{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T11:40:17Z","timestamp":1791632417906,"version":"4.3.4"},"reference-count":38,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"440","funder":[{"name":"NIH","award":["SPORE P50 CA9368305"],"award-info":[{"award-number":["SPORE P50 CA9368305"]}]},{"name":"NIH","award":["R01CA203721-01"],"award-info":[{"award-number":["R01CA203721-01"]}]},{"name":"NIH","award":["T32 AR-07098-36"],"award-info":[{"award-number":["T32 AR-07098-36"]}]},{"name":"NIH","award":["P30 AR069625"],"award-info":[{"award-number":["P30 AR069625"]}]},{"DOI":"10.13039\/100000069","name":"NIAMS","doi-asserted-by":"crossref","award":["R01 AR063962"],"award-info":[{"award-number":["R01 AR063962"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sci. Transl. Med."],"published-print":{"date-parts":[[2018,5,9]]},"abstract":"<jats:p>The malignant T cell clone frequency in cutaneous T cell lymphoma lesions is an independent prognostic indicator for early disease progression and death.<\/jats:p>","DOI":"10.1126\/scitranslmed.aar5894","type":"journal-article","created":{"date-parts":[[2018,5,9]],"date-time":"2018-05-09T14:11:01Z","timestamp":1525875061000},"source":"Crossref","is-referenced-by-count":139,"title":["High-throughput sequencing of the T cell receptor \u03b2 gene identifies aggressive early-stage mycosis fungoides"],"prefix":"10.1126","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7828-6211","authenticated-orcid":true,"given":"Adele","family":"de Masson","sequence":"first","affiliation":[{"name":"Department of Dermatology, Brigham and Women\u2019s Hospital, and the Center for Cutaneous Oncology, Dana-Farber\/Brigham and Women\u2019s Cancer Center, Harvard Medical School, Boston, MA 02115, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9968-1517","authenticated-orcid":true,"given":"John T.","family":"O\u2019Malley","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Brigham and Women\u2019s Hospital, and the Center for Cutaneous Oncology, Dana-Farber\/Brigham and Women\u2019s Cancer Center, Harvard Medical School, Boston, MA 02115, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher P.","family":"Elco","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Brigham and Women\u2019s Hospital, and the Center for Cutaneous Oncology, Dana-Farber\/Brigham and Women\u2019s Cancer Center, Harvard Medical School, Boston, MA 02115, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah S.","family":"Garcia","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Brigham and Women\u2019s Hospital, and the Center for Cutaneous Oncology, Dana-Farber\/Brigham and Women\u2019s Cancer Center, Harvard Medical School, Boston, MA 02115, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9148-8691","authenticated-orcid":true,"given":"Sherrie J.","family":"Divito","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Brigham and Women\u2019s Hospital, and the Center for Cutaneous Oncology, Dana-Farber\/Brigham and Women\u2019s Cancer Center, Harvard Medical School, Boston, MA 02115, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7892-608X","authenticated-orcid":true,"given":"Elizabeth L.","family":"Lowry","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Brigham and Women\u2019s Hospital, and the Center for Cutaneous Oncology, Dana-Farber\/Brigham and Women\u2019s Cancer Center, Harvard Medical School, Boston, MA 02115, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marianne","family":"Tawa","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Brigham and Women\u2019s Hospital, and the Center for Cutaneous Oncology, Dana-Farber\/Brigham and Women\u2019s Cancer Center, Harvard Medical School, Boston, MA 02115, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David C.","family":"Fisher","sequence":"additional","affiliation":[{"name":"Center for Hematologic Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phillip M.","family":"Devlin","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Dana-Farber\/Brigham and Women\u2019s Cancer Center, Harvard Medical School, Boston, MA 02115, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica E.","family":"Teague","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Brigham and Women\u2019s Hospital, and the Center for Cutaneous Oncology, Dana-Farber\/Brigham and Women\u2019s Cancer Center, Harvard Medical School, Boston, MA 02115, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole R.","family":"Leboeuf","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Brigham and Women\u2019s Hospital, and the Center for Cutaneous Oncology, Dana-Farber\/Brigham and Women\u2019s Cancer Center, Harvard Medical School, Boston, MA 02115, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilan R.","family":"Kirsch","sequence":"additional","affiliation":[{"name":"Adaptive Biotechnologies, Seattle, WA 98102, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5225-7076","authenticated-orcid":true,"given":"Harlan","family":"Robins","sequence":"additional","affiliation":[{"name":"Adaptive Biotechnologies, Seattle, WA 98102, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6105-5764","authenticated-orcid":true,"given":"Rachael A.","family":"Clark","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Brigham and Women\u2019s Hospital, and the Center for Cutaneous Oncology, Dana-Farber\/Brigham and Women\u2019s Cancer Center, Harvard Medical School, Boston, MA 02115, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4229-2916","authenticated-orcid":true,"given":"Thomas S.","family":"Kupper","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Brigham and Women\u2019s Hospital, and the Center for Cutaneous Oncology, Dana-Farber\/Brigham and Women\u2019s Cancer Center, Harvard Medical School, Boston, MA 