical Center, Birmingham, AL 35233, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chad","family":"Steele","sequence":"additional","affiliation":[{"name":"Division of Pulmonary, Allergy and Critical Care Medicine, Program in Protease and Matrix Biology, Gregory Fleming James Cystic Fibrosis Centre and Lung Health Center, University of Alabama at Birmingham, Birmingham, AL 35294, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7325-9545","authenticated-orcid":true,"given":"Gael","family":"Tavernier","sequence":"additional","affiliation":[{"name":"Division of Infection, Immunity and Respiratory Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Manchester M13 9NT, UK."},{"name":"Manchester University NHS Foundation Trust, Manchester M23 9LT, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5303-8123","authenticated-orcid":true,"given":"J. Edwin","family":"Blalock","sequence":"additional","affiliation":[{"name":"Division of Pulmonary, Allergy and Critical Care Medicine, Program in Protease and Matrix Biology, Gregory Fleming James Cystic Fibrosis Centre and Lung Health Center, University of Alabama at Birmingham, Birmingham, AL 35294, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2249-960X","authenticated-orcid":true,"given":"Robert M.","family":"Niven","sequence":"additional","affiliation":[{"name":"Division of Infection, Immunity and Respiratory Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Manchester M13 9NT, UK."},{"name":"Manchester University NHS Foundation Trust, Manchester M23 9LT, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa G.","family":"Gregory","sequence":"additional","affiliation":[{"name":"Inflammation Repair and Development, National Heart and Lung Institute, Imperial College London, London SW7 2AZ, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Simpson","sequence":"additional","affiliation":[{"name":"Division of Infection, Immunity and Respiratory Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Manchester M13 9NT, UK."},{"name":"Manchester University NHS Foundation Trust, Manchester M23 9LT, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8977-6726","authenticated-orcid":true,"given":"Clare M.","family":"Lloyd","sequence":"additional","affiliation":[{"name":"Inflammation Repair and Development, National Heart and Lung Institute, Imperial College London, London SW7 2AZ, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9160-7929","authenticated-orcid":true,"given":"Robert J.","family":"Snelgrove","sequence":"additional","affiliation":[{"name":"Inflammation Repair and Development, National Heart and Lung Institute, Imperial College London, London SW7 2AZ, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.01196-2014"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.prostaglandins.2007.01.006"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0952-3278(03)00073-5"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-394300-2.00002-8"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1517\/14728222.2013.843671"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.2332\/allergolint.08-RAI-0019"},{"key":"e_1_3_2_8_2","first-page":"1173","article-title":"Modulation of inflammatory disease by inhibitors of leukotriene A4 hydrolase","volume":"10","author":"Fourie A. M.","year":"2009","unstructured":"A. M. Fourie, Modulation of inflammatory disease by inhibitors of leukotriene A4 hydrolase. Curr. Opin. Investig. Drugs 10, 1173\u20131182 (2009).","journal-title":"Curr. Opin. Investig. Drugs"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pupt.2014.06.003"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI83147"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.180.8.5662"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1190594"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm1361"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl-2011-200234"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms9423"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201401-0145OC"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0802457"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200905-0725OC"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2011.06.006"},{"key":"e_1_3_2_20_2","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1183\/09031936.93.03030329","article-title":"The role of increased airway microvascular permeability and plasma exudation in asthma","volume":"3","author":"Chung K. F.","year":"1990","unstructured":"K. F. Chung, D. F. Rogers, P. J. Barnes, T. W. Evans, The role of increased airway microvascular permeability and plasma exudation in asthma. Eur. Respir. J. 3, 329\u2013337 (1990).","journal-title":"Eur. Respir. J."},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.106.115436"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200807-1158OC"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.156.3.9610046"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(95)70128-1"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2013.10.011"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1096\/fj.07-096230"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.1500175"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1038\/srep43057"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2010-0455OC"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.176.5.3157"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.175.7.4217"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI118426"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.121.5_suppl.209S"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200607-1062OC"},{"key":"e_1_3_2_35_2","first-page":"2402","article-title":"Cigarette smoke enhances chemotaxis via acetylation of proline-glycine-proline","volume":"4","author":"Hardison M. T.","year":"2012","unstructured":"M. T. Hardison, M. D. Brown, R. J. Snelgrove, J. E. Blalock, P. Jackson, Cigarette smoke enhances chemotaxis via acetylation of proline-glycine-proline. Front. Biosci. (Elite Ed). 4, 2402\u20132409 (2012).","journal-title":"Front. Biosci. (Elite Ed)."},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.273.26.16058"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI119176"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1038\/srep44449"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1186\/1465-9921-10-38"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.96.09061174"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1136\/thx.47.1.25"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201503-0543OC"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00202013"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2016.07.033"}],"container-title":["Science Translational Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1126\/scitranslmed.aaq0693","content-type":"unspecified","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/scitranslmed.aaq0693","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,16]],"date-time":"2024-01-16T18:44:53Z","timestamp":1705430693000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/scitranslmed.aaq0693"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,8,22]]},"references-count":43,"journal-issue":{"issue":"455","published-print":{"date-parts":[[2018,8,22]]}},"alternative-id":["10.1126\/scitranslmed.aaq0693"],"URL":"https:\/\/doi.org\/10.1126\/scitranslmed.aaq0693","relation":{},"ISSN":["1946-6234","1946-6242"],"issn-type":[{"value":"1946-6234","type":"print"},{"value":"1946-6242","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,8,22]]},"article-number":"eaaq0693"}}