{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T18:08:36Z","timestamp":1790705316861,"version":"4.1.0"},"reference-count":68,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"535","funder":[{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","award":["MH096625"],"award-info":[{"award-number":["MH096625"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["NS105584"],"award-info":[{"award-number":["NS105584"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["NS105584"],"award-info":[{"award-number":["NS105584"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003323","name":"Agence Nationale de Recherches sur le Sida et les Hepatites Virales","doi-asserted-by":"publisher","award":["ANRS-2014AO21038"],"award-info":[{"award-number":["ANRS-2014AO21038"]}],"id":[{"id":"10.13039\/501100003323","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000025","name":"The National Institute of Mental Health","doi-asserted-by":"crossref","award":["MH096625"],"award-info":[{"award-number":["MH096625"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sci. Transl. Med."],"published-print":{"date-parts":[[2020,3,18]]},"abstract":"<jats:p>In virally suppressed HIV-infected individuals on antiretroviral drug therapy, platelets harboring HIV correlate with poor immunological recovery.<\/jats:p>","DOI":"10.1126\/scitranslmed.aat6263","type":"journal-article","created":{"date-parts":[[2020,3,18]],"date-time":"2020-03-18T23:14:29Z","timestamp":1584573269000},"source":"Crossref","is-referenced-by-count":75,"title":["Platelets from HIV-infected individuals on antiretroviral drug therapy with poor CD4\n            <sup>+<\/sup>\n            T cell recovery can harbor replication-competent HIV despite viral suppression"],"prefix":"10.1126","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5060-4334","authenticated-orcid":true,"given":"Fernando","family":"Real","sequence":"first","affiliation":[{"name":"Mucosal Entry of HIV and Mucosal Immunity, Institut Cochin, Universit\u00e9 de Paris, Paris, France."},{"name":"INSERM U1016, Paris, France."},{"name":"CNRS UMR8104, Paris, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claude","family":"Capron","sequence":"additional","affiliation":[{"name":"H\u00f4pital Ambroise Par\u00e9, Boulogne-Billancourt, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8124-1727","authenticated-orcid":true,"given":"Alexis","family":"Sennepin","sequence":"additional","affiliation":[{"name":"Mucosal Entry of HIV and Mucosal Immunity, Institut Cochin, Universit\u00e9 de Paris, Paris, France."},{"name":"INSERM U1016, Paris, France."},{"name":"CNRS UMR8104, Paris, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riccardo","family":"Arrigucci","sequence":"additional","affiliation":[{"name":"Public Health Research Institute, New Jersey Medical School, Rutgers, The State University of New Jersey, Newark, NJ, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aiwei","family":"Zhu","sequence":"additional","affiliation":[{"name":"Mucosal Entry of HIV and Mucosal Immunity, Institut Cochin, Universit\u00e9 de Paris, Paris, France."},{"name":"INSERM U1016, Paris, France."},{"name":"CNRS UMR8104, Paris, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7956-4463","authenticated-orcid":true,"given":"G\u00e9r\u00e9my","family":"Sannier","sequence":"additional","affiliation":[{"name":"Mucosal Entry of HIV and Mucosal Immunity, Institut Cochin, Universit\u00e9 de Paris, Paris, France."},{"name":"INSERM U1016, Paris, France."},{"name":"CNRS UMR8104, Paris, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1735-4732","authenticated-orcid":true,"given":"Jonathan","family":"Zheng","sequence":"additional","affiliation":[{"name":"Mucosal Entry of HIV and Mucosal Immunity, Institut Cochin, Universit\u00e9 de Paris, Paris, France."},{"name":"INSERM U1016, Paris, France."},{"name":"CNRS UMR8104, Paris, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1345-5189","authenticated-orcid":true,"given":"Lin","family":"Xu","sequence":"additional","affiliation":[{"name":"Mucosal Entry of HIV and Mucosal Immunity, Institut Cochin, Universit\u00e9 de Paris, Paris, France."},{"name":"INSERM U1016, Paris, France."},{"name":"CNRS UMR8104, Paris, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9904-7236","authenticated-orcid":true,"given":"Jean-Marc","family":"Mass\u00e9","sequence":"additional","affiliation":[{"name":"INSERM U1016, Paris, France."},{"name":"CNRS UMR8104, Paris, France."