02115, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra032810"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.136.4.504"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aaa9122"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-04-217604"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2009.27.7665"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.3816\/CLML.2010.s.008"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.det.2015.05.014"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2013.098145"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2014-07-588236"},{"key":"e_1_3_2_11_2","doi-asserted-by":"crossref","first-page":"1713","DOI":"10.1182\/blood-2007-03-055749","article-title":"Revisions to the staging and classification of mycosis fungoides and Sezary syndrome: A proposal of the International Society for Cutaneous Lymphomas (ISCL) and the cutaneous lymphoma task force of the European Organization of Research and Treatment of Cancer (EORTC)","volume":"110","author":"Olsen E.","year":"2007","unstructured":"E. Olsen, E. Vonderheid, N. Pimpinelli, R. Willemze, Y. Kim, R. Knobler, H. Zackheim, M. Duvic, T. Estrach, S. Lamberg, G. Wood, R. Dummer, A. Ranki, G. Burg, P. Heald, M. Pittelkow, M.-G. Bernengo, W. Sterry, L. Laroche, F. Trautinger, S. Whittaker; ISCL\/EORTC, Revisions to the staging and classification of mycosis fungoides and Sezary syndrome: A proposal of the International Society for Cutaneous Lymphomas (ISCL) and the cutaneous lymphoma task force of the European Organization of Research and Treatment of Cancer (EORTC). Blood 110, 1713\u20131722 (2007).","journal-title":"Blood"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2013.04.018"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.14559"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-09-2879"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-14-3322"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-12-061507"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2005.08.057"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3860"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3003656"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2015-02-630335"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3007420"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jid.5701109"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-09-3502"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng.3444"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V89.1.32.32_32_40"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0258(19960229)15:4<361::AID-SIM168>3.0.CO;2-4"},{"key":"e_1_3_2_27_2","doi-asserted-by":"crossref","first-page":"2598","DOI":"10.1200\/JCO.2010.32.0630","article-title":"Clinical end points and response criteria in mycosis fungoides and S\u00e9zary syndrome: A consensus statement of the International Society for Cutaneous Lymphomas, the United States Cutaneous Lymphoma Consortium, and the Cutaneous Lymphoma Task Force of the European Organisation for Research and Treatment of Cancer","volume":"29","author":"Olsen E. A.","year":"2011","unstructured":"E. A. Olsen, S. Whittaker, Y. H. Kim, M. Duvic, H. M. Prince, S. R. Lessin, G. S. Wood, R. Willemze, M.-F. Demierre, N. Pimpinelli, M. G. Bernengo, P. L. Ortiz-Romero, M. Bagot, T. Estrach, J. Guitart, R. Knobler, J. A. Sanches, K. Iwatsuki, M. Sugaya, R. Dummer, M. Pittelkow, R. Hoppe, S. Parker, L. Geskin, L. Pinter-Brown, M. Girardi, G. Burg, A. Ranki, M. Vermeer, S. Horwitz, P. Heald, S. Rosen, L. Cerroni, B. Dreno, E. C. Vonderheid;International Society for Cutaneous Lymphomas, United States Cutaneous Lymphoma Consortium, Cutaneous Lymphoma Task Force of the European Organisation for Research and Treatment of Cancer, Clinical end points and response criteria in mycosis fungoides and S\u00e9zary syndrome: A consensus statement of the International Society for Cutaneous Lymphomas, the United States Cutaneous Lymphoma Consortium, and the Cutaneous Lymphoma Task Force of the European Organisation for Research and Treatment of Cancer. J. Clin. Oncol. 29, 2598\u20132607 (2011).","journal-title":"J. Clin. Oncol."},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng.3442"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng.3356"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature13954"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng.3370"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/0190-9622(95)90067-5"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2001.19.23.4322"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2016-02-698977"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms3680"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1101\/pdb.top115"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-60327-118-9_2"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1038\/nbt1385"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.2514"}],"container-title":["Science Translational Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1126\/scitranslmed.aar5894","content-type":"unspecified","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/scitranslmed.aar5894","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,16]],"date-time":"2024-01-16T12:52:31Z","timestamp":1705409551000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/scitranslmed.aar5894"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,5,9]]},"references-count":38,"journal-issue":{"issue":"440","published-print":{"date-parts":[[2018,5,9]]}},"alternative-id":["10.1126\/scitranslmed.aar5894"],"URL":"https:\/\/doi.org\/10.1126\/scitranslmed.aar5894","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.733198100.793573963","asserted-by":"object"}]},"ISSN":["1946-6234","1946-6242"],"issn-type":[{"value":"1946-6234","type":"print"},{"value":"1946-6242","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,5,9]]},"article-number":"eaar5894"}}