{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T23:38:23Z","timestamp":1792798703677,"version":"4.5.0"},"reference-count":50,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"475","funder":[{"name":"vTv Therapeutics LLC","id":[{"id":"https:\/\/ror.org\/051vfhx38","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sci. Transl. Med."],"published-print":{"date-parts":[[2019,1,16]]},"abstract":"<jats:p>A hepatoselective glucokinase activator reduced hyperglycemia without hypoglycemia or adverse effects on lipids, liver enzymes, or blood pressure.<\/jats:p>","DOI":"10.1126\/scitranslmed.aau3441","type":"journal-article","created":{"date-parts":[[2019,1,16]],"date-time":"2019-01-16T19:24:19Z","timestamp":1547666659000},"source":"Crossref","is-referenced-by-count":64,"title":["Targeting hepatic glucokinase to treat diabetes with TTP399, a hepatoselective glucokinase activator"],"prefix":"10.1126","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6493-7837","authenticated-orcid":true,"given":"Adrian","family":"Vella","sequence":"first","affiliation":[{"name":"Division of Endocrinology and Diabetes, Department of Medicine, Mayo Clinic, Rochester, MN 55905, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer L. R.","family":"Freeman","sequence":"additional","affiliation":[{"name":"vTv Therapeutics Inc. and vTv Therapeutics LLC, High Point, NC 27265, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Imogene","family":"Dunn","sequence":"additional","affiliation":[{"name":"vTv Therapeutics Inc. and vTv Therapeutics LLC, High Point, NC 27265, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kit","family":"Keller","sequence":"additional","affiliation":[{"name":"vTv Therapeutics Inc. and vTv Therapeutics LLC, High Point, NC 27265, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John B.","family":"Buse","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolism, Department of Medicine, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"Valcarce","sequence":"additional","affiliation":[{"name":"vTv Therapeutics Inc. and vTv Therapeutics LLC, High Point, NC 27265, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/MCO.0b013e32833a558d"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ympev.2013.09.016"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0055727"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI117064"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20080595"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199801223380404"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.47.3.307"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-008-8322-9"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.50.6.1351"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1042\/bst0250113"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-1033.1990.tb19147.x"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-1033.1991.tb16217.x"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1042\/bj2940551"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1142358"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.2337\/db08-0516"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-007-0865-z"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.2337\/db07-1807"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddp357"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.2337\/db08-1277"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrd2850"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.2337\/db08-1470"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.2174\/1389557514666140722082713"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1517\/14728222.2014.965681"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1111\/dom.12586"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.2012.02184.x"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1097\/MOL.0000000000000155"},{"issue":"1","key":"e_1_3_2_28_2","first-page":"A32","article-title":"TTP399, a liver-selective glucose kinase activator (GKA), lowers glucose and does not increase lipids in subjects with type 2 diabetes mellitus (T2DM)","volume":"63","author":"Valcarce C.","year":"2016","unstructured":"C. Valcarce, I. Grimes, S. Gustavson, A. H. Burstein, A. Mjalli, TTP399, a liver-selective glucose kinase activator (GKA), lowers glucose and does not increase lipids in subjects with type 2 diabetes mellitus (T2DM). Diabetes 63 ( suppl. 1), A32 (2016).","journal-title":"Diabetes"},{"issue":"1","key":"e_1_3_2_29_2","first-page":"A299","article-title":"TTP399, a novel, liver selective glucokinase activator: Results from a 10-day pilot study in patients with type 2 diabetes mellitus (T2DM) na\u00efve to drug [abstract]","volume":"65","author":"Valcarce C.","year":"2016","unstructured":"C. Valcarce, I. Dunn, J. Freeman, TTP399, a novel, liver selective glucokinase activator: Results from a 10-day pilot study in patients with type 2 diabetes mellitus (T2DM) na\u00efve to drug [abstract]. Diabetes 65 ( suppl. 1), A299 (2016).","journal-title":"Diabetes"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1517\/13543784.17.2.145"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2011.05.009"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2011.10.113"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1517\/17460441.2013.748744"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1124\/mol.111.074401"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2013.06.015"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1111\/bph.12172"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1177\/0192623314526006"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1021\/jm900839k"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1021\/jm2014887"},{"key":"e_1_3_2_40_2","unstructured":"D. Kazierad J. Pfefferkorn A. Bergman X. Wang T. P. Rolph J. M. Rusnak The hepatoselective glucokinase activator (GKA) PF-04991532 lowers HbA1c after 12 weeks of dosing in patients with type 2 diabetes (T2DM) in 73rd American Diabetes Conference Chicago IL 21 to 25 June 2013."},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.2337\/dc11-1200"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M605186200"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M805434200"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature12724"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1111\/dom.12088"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.2337\/db16-0240"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2017-01197"},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1409638111"},{"key":"e_1_3_2_49_2","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2001.28704"},{"key":"e_1_3_2_50_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2818.2002.01054.x"},{"key":"e_1_3_2_51_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-679X(08)61797-5"}],"container-title":["Science Translational Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1126\/scitranslmed.aau3441","content-type":"unspecified","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/scitranslmed.aau3441","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,16]],"date-time":"2024-01-16T12:10:17Z","timestamp":1705407017000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/scitranslmed.aau3441"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1,16]]},"references-count":50,"journal-issue":{"issue":"475","published-print":{"date-parts":[[2019,1,16]]}},"alternative-id":["10.1126\/scitranslmed.aau3441"],"URL":"https:\/\/doi.org\/10.1126\/scitranslmed.aau3441","relation":{},"ISSN":["1946-6234","1946-6242"],"issn-type":[{"value":"1946-6234","type":"print"},{"value":"1946-6242","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,1,16]]},"article-number":"eaau3441"}}