},{"name":"Electron Microscopy Platform, Institut Cochin, Universit\u00e9 de Paris, Paris, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00e9gol\u00e8ne","family":"Greffe","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, H\u00f4pital Ambroise Par\u00e9, Boulogne, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle","family":"Cazabat","sequence":"additional","affiliation":[{"name":"CHU de Toulouse, H\u00f4pital Purpan, Laboratoire de Virologie, Toulouse, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1377-9466","authenticated-orcid":true,"given":"Maribel","family":"Donoso","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Cell Biology, and Anatomy, University of Texas Medical Branch (UTMB), Galveston, TX, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2874-3581","authenticated-orcid":true,"given":"Pierre","family":"Delobel","sequence":"additional","affiliation":[{"name":"INSERM U1043, Toulouse, France."},{"name":"Universit\u00e9 Toulouse III Paul-Sabatier, Facult\u00e9 de M\u00e9decine Toulouse-Purpan, Toulouse, France."},{"name":"CHU de Toulouse, H\u00f4pital Purpan, Service des Maladies Infectieuses et Tropicales, Toulouse, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8462-3234","authenticated-orcid":true,"given":"Jacques","family":"Izopet","sequence":"additional","affiliation":[{"name":"CHU de Toulouse, H\u00f4pital Purpan, Laboratoire de Virologie, Toulouse, France."},{"name":"INSERM U1043, Toulouse, France."},{"name":"Universit\u00e9 Toulouse III Paul-Sabatier, Facult\u00e9 de M\u00e9decine Toulouse-Purpan, Toulouse, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2925-4720","authenticated-orcid":true,"given":"Eliseo","family":"Eugenin","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Cell Biology, and Anatomy, University of Texas Medical Branch (UTMB), Galveston, TX, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Laura","family":"Gennaro","sequence":"additional","affiliation":[{"name":"Public Health Research Institute, New Jersey Medical School, Rutgers, The State University of New Jersey, Newark, NJ, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4683-5041","authenticated-orcid":true,"given":"Elisabeth","family":"Rouveix","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, H\u00f4pital Ambroise Par\u00e9, Boulogne, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabeth","family":"Cramer Bord\u00e9","sequence":"additional","affiliation":[{"name":"Mucosal Entry of HIV and Mucosal Immunity, Institut Cochin, Universit\u00e9 de Paris, Paris, France."},{"name":"INSERM U1016, Paris, France."},{"name":"H\u00f4pital Ambroise Par\u00e9, Boulogne-Billancourt, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9577-7474","authenticated-orcid":true,"given":"Morgane","family":"Bomsel","sequence":"additional","affiliation":[{"name":"Mucosal Entry of HIV and Mucosal Immunity, Institut Cochin, Universit\u00e9 de Paris, Paris, France."},{"name":"INSERM U1016, Paris, France."},{"name":"CNRS UMR8104, Paris, France."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri2956"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2015.00070"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2014.00649"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1590\/S1517-838246220140553"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2006.01749.x"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12865-015-0092-1"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00136-06"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-009-0209-x"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2014-09-598029"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2001-12-0191"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V75.10.1920.1920"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.1998.38698326338.x"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.8248811"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.86.14.5595"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm.4108"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2017.079"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2016.07.015"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.00876-17"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(02)09291-7"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm.4347"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1006509"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0903107106"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2012.08.010"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199212173272503"},{"key":"e_1_3_2_26_2","doi-asserted-by":"crossref","unstructured":"J. E. Italiano Jr. J. Hartwig Production and destruction of platelets in The Non-Thrombotic Role of Platelets in Health and Disease S. W. Kerrigan Ed. (IntechOpen 2015).","DOI":"10.5772\/60678"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1111\/voxs.12144"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1097\/MOH.0b013e32833e7561"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10875-005-2816-0"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1086\/597093"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2017.01698"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41564-018-0335-z"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1080\/01913120701344343"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2008.06.002"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-04-215186"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1586\/14787210.2016.1106937"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-med-042909-093756"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.7448\/IAS.18.1.20052"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jir507"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm.4319"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.163.18.2187"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.aids.0000247588.69438.fd"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1002\/JLB.4A0919-235R"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2011.08793.x"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.21368"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-61779-307-3_12"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2164-7-115"},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2017.039"},{"key":"e_1_3_2_49_2","doi-asserted-by":"publisher","DOI":"10.1002\/sim.4780090502"},{"key":"e_1_3_2_50_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(85)91994-4"},{"key":"e_1_3_2_51_2","first-page":"9","article-title":"HTLV-III\/LAV viral antigens in lymph nodes of homosexual men with persistent generalized lymphadenopathy and AIDS","volume":"123","author":"Tenner-Racz K.","year":"1986","unstructured":"K. Tenner-Racz, P. Racz, M. Bofill, A. Schulz-Meyer, M. Dietrich, P. Kern, J. Weber, A. J. Pinching, F. Veronese-Dimarzo, M. Popovic, D. Klatzmann, J. C. Gluckman, G. Janossy, HTLV-III\/LAV viral antigens in lymph nodes of homosexual men with persistent generalized lymphadenopathy and AIDS. Am. J. Pathol. 123, 9\u201315 (1986).","journal-title":"Am. J. Pathol."},{"key":"e_1_3_2_52_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(86)80089-2"},{"key":"e_1_3_2_53_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(88)80202-8"},{"key":"e_1_3_2_54_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.73.3.2343-2349.1999"},{"key":"e_1_3_2_55_2","first-page":"Unit 26.5","article-title":"HIV-1 interactions with cells: From viral binding to cell-cell transmission","volume":"26","author":"Janas A. M.","year":"2009","unstructured":"A. M. Janas, L. Wu, HIV-1 interactions with cells: From viral binding to cell-cell transmission. Curr. Protoc. Cell Biol. Chapter 26, Unit 26.5 (2009).","journal-title":"Curr. Protoc. Cell Biol."},{"key":"e_1_3_2_56_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymeth.2009.01.002"},{"key":"e_1_3_2_57_2","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2013.219378"},{"key":"e_1_3_2_58_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2008.05.030"},{"key":"e_1_3_2_59_2","doi-asserted-by":"publisher","DOI":"10.20411\/pai.v1i1.100"},{"key":"e_1_3_2_60_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2018.04.028"},{"key":"e_1_3_2_61_2","doi-asserted-by":"publisher","DOI":"10.1002\/cpcb.64"},{"key":"e_1_3_2_62_2","doi-asserted-by":"publisher","DOI":"10.1038\/35393"},{"key":"e_1_3_2_63_2","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0000000000002295"},{"key":"e_1_3_2_64_2","doi-asserted-by":"publisher","DOI":"10.1038\/srep16944"},{"key":"e_1_3_2_65_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkh340"},{"key":"e_1_3_2_66_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btp348"},{"key":"e_1_3_2_67_2","doi-asserted-by":"publisher","DOI":"10.1080\/10635150390235520"},{"key":"e_1_3_2_68_2","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.2109"},{"key":"e_1_3_2_69_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkz239"}],"container-title":["Science Translational Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1126\/scitranslmed.aat6263","content-type":"unspecified","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/scitranslmed.aat6263","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,16]],"date-time":"2024-01-16T17:46:47Z","timestamp":1705427207000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/scitranslmed.aat6263"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3,18]]},"references-count":68,"journal-issue":{"issue":"535","published-print":{"date-parts":[[2020,3,18]]}},"alternative-id":["10.1126\/scitranslmed.aat6263"],"URL":"https:\/\/doi.org\/10.1126\/scitranslmed.aat6263","relation":{},"ISSN":["1946-6234","1946-6242"],"issn-type":[{"value":"1946-6234","type":"print"},{"value":"1946-6242","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,3,18]]},"article-number":"eaat6263"}}